Atrial Fibrillation
November 2019 Issue

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Atrial Fibrillation abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Atrial Fibrillation. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Atrial Fibrillation. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Atrial Fibrillation every 3 months. Thank you for your ongoing subscription to this publication.

Elliot Jacob, Ph.D.
Vice-President - Content, Inc.

1:Effects of CHADS2 score, echocardiographic and haematologic parameters on stroke severity and prognosis in patients with stroke due to nonvalvular atrial fibrillation.
Authors:Aynaci O, Tekatas A, Aynaci G, Kehaya S, Utku U
Institution:Trakya University, Medical Faculty, Department of Neurology, Edirne, Turkey. Turkey.
Journal:Ideggyogy Sz. 2019 Jul 30;72(7-8):241-256. doi: 10.18071/isz.72.0241.

2:Antiarrhythmics for maintaining sinus rhythm after cardioversion of atrial fibrillation.
Authors:Valembois L, Audureau E, Takeda A, Jarzebowski W, Belmin J, Lafuente-Lafuente C
Institution:Service de Geriatrie a Orientation Cardiologique et Neurologique, Groupe Hospitalier Pitie-Salpetriere-Charles Foix, AP-HP, Universite Pierre et Marie Curie, 7 avenue de la Republique, Ivry-sur-Seine, France, 94200.
Journal:Cochrane Database Syst Rev. 2019 Sep 4;9:CD005049. doi: 10.1002/14651858.CD005049.pub5.

3:Antithrombotic Therapy for Atrial Fibrillation with Stable Coronary Disease.
Authors:Yasuda S, Kaikita K, Akao M, Ako J, Matoba T, Nakamura M, Miyauchi K, Hagiwara N, Kimura K, Hirayama A, Matsui K, Ogawa H
Institution:From the National Cerebral and Cardiovascular Center, Suita (S.Y., H.O.), the Department of Cardiology, Osaka Police Hospital, Osaka (A.H.), the Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University (K. Kaikita), and the Department of General Medicine, Kumamoto University Hospital (K. Matsui), Kumamoto, the Department of Cardiology, National Hospital Organization Kyoto Medical Center, Kyoto (M.A.), the Department of Cardiovascular Medicine, Kitasato University School of Medicine, Sagamihara (J.A.), the Department of Cardiovascular Medicine, Kyushu University Hospital, Fukuoka (T.M.), the Division of Cardiovascular Medicine, Toho University Ohashi Medical Center (M.N.), the Department of Cardiology, Juntendo University School of Medicine (K. Miyauchi), and the Department of Cardiology, Tokyo Women's Medical University (N.H.), Tokyo, and the Cardiovascular Center, Yokohama City University Medical Center, Yokohama (K. Kimura) - all in Japan.
Journal:N Engl J Med. 2019 Sep 19;381(12):1103-1113. doi: 10.1056/NEJMoa1904143. Epub 2019 Sep 2.

4:Early Versus Late New-Onset Atrial Fibrillation in Acute Myocardial Infarction: Differences in Clinical Characteristics and Predictors.
Authors:Shiyovich A, Axelrod M, Gilutz H, Plakht Y
Institution:1 Department of Cardiology, Rabin Medical Center, Beilinson Hospital, Petah-Tikva, and "Sackler" Faculty of Medicine, Tel-Aviv University Israel, Tel Aviv-Yafo, Israel. the Negev, Beer-Sheva, Israel. the Negev, Beer-Sheva, Israel. the Negev, Beer-Sheva, Israel. Negev, and Soroka University Medical Center, Beer-Sheva, Israel.
Journal:Angiology. 2019 Nov;70(10):921-928. doi: 10.1177/0003319719867542. Epub 2019 Aug 6.

5:Arrhythmias in Congenital Heart Disease.
Authors:Kline J, Costantini O
Institution:Summa Health Heart & Vascular Institute, Summa Health System, 95 Arch Street, Suite 300, Akron, OH 44304, USA. Health System, 95 Arch Street, Suite 350, Akron, OH 44304, USA. Electronic address:
Journal:Med Clin North Am. 2019 Sep;103(5):945-956. doi: 10.1016/j.mcna.2019.04.007.

6:Stroke Prevention in Atrial Fibrillation: The Role of Oral Anticoagulation.
Authors:Mtwesi V, Amit G
Institution:Division of Cardiology, Department of Medicine, McMaster University, Hamilton General Hospital, 237 Barton Street East, Hamilton, Ontario L8L 2X2, Canada. Electronic address:
Journal:Med Clin North Am. 2019 Sep;103(5):847-862. doi: 10.1016/j.mcna.2019.05.006.

7:Pharmacologic and Nonpharmacologic Management of Atrial Fibrillation.
Authors:Dahya V, Taigen TL
Institution:Cardiovascular Disease, Summa Health System, NEOMED University, Akron City Hospital, 95 Arch Street, Suite 300, Akron, OH 44304, USA. Heart and Vascular Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue/J2, Cleveland, OH 44195, USA. Electronic address:
Journal:Med Clin North Am. 2019 Sep;103(5):835-846. doi: 10.1016/j.mcna.2019.04.004. Epub 2019 Jul 1.

8:Oral anticoagulant prescribing in elderly patients above and below age 80 with atrial fibrillation.
Authors:Xie K, Shen J, Xiong N, Li J, Ni H, Yuan F, Zhang J, Chen H, Gao W, Jiang X, Luo X
Journal:Int J Clin Pharmacol Ther. 2019 Sep;57(9):458-463. doi: 10.5414/CP203502.

9:Adverse Clinical Events during Long-Term Follow-Up After Catheter Ablation of Atrial Fibrillation.
Authors:Arai M, Okumura Y, Nagashima K, Watanabe I, Watanabe R, Wakamatsu Y, Otsuka N, Yagyu S, Kurokawa S, Ohkubo K, Nakai T, Yokoyama K, Ikeda A, Matsumoto N, Kunimoto S, Tachibana E, Iso K, Nomoto K, Tosaka T, Sonoda K, Hirayama A
Institution:Division of Cardiology, Nihon University Itabashi Hospital.
Journal:Int Heart J. 2019 Jul 27;60(4):812-821. doi: 10.1536/ihj.18-517. Epub 2019 Jul 12.

10:Clinical risk factors for new-onset atrial fibrillation in acute myocardial infarction: A systematic review and meta-analysis.
Authors:He J, Yang Y, Zhang G, Lu XH
Institution:Guangdong Sanjiu Brain Hospital. Guangzhou Medical University, Guangzhou, China. Guangzhou Medical University, Guangzhou, China. Guangzhou Medical University, Guangzhou, China.
Journal:Medicine (Baltimore). 2019 Jun;98(26):e15960. doi: 10.1097/MD.0000000000015960.

11:Resting Heart Rate and the Risk of Atrial Fibrillation.
Authors:Liu X, Guo N, Zhu W, Zhou Q, Liu M, Chen C, Yuan P, Wan R, Hong K
Institution:Department of Cardiology, The Second Affiliated Hospital of Nanchang University.
Journal:Int Heart J. 2019 Jul 27;60(4):805-811. doi: 10.1536/ihj.18-470. Epub 2019 Jun 14.

12:Effectiveness of Nonvitamin K Antagonist Oral Anticoagulants and Warfarin for Preventing Further Cerebral Microbleeds in Acute Ischemic Stroke Patients with Nonvalvular Atrial Fibrillation and At Least One Microbleed: CMB-NOW Multisite Pilot Trial.
Authors:Yokoyama M, Mizuma A, Terao T, Tanaka F, Nishiyama K, Hasegawa Y, Nagata E, Nogawa S, Kobayashi H, Yanagimachi N, Okazaki T, Kitagawa K, Takizawa S
Institution:Department of Neurology, Fujisawa City Hospital, Fujiswa, Kanagawa, Japan. Japan. School of Medicine, Yokohama, Kanagawa, Japan. Kanagawa, Japan. Japan. Japan. Isehara, Tokyo, Japan. Tokyo, Japan. Tokyo, Japan. Japan. Japan. Electronic address:
Journal:J Stroke Cerebrovasc Dis. 2019 Jul;28(7):1918-1925. doi: 10.1016/j.jstrokecerebrovasdis.2019.03.050. Epub 2019 Apr 18.

13:Effect of patient education and physical training on quality of life and physical exercise capacity in patients with paroxysmal or persistent atrial fibrillation: A randomized study.
Authors:Joensen AM, Dinesen PT, Svendsen LT, Hoejbjerg TK, Fjerbaek A, Andreasen J, Sottrup MB, Lundbye-Christensen S, Vadmann H, Riahi S
Institution:Department of Clinical Medicine, Aalborg University Hospital, Aalborg, Denmark.
Journal:J Rehabil Med. 2019 Jun 18;51(6):442-450. doi: 10.2340/16501977-2551.

14:Recurrent ischemic stroke in atrial fibrillation with non-vitamin K antagonist oral anticoagulation.
Authors:Woo HG, Chung I, Gwak DS, Kim BK, Kim BJ, Bae HJ, Han MK
Institution:Department of Neurology, Ewha Womans University, College of Medicine, Seoul, Republic of Korea. Korea. Korea. Republic of Korea. National University College of Medicine, Seongnam, Republic of Korea. National University College of Medicine, Seongnam, Republic of Korea. National University College of Medicine, Seongnam, Republic of Korea. Electronic address:
Journal:J Clin Neurosci. 2019 Jun;64:127-133. doi: 10.1016/j.jocn.2019.03.037. Epub 2019 Mar 28.

15:Adequate Adherence to Direct Oral Anticoagulant is Associated with Reduced Ischemic Stroke Severity in Patients with Atrial Fibrillation.
Authors:Yamashiro K, Kurita N, Tanaka R, Ueno Y, Miyamoto N, Hira K, Nakajima S, Urabe T, Hattori N
Institution:Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan. Tochigi, Japan. Electronic address:
Journal:J Stroke Cerebrovasc Dis. 2019 Jun;28(6):1773-1780. doi: 10.1016/j.jstrokecerebrovasdis.2018.09.019. Epub 2018 Oct 12.

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