Atrial Fibrillation
December 2017 Issue
 
 
 

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Atrial Fibrillation abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Atrial Fibrillation. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Atrial Fibrillation. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Atrial Fibrillation every 3 months. Thank you for your ongoing subscription to this publication.

Sincerely,
Elliot Jacob, Ph.D.
Vice-President - Content
Medifocus.com, Inc.



1:STABLE-SR (Electrophysiological Substrate Ablation in the Left Atrium During Sinus Rhythm) for the Treatment of Nonparoxysmal Atrial Fibrillation: A Prospective, Multicenter Randomized Clinical Trial.
Authors:Yang B, Jiang C, Lin Y, Yang G, Chu H, Cai H, Lu F, Zhan X, Xu J, Wang X, Ching CK, Singh B, Kim YH, Chen M
Institution:From the Department of Cardiology, First Affiliated Hospital of Nanjing Medical University, China (B.Y., G.Y., M.C.); Department of Cardiology Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China (C.J.); Department of Cardiology, Fujian Provincial Hospital, Fujian Medical University, Fuzhou, China (Y.L.); Department of Cardiology, Ningbo First Hospital, Zhejiang University, Ningbo, China (H. Chu); Department of Cardiology, General Hospital, Tianjin Medical University, China (H. Cai); Department of Cardiology, Tianjin Chest Hospital, China (F.L.); Department of Cardiology, Guangdong Province People's Hospital, Guangzhou, China (X.Z.); Department of Cardiology, Anhui Provincial Hospital, Hefei, China (J.X.); Department of Cardiology, Renji Hospital, Shanghai Jiaotong University, China (X.W.); Department of Cardiology, National Heart Centre Singapore (C.-K.C.); Department of Electrophysiology and Cardiac Pacing, Medanta, The Medicity Hospital, Gurgaon, Haryana, India (B.S.); and Department of Cardiology, Korea University Hospital, Seoul (Y.-H.K.). chenminglong@njmu.edu.cn.
Journal:Circ Arrhythm Electrophysiol. 2017 Nov;10(11). pii: CIRCEP.117.005405. doi: 10.1161/CIRCEP.117.005405.

2:Treatment of Atrial Fibrillation and Concordance With the American Heart Association/American College of Cardiology/Heart Rhythm Society Guidelines: Findings From ORBIT-AF (Outcomes Registry for Better Informed Treatment of Atrial Fibrillation).
Authors:Barnett AS, Kim S, Fonarow GC, Thomas LE, Reiffel JA, Allen LA, Freeman JV, Naccarelli G, Mahaffey KW, Go AS, Kowey PR, Ansell JE, Gersh BJ, Hylek EM, Peterson ED, Piccini JP
Institution:From the Duke Center for Atrial Fibrillation, Duke Clinical Research Institute, Duke University Medical Center, Durham, NC (A.S.B., S.K., L.E.T., E.D.P., J.P.P.); Ahmanson-UCLA Cardiomyopathy Center, Ronald Reagan-UCLA Medical Center (G.C.F.); Columbia University College of Physicians and Surgeons, New York, NY (J.A.R.); University of Colorado School of Medicine, Aurora (L.A.A.); Yale University School of Medicine, New Haven, CT (J.V.F.); Penn State Hershey Heart and Vascular Institute (G.N.); Stanford University School of Medicine, CA (K.W.M.); Kaiser Permanente Division of Research, Oakland, CA (A.S.G.); Lankenau Institute for Medical Research and Jefferson Medical College, Philadelphia, PA (P.R.K.); Hofstra Northwell School of Medicine, New York, NY (J.E.A.); Mayo Clinic and Mayo Clinic College of Medicine, Rochester, MN (B.J.G.); and Boston University Medical Center, MA (E.M.H.). jonathan.piccini@duke.edu adam.barnett@duke.edu.
Journal:Circ Arrhythm Electrophysiol. 2017 Nov;10(11). pii: CIRCEP.117.005051. doi: 10.1161/CIRCEP.117.005051.

3:Minimally Invasive Stand-Alone Cox Maze Procedure for Persistent and Long-Standing Persistent Atrial Fibrillation: Perioperative Safety and 5-Year Outcomes.
Authors:Ad N, Holmes SD, Friehling T
Institution:From the Department of Cardiovascular and Thoracic Surgery, West Virginia University, Morgantown (N.A.); Washington Adventist Hospital, Takoma Park, MD (N.A.); Inova Fairfax Hospital, Falls Church, VA (N.A.); WVU Heart and Vascular Institute, West Virginia University, Morgantown (S.D.H.); and Inova Medical Group, Fairfax, VA (T.F.). nivadmd14@gmail.com.
Journal:Circ Arrhythm Electrophysiol. 2017 Nov;10(11). pii: CIRCEP.117.005352. doi: 10.1161/CIRCEP.117.005352.

4:Predictors of sudden cardiac death in atrial fibrillation: The Atherosclerosis Risk in Communities (ARIC) study.
Authors:Koene RJ, Norby FL, Maheshwari A, Rooney MR, Soliman EZ, Alonso A, Chen LY
Institution:Cardiovascular Division, Department of Medicine, University of Minnesota Medical School, Minneapolis, Minnesota, United States of America. University of Minnesota, Minneapolis, Minnesota, United States of America. School, Minneapolis, Minnesota, United States of America. University of Minnesota, Minneapolis, Minnesota, United States of America. and Prevention, and Department of Internal Medicine-Cardiology, Wake Forest School of Medicine, Winston Salem, North Carolina, United States of America. Atlanta, Georgia, United States of America. School, Minneapolis, Minnesota, United States of America.
Journal:PLoS One. 2017 Nov 8;12(11):e0187659. doi: 10.1371/journal.pone.0187659. eCollection 2017.

5:Obesity and Atrial Fibrillation Prevalence, Pathogenesis, and Prognosis: Effects of Weight Loss and Exercise.
Authors:Lavie CJ, Pandey A, Lau DH, Alpert MA, Sanders P
Institution:Department of Cardiovascular Diseases, John Ochsner Heart and Vascular Institute, Ochsner Clinical School-The University of Queensland School of Medicine, New Orleans, Louisiana. Electronic address: clavie@ochsner.org. Texas. Institution, University of Adelaide and Royal Adelaide Hospital, Adelaide, Australia. Columbia, Missouri. Institution, University of Adelaide and Royal Adelaide Hospital, Adelaide, Australia.
Journal:J Am Coll Cardiol. 2017 Oct 17;70(16):2022-2035. doi: 10.1016/j.jacc.2017.09.002.

6:Association Between Use of Non-Vitamin K Oral Anticoagulants With and Without Concurrent Medications and Risk of Major Bleeding in Nonvalvular Atrial Fibrillation.
Authors:Chang SH, Chou IJ, Yeh YH, Chiou MJ, Wen MS, Kuo CT, See LC, Kuo CF
Institution:Cardiovascular Department, Chang Gung Memorial Hospital, Taoyuan, Taiwan. Taoyuan, Taiwan. Taoyuan, Taiwan. Laboratory, Molecular Medicine Research Centre, Chang Gung University, Taoyuan, Taiwan. Taoyuan, Taiwan. Taoyuan, Taiwan. Taoyuan, Taiwan. University of Nottingham, Nottingham, United Kingdom.
Journal:JAMA. 2017 Oct 3;318(13):1250-1259. doi: 10.1001/jama.2017.13883.

7:Efficacy and safety of dronedarone in the treatment of patients with atrial fibrillation.
Authors:Khan MH, Rochlani Y, Aronow WS
Institution:a The Cardiology Division, Department of Medicine , Westchester Medical Center and New York Medical College , Valhalla , NY , USA.
Journal:Expert Opin Drug Saf. 2017 Dec;16(12):1407-1412. doi: 10.1080/14740338.2017.1387246. Epub 2017 Oct 6.

8:Predicting Major Bleeding in Ischemic Stroke Patients With Atrial Fibrillation.
Authors:Hilkens NA, Algra A, Greving JP
Institution:From the Julius Center for Health Sciences and Primary Care (N.A.H., A.A., J.P.G.) and Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus (A.A.), University Medical Center Utrecht, Utrecht University, the Netherlands. n.a.hilkens-3@umcutrecht.nl.
Journal:Stroke. 2017 Nov;48(11):3142-3144. doi: 10.1161/STROKEAHA.117.019183. Epub 2017 Sep 20.

9:Effect of Ablation for Atrial Fibrillation on Heart Failure Readmission Rates.
Authors:Joy PS, Gopinathannair R, Olshansky B
Institution:Department of Medicine, University of Iowa Hospitals and Clinics, Iowa City, Iowa. Electronic address: parijat-joy@uiowa.edu. Iowa.
Journal:Am J Cardiol. 2017 Nov 1;120(9):1572-1577. doi: 10.1016/j.amjcard.2017.07.057. Epub 2017 Jul 31.

10:Comparison of the Effectiveness and Safety of Apixaban, Dabigatran, Rivaroxaban, and Warfarin in Newly Diagnosed Atrial Fibrillation.
Authors:Hernandez I, Zhang Y, Saba S
Institution:Department of Pharmacy and Therapeutics, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania. Electronic address: inh3@pitt.edu. University of Pittsburgh, Pittsburgh, Pennsylvania. Pittsburgh, Pennsylvania.
Journal:Am J Cardiol. 2017 Nov 15;120(10):1813-1819. doi: 10.1016/j.amjcard.2017.07.092. Epub 2017 Aug 8.

11:The safety of edoxaban for treating atrial fibrillation.
Authors:Hammwohner M, Goette A
Institution:a Department of Cardiology and Intensive Care, Medicine , St.Vincenz-Krankenhaus Paderborn , Paderborn , Germany. Paderborn , Paderborn , Germany.
Journal:Expert Opin Drug Saf. 2017 Nov;16(11):1295-1303. doi: 10.1080/14740338.2017.1372418. Epub 2017 Sep 18.

12:Catheter Ablation Versus Medical Rate Control in Atrial Fibrillation and Systolic Dysfunction: The CAMERA-MRI Study.
Authors:Prabhu S, Taylor AJ, Costello BT, Kaye DM, McLellan AJA, Voskoboinik A, Sugumar H, Lockwood SM, Stokes MB, Pathik B, Nalliah CJ, Wong GR, Azzopardi SM, Gutman SJ, Lee G, Layland J, Mariani JA, Ling LH, Kalman JM, Kistler PM
Institution:The Baker Heart & Diabetes Institute, Clinical Electrophysiology Research, Melbourne, Australia; The Heart Centre, The Alfred Hospital, Melbourne, Australia; Department of Cardiology, Royal Melbourne Hospital, Melbourne, Australia; Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, Australia.; The Baker Heart & Diabetes Institute, Clinical Electrophysiology Research, Melbourne, Australia; The Heart Centre, The Alfred Hospital, Melbourne, Australia; Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Australia.; The Baker Heart & Diabetes Institute, Clinical Electrophysiology Research, Melbourne, Australia; The Heart Centre, The Alfred Hospital, Melbourne, Australia.; MonashHeart, Monash Medical Centre, Melbourne, Australia.; Department of Cardiology, Royal Melbourne Hospital, Melbourne, Australia.
Journal:J Am Coll Cardiol. 2017 Oct 17;70(16):1949-1961. doi: 10.1016/j.jacc.2017.08.041. Epub 2017 Aug 27.

13:Use of direct oral anticoagulants for stroke prevention in elderly patients with nonvalvular atrial fibrillation.
Authors:Oertel LB, Fogerty AE
Institution:Anticoagulant Management Service, Department of Nursing, Massachusetts General Hospital, Boston, Massachusetts.
Journal:J Am Assoc Nurse Pract. 2017 Sep;29(9):551-561. doi: 10.1002/2327-6924.12494. Epub 2017 Aug 14.

14:Effect of Dietary Intake of Saturated Fatty Acids on the Development of Atrial Fibrillation and the Effect of Replacement of Saturated With Monounsaturated and Polyunsaturated Fatty Acids.
Authors:Dinesen PT, Joensen AM, Rix TA, Tjonneland A, Schmidt EB, Lundbye-Christensen S, Overvad K
Institution:Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark; Aalborg AF Study Group, Aalborg University Hospital, Aalborg, Denmark. Electronic address: p.dinesen@rn.dk. Copenhagen, Denmark. of Clinical Medicine, Aalborg University, Aalborg, Denmark. Clinical Biostatistics, Aalborg University, Aalborg, Denmark. AF Study Group, Aalborg University Hospital, Aalborg, Denmark; Department of Public Health, Section for Epidemiology, Aarhus University, Aarhus, Denmark.
Journal:Am J Cardiol. 2017 Oct 1;120(7):1129-1132. doi: 10.1016/j.amjcard.2017.06.053. Epub 2017 Jul 14.

15:Modifiable Risk Factors and Atrial Fibrillation.
Authors:Lau DH, Nattel S, Kalman JM, Sanders P
Institution:From: Centre for Heart Rhythm Disorders, South Australian Health and Medical Research Institute, University of Adelaide and Royal Adelaide Hospital, (D.H.L., P.S.); Department of Medicine, Universite de Montreal, Research Center, Montreal Heart Institute, Quebec, Canada (S.N.); Institute of Pharmacology, West German Heart and Vascular Center, Faculty of Medicine, University Duisburg-Essen, Germany (S.N.); and Department of Cardiology, Royal Melbourne Hospital and the Department of Medicine, University of Melbourne, Victoria, Australia (J.M.K.). prash.sanders@adelaide.edu.au.
Journal:Circulation. 2017 Aug 8;136(6):583-596. doi: 10.1161/CIRCULATIONAHA.116.023163.

16:Subclinical Atrial Fibrillation in Older Patients.
Authors:Healey JS, Alings M, Ha A, Leong-Sit P, Birnie DH, de Graaf JJ, Freericks M, Verma A, Wang J, Leong D, Dokainish H, Philippon F, Barake W, McIntyre WF, Simek K, Hill MD, Mehta SR, Carlson M, Smeele F, Pandey AS, Connolly SJ
Institution:From Population Health Research Institute, Hamilton, ON, Canada (J.S.H., J.W., D.L., H.D., K.S., S.R.M., S.J.C.); McMaster University, Hamilton, ON, Canada (J.S.H., J.W., D.L., H.D., W.F.M., S.R.M., A.S.P., S.J.C.); Amphia Ziekenhuis, Breda, the Netherlands (M.A.); WCN-Dutch Network for Cardiovascular Research (M.A.); University of Toronto, ON, Canada (A.H., A.V.); University of Western Ontario, London, Canada (P.L.-S.); University of Ottawa Heart Institute, ON, Canada (D.H.B.); Nij Smellinghe Hospital, Drachten, the Netherlands (J.J.d.G.); Ikazia Ziekenhuis, Rotterdam, the Netherlands (M.F.); Institut Universitaire de Cardiologie et de Pneumologie de Quebec, QC, Canada (F.P.); University of Alberta, Edmonton, Canada (W.B.); University of Calgary, AB, Canada (M.D.H.); St. Jude Medical, Sylmar, CA (M.C.); Slingeland Ziekenhuis, Doetinchem, the Netherlands (F.S.); and Cambridge Cardiac Care Centre, ON, Canada (A.S.P.). Jeff.Healey@phri.ca.
Journal:Circulation. 2017 Oct 3;136(14):1276-1283. doi: 10.1161/CIRCULATIONAHA.117.028845. Epub 2017 Aug 4.

17:Should We Perform Catheter Ablation for Asymptomatic Atrial Fibrillation?
Authors:Kalman JM, Sanders P, Rosso R, Calkins H
Institution:From Department of Cardiology, Royal Melbourne Hospital, Parkville, Australia (J.M.K.); Faculty of Medicine, Dentistry, and Health Sciences, University of Melbourne, Australia (J.M.K.); Centre for Heart Rhythm Disorders, South Australian Health and Medical Research Institute, University of Adelaide and Royal Adelaide Hospital, Australia (P.S.); Department of Cardiology, Tel Aviv Sourasky Medical Center, Sackler School of Medicine, Tel Aviv University, Israel (R.S.); and Department of Medicine, Division of Cardiology, Johns Hopkins University, Baltimore, MD (H.C.). jon.kalman@mh.org.au.
Journal:Circulation. 2017 Aug 1;136(5):490-499. doi: 10.1161/CIRCULATIONAHA.116.024926.

18:Time in therapeutic range and major adverse outcomes in atrial fibrillation patients undergoing percutaneous coronary intervention: The Atrial Fibrillation Undergoing Coronary Artery Stenting (AFCAS) registry.
Authors:Proietti M, Airaksinen KEJ, Rubboli A, Schlitt A, Kiviniemi T, Karjalainen PP, Lip GY
Institution:Institute of Cardiovascular Sciences, University of Birmingham, Birmingham, United Kingdom. Maggiore, Bologna, Italy. United Kingdom; Aalborg Thrombosis Research Unit, Department of Clinical Medicine, Aalborg University, Aalborg, Denmark. Electronic address: g.y.h.lip@bham.ac.uk.
Journal:Am Heart J. 2017 Aug;190:86-93. doi: 10.1016/j.ahj.2017.05.016. Epub 2017 Jun 3.

19:Effects of Smoking on Ischemic Stroke, Intracranial Hemorrhage, and Coronary Artery Events in Japanese Patients With Non-Valvular Atrial Fibrillation.
Authors:Suzuki S, Otsuka T, Sagara K, Semba H, Kano H, Matsuno S, Takai H, Kato Y, Uejima T, Oikawa Y, Nagashima K, Kirigaya H, Yajima J, Kunihara T, Sawada H, Aizawa T, Yamashita T
Institution:Department of Cardiovascular Medicine, The Cardiovascular Institute.
Journal:Int Heart J. 2017 Aug 3;58(4):506-515. doi: 10.1536/ihj.16-228. Epub 2017 Jul 13.

20:Surgical Ablation of Atrial Fibrillation in the United States: Trends and Propensity Matched Outcomes.
Authors:Badhwar V, Rankin JS, Ad N, Grau-Sepulveda M, Damiano RJ, Gillinov AM, McCarthy PM, Thourani VH, Suri RM, Jacobs JP, Cox JL
Institution:Department of Cardiovascular and Thoracic Surgery, West Virginia University, Morgantown, West Virginia. Electronic address: vinay.badhwar@wvumedicine.org. Morgantown, West Virginia. Morgantown, West Virginia. Ohio. Chicago, Illinois. Ohio. Baltimore, Maryland. Chicago, Illinois.
Journal:Ann Thorac Surg. 2017 Aug;104(2):493-500. doi: 10.1016/j.athoracsur.2017.05.016. Epub 2017 Jun 29.

21:Considerations and treatment options for patients with comorbid atrial fibrillation and diabetes mellitus.
Authors:Moss AS, Dimitropoulos G, Connolly DL, Lip GYH
Institution:a Institute of Cardiovascular Sciences , University of Birmingham , Birmingham , United Kingdom. United Kingdom. United Kingdom. University , Aalborg , Denmark.
Journal:Expert Opin Pharmacother. 2017 Aug;18(11):1101-1114. doi: 10.1080/14656566.2017.1350647. Epub 2017 Jul 10.

22:Modifiable Risk Factors in Atrial Fibrillation: The Role of Alcohol, Obesity, and Sleep Apnea.
Authors:Sidhu K, Tang A
Institution:Department of Cardiology, Western University, London, Ontario, Canada. Electronic address: kdsidhu26@gmail.com.
Journal:Can J Cardiol. 2017 Jul;33(7):947-949. doi: 10.1016/j.cjca.2017.04.006. Epub 2017 Apr 21.

23:Treating Specialty and Outcomes in Newly Diagnosed Atrial Fibrillation: From the TREAT-AF Study.
Authors:Perino AC, Fan J, Schmitt SK, Askari M, Kaiser DW, Deshmukh A, Heidenreich PA, Swan C, Narayan SM, Wang PJ, Turakhia MP
Institution:Department of Medicine, Stanford University School of Medicine, Stanford, California; Veterans Affairs Palo Alto Health Care System, Palo Alto, California.; Mayo Clinic, Rochester, Minnesota.; Department of Medicine, Stanford University School of Medicine, Stanford, California; Veterans Affairs Palo Alto Health Care System, Palo Alto, California; Center for Digital Health, Stanford University School of Medicine, Stanford, California. Electronic address: mintu@stanford.edu.
Journal:J Am Coll Cardiol. 2017 Jul 4;70(1):78-86. doi: 10.1016/j.jacc.2017.04.054.

24:Effectiveness and Safety of Apixaban, Dabigatran, and Rivaroxaban Versus Warfarin in Patients With Nonvalvular Atrial Fibrillation and Previous Stroke or Transient Ischemic Attack.
Authors:Coleman CI, Peacock WF, Bunz TJ, Alberts MJ
Institution:From the University of Connecticut School of Pharmacy, Storrs (C.I.C.); Department of Emergency Medicine, Baylor College of Medicine, Houston, TX (W.F.P.); Crystal Run Healthcare, Middletown, NY (T.J.B.); Ayer Neuroscience Institute, Hartford HealthCare, CT (M.J.A.); and Department of Neurology, Hartford Hospital, CT (M.J.A.). craig.coleman@hhchealth.org.
Journal:Stroke. 2017 Aug;48(8):2142-2149. doi: 10.1161/STROKEAHA.117.017474. Epub 2017 Jun 27.

25:Predictors, Prognosis, and Management of New Clinically Important Atrial Fibrillation After Noncardiac Surgery: A Prospective Cohort Study.
Authors:Alonso-Coello P, Cook D, Xu SC, Sigamani A, Berwanger O, Sivakumaran S, Yang H, Xavier D, Martinez LX, Ibarra P, Rao-Melacini P, Pogue J, Zarnke K, Paniagua P, Ostrander J, Yusuf S, Devereaux PJ
Institution:From the *Biomedical Research Institute Sant Pau (IIB Sant Pau), CIBER Epidemiologia y Salud Publica (CIBERESP), Barcelona, Spain; Departments of daggerMedicine and Clinical Epidemiology and double daggerBiostatistics, McMaster University, Hamilton, Ontario, Canada; section signHypertension League Institute, Beijing, China; ||Department of Clinical Research, Narayana Hrudyalaya Limited, Bangalore, India; paragraph signResearch Institute HCor (Heart Hospital-Hospital do Coracao), Sao Paulo, Brazil; #Department of Medicine, University of Alberta, Edmonton, Alberta, Canada; **Department of Anaesthesia, University of Ottawa, Ontario, Canada; daggerdaggerSt John's Medical College and St John's Research Institute, Bangalore, India; double daggerdouble daggerDepartment of Medicine, Universidad Autonoma de Bucaramanga, Bucaramanga, Colombia; section sign section signDepartment of Anaesthesia, Clinica Reina Sofia, Bogota, Colombia; || ||Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada; paragraph sign paragraph signDepartment of Medicine, University of Calgary, Alberta, Canada; ##Department of Anesthesiology, Hospital de la Sta Creu i Sant Pau, Barcelona, Spain; ***Department of Medicine, Grey Bruce Health Sciences, Owen Sound, Ontario, Canada; and daggerdaggerdaggerPopulation Health Research Institute, McMaster University, Hamilton, Ontario, Canada.
Journal:Anesth Analg. 2017 Jul;125(1):162-169. doi: 10.1213/ANE.0000000000002111.

26:Causes of death in atrial fibrillation: Challenges and opportunities.
Authors:Gomez-Outes A, Suarez-Gea ML, Garcia-Pinilla JM
Institution:Division of Pharmacology and Clinical Drug Evaluation, Agencia Espanola de Medicamentos y Productos Sanitarios (AEMPS), Campezo 1, 28022 Madrid, Spain. Electronic address: agomezo@aemps.es. Medicamentos y Productos Sanitarios (AEMPS), Campezo 1, 28022 Madrid, Spain. (IBIMA), Hospital Universitario Virgen de la Victoria, Malaga, Spain; Centro de Investigacion Biomedica en Red-Cardiovascular (CIBER-CV), Instituto de Salud Carlos III, Madrid, Spain.
Journal:Trends Cardiovasc Med. 2017 Oct;27(7):494-503. doi: 10.1016/j.tcm.2017.05.002. Epub 2017 May 10.

27:Gene Therapy for Atrial Fibrillation in Heart Failure.
Authors:Arora R
Institution:Department of Experimental Cardiac Electrophysiology, Northwestern University, Feinberg School of Medicine, Northwestern Memorial Hospital, Chicago, Illinois, USA.
Journal:Clin Pharmacol Ther. 2017 Aug;102(2):200-202. doi: 10.1002/cpt.717. Epub 2017 May 26.

28:Chocolate intake and risk of clinically apparent atrial fibrillation: the Danish Diet, Cancer, and Health Study.
Authors:Mostofsky E, Berg Johansen M, Tjonneland A, Chahal HS, Mittleman MA, Overvad K
Institution:Cardiovascular Epidemiology Research Unit, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA. Massachusetts, USA. Dentistry, Western University, London, Ontario, Canada. Boston, Massachusetts, USA. Massachusetts, USA. Denmark.
Journal:Heart. 2017 Aug;103(15):1163-1167. doi: 10.1136/heartjnl-2016-310357. Epub 2017 May 23.

29:Renal Function Considerations for Stroke Prevention in Atrial Fibrillation.
Authors:Fanikos J, Burnett AE, Mahan CE, Dobesh PP
Institution:Department of Pharmacy, Brigham and Women's Hospital, Boston, Mass. Electronic address: jfanikos@partners.org. Albuquerque. Presbyterian Healthcare Services, Albuquerque.
Journal:Am J Med. 2017 Sep;130(9):1015-1023. doi: 10.1016/j.amjmed.2017.04.015. Epub 2017 May 11.

30:Appropriateness of Oral Anticoagulants for the Long-Term Treatment of Atrial Fibrillation in Older People: Results of an Evidence-Based Review and International Consensus Validation Process (OAC-FORTA 2016).
Authors:Wehling M, Collins R, Gil VM, Hanon O, Hardt R, Hoffmeister M, Monteiro P, Quinn TJ, Ropers D, Sergi G, Verheugt FWA
Institution:Institute for Experimental and Clinical Pharmacology and Toxicology, Medical Faculty Mannheim, Ruprecht-Karls-University Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany. martin.wehling@medma.uni-heidelberg.de. Universite Paris Descartes, Sorbonne, Paris, France. Germany. Royal Infirmary, Glasgow, UK. Nuremberg, Nuremberg, Germany.
Journal:Drugs Aging. 2017 Jul;34(7):499-507. doi: 10.1007/s40266-017-0466-6.

31:The Population-Based Long-Term Impact of Anticoagulant and Antiplatelet Therapies in Low-Risk Patients With Atrial Fibrillation.
Authors:Golive A, May HT, Bair TL, Jacobs V, Crandall BG, Cutler MJ, Day JD, Mallender C, Osborn JS, Stevens SM, Weiss JP, Woller SC, Bunch TJ
Institution:Intermountain Medical Center Heart Institute, Intermountain Medical Center, Murray, Utah.; Intermountain Medical Center Heart Institute, Intermountain Medical Center, Murray, Utah; Department of Internal Medicine, Stanford University, Palo Alto, California. Electronic address: thomas.bunch@imail.org.
Journal:Am J Cardiol. 2017 Jul 1;120(1):75-82. doi: 10.1016/j.amjcard.2017.03.256. Epub 2017 Apr 12.

32:Thromboembolic and bleeding risks in patients undergoing atrial fibrillation ablation: oral anticoagulation perspectives.
Authors:Briceno DF, Madan N, Romero J, Londono A, Villablanca PA, Natale A, Di Biase L
Institution:a Division of Cardiovascular Disease , Montefiore Medical Center, Albert Einstein College of Medicine , Bronx , NY , USA.; b Texas Cardiac Arrhythmia Institute, Heart & Vascular Department , St. David's Medical Center , Austin , TX , USA.
Journal:Expert Opin Drug Saf. 2017 Jul;16(7):769-777. doi: 10.1080/14740338.2017.1325867. Epub 2017 Jun 15.

33:Viewpoint: Stroke Prevention in Recent Guidelines for the Management of Patients with Atrial Fibrillation: An Appraisal.
Authors:Potpara TS, Lip GYH, Blomstrom-Lundqvist C, Chiang CE, Camm AJ
Institution:School of Medicine, Belgrade University, Serbia; Cardiology Clinic, Clinical Center of Serbia, Belgrade. Sciences, University of Birmingham, United Kingdom; Aalborg Thrombosis Research Unit, Department of Clinical Medicine, Aalborg University, Denmark. Electronic address: g.y.h.lip@bham.ac.uk. Sweden. General Hospital and National Yang-Ming University, Taiwan. Kingdom.
Journal:Am J Med. 2017 Jul;130(7):773-779. doi: 10.1016/j.amjmed.2017.02.026. Epub 2017 Mar 24.

34:Long-Term Risk of Ischemic Stroke After the Cox-Maze III Procedure for Atrial Fibrillation.
Authors:Albage A, Sartipy U, Kenneback G, Johansson B, Schersten H, Jideus L
Institution:Department of Cardiothoracic Surgery, University Hospital, Uppsala, Sweden. Electronic address: anders.albage@akademiska.se. Hospital, Stockholm, Sweden; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden. Gothenburg, Sweden. Hospital/Sahlgrenska, Gothenburg, Sweden.
Journal:Ann Thorac Surg. 2017 Aug;104(2):523-529. doi: 10.1016/j.athoracsur.2016.11.065. Epub 2017 Feb 24.

35:Gender differences in clinical presentation and 1-year outcomes in atrial fibrillation.
Authors:Schnabel RB, Pecen L, Ojeda FM, Lucerna M, Rzayeva N, Blankenberg S, Darius H, Kotecha D, Caterina R, Kirchhof P
Institution:Department of Cardiology, University Heart Center Hamburg-Eppendorf, German Center for Cardiovascular Research (DZHK) partner site Hamburg/Kiel/Lubeck, Hamburg, Germany.; Medical Facility Pilsen of Charles University, Pilsen, Czech Republic.; Daiichi Sankyo Europe GmbH, Munich, Germany.; Department of Cardiology, Angiology, Nephrology and Conservative Intensive Care Medicine, Vivantes Klinikum Neukolln, Berlin, Germany.; School of Clinical & Experimental Medicine, University of Birmingham, Birmingham, UK.
Journal:Heart. 2017 Jul;103(13):1024-1030. doi: 10.1136/heartjnl-2016-310406. Epub 2017 Feb 22.

36:Safety and efficacy of contemporary catheter ablation for atrial fibrillation patients with a history of cardioembolic stroke in the era of direct oral anticoagulants.
Authors:Nishizaki K, Itoh T, Kimura M, Tsushima Y, Shoji Y, Kinjo T, Ishida Y, Sasaki K, Horiuchi D, Sasaki S, Tomita H, Okumura K
Institution:Department of Cardiology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan. Hirosaki, Japan. School of Medicine, Hirosaki, Japan. Hirosaki, Japan. Hirosaki, Japan. Hirosaki, Japan. Hirosaki, Japan. Hirosaki, Japan. Graduate School of Medicine, Hirosaki, Japan. Graduate School of Medicine, Hirosaki, Japan. Hirosaki, Japan; Department of Hypertension and Stroke Medicine, Hirosaki University Graduate School of Medicine, Hirosaki, Japan. address: okumura@hirosaki-u.ac.jp.
Journal:J Cardiol. 2017 Jul;70(1):86-91. doi: 10.1016/j.jjcc.2016.10.001. Epub 2016 Nov 3.

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What Our Customers Are Saying...

"The MediFocus Guidebook on Atrial Fibrillation has enhanced and clearly explained this condition for me. It has also enabled me to make choices with confidence regarding my treatment. The references in the medical literature section has put me in touch with the research base in this country. Many thanks."
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