Atrial Fibrillation
March 2021 Issue

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Atrial Fibrillation abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Atrial Fibrillation. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Atrial Fibrillation. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Atrial Fibrillation every 3 months. Thank you for your ongoing subscription to this publication.

Elliot Jacob, Ph.D.
Vice-President - Content, Inc.

1:Chronic kidney disease and cardiovascular mortality in patients with atrial fibrillation: European Society of Hypertension project - ESH A Fib.
Authors:Premužić V, Stevanović R, Radić P, Salvetti M, Lovrić-Benčić M, Jelaković A, Miličić D, Capak K, Agabiti-Rosei E, Jelaković B
Institution:Department of Nephrology, Hypertension, Dialysis and Transplantation, University Hospital Center Zagreb.
Journal:Medicine (Baltimore). 2021 Jan 15;100(2):e23975. doi: 10.1097/MD.0000000000023975.

2:Comparison of sustained rate control in atrial fibrillation with rapid ventricular rate: Metoprolol vs. Diltiazem.
Authors:Hargrove KL, Robinson EE, Lusk KA, Hughes DW, Neff LA, Fowler AL
Institution:University Health, San Antonio, TX 78229, United States; University of Texas Health San Antonio, Pharmacotherapy Education & Research Center, San Antonio, TX 78229, United States; The University of Texas at Austin, College of Pharmacy, Austin, TX 78712, United States; University of the Incarnate Word, Feik School of Pharmacy, San Antonio, TX 78209, United States. Electronic address:
Journal:Am J Emerg Med. 2021 Feb;40:15-19. doi: 10.1016/j.ajem.2020.11.073. Epub 2020 Dec 3.

3:Cryoablation or Drug Therapy for Initial Treatment of Atrial Fibrillation.
Authors:Andrade JG, Wells GA, Deyell MW, Bennett M, Essebag V, Champagne J, Roux JF, Yung D, Skanes A, Khaykin Y, Morillo C, Jolly U, Novak P, Lockwood E, Amit G, Angaran P, Sapp J, Wardell S, Lauck S, Macle L, Verma A
Institution:From Vancouver General Hospital (J.G.A., M.B.), the University of British Columbia (J.G.A., M.W.D., M.B., S.L.), and the Centre for Cardiovascular Innovation (J.G.A., M.W.D.), Vancouver, Montreal Heart Institute, Universite de Montreal (J.G.A., L.M.) and McGill University Health Centre (V.E.), Montreal, the University of Ottawa Heart Institute, Ottawa (G.A.W.), Universite Laval, Quebec, QC (J.C.), Universite de Sherbrooke, Sherbrooke, QC (J.-F.R.), Rouge Valley Centenary Hospital, Scarborough, ON (D.Y.), Western University, London, ON (A.S.), Southlake Regional Health Centre, University of Toronto, Newmarket, ON (Y.K., A.V.), Libin Cardiovascular Institute, University of Calgary, Calgary, AB (C.M.), St. Mary's General Hospital, Kitchener, ON (U.J.), Royal Jubilee Hospital, Victoria, BC (P.N.), Royal Alexandra Hospital, Edmonton, AB (E.L.), McMaster University, Hamilton, ON (G.A.), St. Michael's Hospital, University of Toronto, Toronto (P.A.), Dalhousie University, Halifax, NS (J.S.), an
Journal:N Engl J Med. 2021 Jan 28;384(4):305-315. doi: 10.1056/NEJMoa2029980. Epub 2020 Nov 16.

4:Coronary heart disease and atrial fibrillation: a vicious cycle.
Authors:Liang F, Wang Y
Institution:Department of Cardiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Journal:Am J Physiol Heart Circ Physiol. 2021 Jan 1;320(1):H1-H12. doi: 10.1152/ajpheart.00702.2020. Epub 2020 Nov 13.

5:Renal function and outcomes in atrial fibrillation patients after catheter ablation.
Authors:Kawaji T, Shizuta S, Aizawa T, Yamagami S, Takeji Y, Yoshikawa Y, Kato M, Yokomatsu T, Miki S, Ono K, Kimura T
Institution:Department of Cardiology, Ryorei Memorial Kyoto Hospital, Kyoto, Japan. Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Journal:PLoS One. 2020 Nov 9;15(11):e0241449. doi: 10.1371/journal.pone.0241449. eCollection 2020.

6:"Pill in the Pocket" Antiarrhythmic Drugs for Orally Administered Pharmacologic Cardioversion of Atrial Fibrillation.
Authors:Reiffel JA, Capucci A
Institution:Columbia University Medical Center, New York City, New York. Electronic address: Marche Polytechnic University, Ancona, Italy.
Journal:Am J Cardiol. 2021 Feb 1;140:55-61. doi: 10.1016/j.amjcard.2020.10.063. Epub 2020 Nov 2.

7:New-onset atrial fibrillation during COVID-19 infection predicts poor prognosis.
Authors:Pardo Sanz A, Salido Tahoces L, Ortega Pérez R, González Ferrer E, Sánchez Recalde Á, Zamorano Gómez JL
Institution:Ramon y Cajal hospital, Carretera de colmenar km 9,100, 28034 Madrid, Spain.
Journal:Cardiol J. 2021;28(1):34-40. doi: 10.5603/CJ.a2020.0145. Epub 2020 Nov 3.

8:Previously Undetected Obstructive Sleep Apnea in Patients With New-Onset Atrial Fibrillation.
Authors:Bazan V, Vicente I, Lozano L, Villuendas R, González M, Adeliño R, Bisbal F, Sarrias A, Abad J, Sanz-Santos J, Padilla F, Bayés-Genís A
Institution:Cardiology Department, Hospital Universitari Germans Trias i Pujol, Badalona, Spain; CIBERCV, Ciber de Enfermedades Respiratorias, Madrid, Spain. Universitat Autonoma de Barcelona. Barcelona. Spain. Electronic address:
Journal:Am J Cardiol. 2021 Jan 1;138:46-52. doi: 10.1016/j.amjcard.2020.09.058. Epub 2020 Oct 13.

9:Incidence and Predictors of 30-day Acute Cerebrovascular Accidents Post Atrial Fibrillation Catheter Ablation (From the Nationwide Readmissions Database).
Authors:Patil N, Arora S, Davis L, Akoum NW, Chung MK, Sridhar AR
Institution:Division of Cardiology, University of North Carolina, Chapel Hill, North Carolina; Division of Hospital Medicine, UNC Nash General Hospital, Rocky Mount, North Carolina. Section of Cardiac Electrophysiology, UW Heart Institute, University of Washington, Seattle, Washington. Electronic address:
Journal:Am J Cardiol. 2021 Jan 1;138:61-65. doi: 10.1016/j.amjcard.2020.10.020. Epub 2020 Oct 13.

10:Magnetic Resonance Imaging-Guided Fibrosis Ablation for the Treatment of Atrial Fibrillation: The ALICIA Trial.
Authors:Bisbal F, Benito E, Teis A, Alarcón F, Sarrias A, Caixal G, Villuendas R, Garre P, Soto N, Cozzari J, Guasch E, Juncà G, Prat-Gonzalez S, Perea RJ, Bazán V, Tolosana JM, Arbelo E, Bayés-Genís A, Mont L
Institution:Heart Institute (iCor), University Hospital Germans Trias i Pujol, Badalona, Catalonia (F.B., A.T., A.S., R.V., N.S., G.J., V.B., A.B.-G.). CIBERCV, Instituto de Salud Carlos III, Madrid (F.B., A.B.-G., L.M.).
Journal:Circ Arrhythm Electrophysiol. 2020 Nov;13(11):e008707. doi: 10.1161/CIRCEP.120.008707. Epub 2020 Oct 8.

11:Risk of Ischemic Stroke in Patients With Atrial Fibrillation After Extracranial Hemorrhage.
Authors:Zhou E, Lord A, Boehme A, Henninger N, de Havenon A, Vahidy F, Ishida K, Torres J, Mistry EA, Mac Grory B, Sheth KN, Gurol ME, Furie K, Elkind MSV, Yaghi S
Institution:NYU Grossman School of Medicine, New York, NY (E.Z.). Department of Neurology, NYU Langone Health, New York, NY (A.L., K.I., J.T., S.Y.).
Journal:Stroke. 2020 Dec;51(12):3592-3599. doi: 10.1161/STROKEAHA.120.029959. Epub 2020 Oct 8.

12:Microbleeds and Outcome in Patients With Acute Ischemic Stroke and Atrial Fibrillation Taking Anticoagulants.
Authors:Choi KH, Kim JH, Lee C, Kim JM, Kang KW, Kim JT, Choi SM, Park MS, Cho KH
Institution:Department of Neurology (K.-H. Choi, J.-M.K., K.-W.K., J.-T.K., S.-M.C., M.-S.P., K.-H. Cho), Chonnam National University Medical School and Hospital, Gwangju, Korea.
Journal:Stroke. 2020 Dec;51(12):3514-3522. doi: 10.1161/STROKEAHA.120.030300. Epub 2020 Oct 8.

13:Catheter Ablation for Atrial Fibrillation in Patients With Concurrent Heart Failure.
Authors:Arora S, Jaswaney R, Jani C, Zuzek Z, Thakkar S, Patel HP, Patel M, Patel N, Tripathi B, Lahewala S, Arora N, Josephson R, Osman MN, Hoit BD, Kowlgi G, Mulpuru SK, DeSimone CV, Viles-Gonzalez J, Deshmukh A
Institution:Harrington Heart and Vascular Institute/Case Western Reserve University, Cleveland, Ohio. Electronic address: Mayo Clinic, Rochester, Minnesota.
Journal:Am J Cardiol. 2020 Dec 15;137:45-54. doi: 10.1016/j.amjcard.2020.09.035. Epub 2020 Sep 28.

14:The counterintuitive role of exercise in the prevention and cause of atrial fibrillation.
Authors:Buckley BJR, Lip GYH, Thijssen DHJ
Institution:Liverpool Centre for Cardiovascular Science, University of Liverpool, Liverpool, United Kingdom. Liverpool Centre for Cardiovascular Science, Liverpool John Moores University, Liverpool, United Kingdom.
Journal:Am J Physiol Heart Circ Physiol. 2020 Nov 1;319(5):H1051-H1058. doi: 10.1152/ajpheart.00509.2020. Epub 2020 Sep 18.

15:Outcomes Associated with Dronedarone Use in Patients with Atrial Fibrillation.
Authors:Goehring EL Jr, Bohn RL, Pezzullo J, Tave AK, Jones JK, Bozzi S, Tamayo RCSG, Sicignano N, Naccarelli GV
Institution:Bausch Health US, LLC, Bridgewater, New Jersey. Penn State University College of Medicine, Hershey, Pennsylvania.
Journal:Am J Cardiol. 2020 Nov 15;135:77-83. doi: 10.1016/j.amjcard.2020.08.026. Epub 2020 Aug 27.

16:Cardiac Rehabilitation for Patients Treated for Atrial Fibrillation With Ablation Has Long-Term Effects: 12-and 24-Month Follow-up Results From the Randomized CopenHeart(RFA) Trial.
Authors:Risom SS, Zwisler AD, Sibilitz KL, Rasmussen TB, Taylor RS, Thygesen LC, Madsen TS, Svendsen JH, Berg SK
Institution:The Heart Centre, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark; Institute of Nursing and Nutrition, University College Copenhagen, Copenhagen, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. Electronic address: The Heart Centre, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark.
Journal:Arch Phys Med Rehabil. 2020 Nov;101(11):1877-1886. doi: 10.1016/j.apmr.2020.06.026. Epub 2020 Aug 1.

17:Safety and efficacy of anticoagulant monotherapy in atrial fibrillation and stable coronary artery disease: A systematic review and meta-analysis.
Authors:Ullah W, Sattar Y, Shaukat M, Fischman DL
Institution:Abington Jefferson Health, Abington, PA, USA. Electronic address: Thomas Jefferson University, Philadelphia, PA, USA.
Journal:Eur J Intern Med. 2020 Nov;81:54-59. doi: 10.1016/j.ejim.2020.06.035. Epub 2020 Jul 22.

18:Postoperative Atrial Fibrillation After Cardiac Surgery: A Systematic Review and Meta-Analysis.
Authors:Eikelboom R, Sanjanwala R, Le ML, Yamashita MH, Arora RC
Institution:Max Rady College of Medicine, University of Manitoba, Winnipeg, Canada. Max Rady College of Medicine, University of Manitoba, Winnipeg, Canada; Cardiac Sciences Program, St. Boniface Hospital, Winnipeg, Manitoba, Canada; Institute of Cardiovascular Sciences, St. Boniface Hospital Research Centre, Winnipeg, Manitoba, Canada. Electronic address:
Journal:Ann Thorac Surg. 2021 Feb;111(2):544-554. doi: 10.1016/j.athoracsur.2020.05.104. Epub 2020 Jul 17.

19:New-onset atrial fibrillation: incidence, characteristics, and related events following a national COVID-19 lockdown of 5.6 million people.
Authors:Holt A, Gislason GH, Schou M, Zareini B, Biering-Sørensen T, Phelps M, Kragholm K, Andersson C, Fosbøl EL, Hansen ML, Gerds TA, Køber L, Torp-Pedersen C, Lamberts M
Institution:Department of Cardiology, Herlev and Gentofte University Hospital, Copenhagen, Denmark.
Journal:Eur Heart J. 2020 Jun 1;41(32):3072-3079. doi: 10.1093/eurheartj/ehaa494.

20:Safety of carotid artery revascularization procedures in patients with atrial fibrillation.
Authors:Nejim B, Mathlouthi A, Weaver L, Faateh M, Arhuidese I, Malas MB
Institution:Division of Vascular and Endovascular Surgery, Penn State Hershey Medical Center, Hershey, Pa. Division of Vascular and Endovascular Surgery, University of California San Diego, La Jolla, Calif. Electronic address:
Journal:J Vasc Surg. 2020 Dec;72(6):2069-2078.e4. doi: 10.1016/j.jvs.2020.01.074. Epub 2020 May 26.

21:The Efficacy of Anti-inflammatory Agents in the Prevention of Atrial Fibrillation Recurrences.
Authors:Nomani H, Saei S, Johnston TP, Sahebkar A, Mohammadpour AH
Institution:School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. Pharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
Journal:Curr Med Chem. 2021;28(1):137-151. doi: 10.2174/1389450121666200302095103.

22:Short-duration triple antithrombotic therapy for atrial fibrillation patients who require coronary stenting: results of the SAFE-A study.
Authors:Hoshi T, Sato A, Hiraya D, Watabe H, Takeyasu N, Nogami A, Ohigashi T, Gosho M, Ieda M, Aonuma K
Institution:Department of Cardiology, Faculty of Medicine, University of Tsukuba, Tsukuba City, Ibaraki, Japan.
Journal:EuroIntervention. 2020 Jun 12;16(2):e164-e172. doi: 10.4244/EIJ-D-19-00920.

23:Improved oral hygiene care is associated with decreased risk of occurrence for atrial fibrillation and heart failure: A nationwide population-based cohort study.
Authors:Chang Y, Woo HG, Park J, Lee JS, Song TJ
Institution:Department of Neurology, Mokdong Hospital, Ewha Womans University College of Medicine, Korea.
Journal:Eur J Prev Cardiol. 2020 Nov;27(17):1835-1845. doi: 10.1177/2047487319886018. Epub 2019 Dec 1.

24:The convergent procedure: a hybrid approach for long lasting persistent atrial fibrillation ablation.
Authors:Zannis K, Alam W, Sebag FA, Folliguet T, Bars C, Fahed M, Ternacle J, Bergoend E, Hamon D, Lellouche N
Institution:Unit of Cardiac Surgery, Institut Mutualiste Montsouris (IMM), Paris, France - Henri Mondor Hospital, Assistance Publique Hopitaux de Paris et INSERM U 955, Creteil, France.
Journal:J Cardiovasc Surg (Torino). 2020 Jun;61(3):369-375. doi: 10.23736/S0021-9509.19.10701-X. Epub 2019 Oct 9.

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