Multiple Myeloma
December 2017 Issue
 
 
 

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Multiple Myeloma abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Multiple Myeloma. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Multiple Myeloma. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Multiple Myeloma every 3 months. Thank you for your ongoing subscription to this publication.

Sincerely,
Elliot Jacob, Ph.D.
Vice-President - Content
Medifocus.com, Inc.



1:Elderly patients with multiple myeloma: towards a frailty approach?
Authors:Zweegman S, Engelhardt M, Larocca A
Institution:aDepartment of Hematology, Cancer Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands bDepartment of Medicine I, Hematology, Oncology & Stem Cell Transplantation, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany cDepartment of Hematology, University of Torino, Torino, Italy.
Journal:Curr Opin Oncol. 2017 Sep;29(5):315-321. doi: 10.1097/CCO.0000000000000395.

2:How I treat myeloma with new agents.
Authors:Moreau P
Institution:Department of Hematology, University Hospital and INSERM Unite Mixte de Recherche 892, Centre National de la Recherche Scientifique Unite Mixte de Recherche 6299, University of Nantes, Nantes, France.
Journal:Blood. 2017 Sep 28;130(13):1507-1513. doi: 10.1182/blood-2017-05-743203. Epub 2017 Jul 26.

3:How I treat first relapse of myeloma.
Authors:Harousseau JL, Attal M
Institution:Groupe Confluent, Nantes, France; and.
Journal:Blood. 2017 Aug 24;130(8):963-973. doi: 10.1182/blood-2017-03-726703. Epub 2017 Jul 5.

4:Safety of ixazomib for the treatment of multiple myeloma.
Authors:Bonnet A, Moreau P
Institution:a Department of Hematology , University Hospital Hotel-Dieu , Nantes , France.
Journal:Expert Opin Drug Saf. 2017 Aug;16(8):973-980. doi: 10.1080/14740338.2017.1344212. Epub 2017 Jul 12.

5:Melphalan hydrochloride for the treatment of multiple myeloma.
Authors:Esma F, Salvini M, Troia R, Boccadoro M, Larocca A, Pautasso C
Institution:a Myeloma Unit, Division of Hematology , Azienda Ospedaliero-Universitaria Citta della Salute e della Scienza di Torino , Torino , Italy.
Journal:Expert Opin Pharmacother. 2017 Aug;18(11):1127-1136. doi: 10.1080/14656566.2017.1349102. Epub 2017 Jul 10.

6:Current and developing synthetic pharmacotherapy for treating relapsed/refractory multiple myeloma.
Authors:Podar K, Pecherstorfer M
Institution:a Department of Internal Medicine , Karl Landsteiner University of Health Sciences, University Hospital , Krems , Austria. Sciences, University Hospital , Krems , Austria.
Journal:Expert Opin Pharmacother. 2017 Aug;18(11):1061-1079. doi: 10.1080/14656566.2017.1340942. Epub 2017 Jul 5.

7:Myeloma bone disease: pathogenesis and treatment.
Authors:O'Donnell EK, Raje NS
Institution:Harvard Medical School, Boston, Massachusetts.
Journal:Clin Adv Hematol Oncol. 2017 Apr;15(4):285-295.

8:Recent progress in relapsed multiple myeloma therapy: implications for treatment decisions.
Authors:Moreau P, de Wit E
Institution:Department of Haematology, University Hospital Hotel-Dieu, Nantes, France.
Journal:Br J Haematol. 2017 Oct;179(2):198-218. doi: 10.1111/bjh.14780. Epub 2017 May 30.

9:Increased risk of arterial thromboembolic events with combination lenalidomide/dexamethasone therapy for multiple myeloma.
Authors:Maharaj S, Chang S, Seegobin K, Serrano-Santiago I, Zuberi L
Institution:a Department of Internal Medicine , University of Florida College of Medicine , Jacksonville , FL , USA. Miami , FL , USA. Jacksonville , FL , USA. Jacksonville , FL , USA. Jacksonville , FL , USA.
Journal:Expert Rev Anticancer Ther. 2017 Jul;17(7):585-591. doi: 10.1080/14737140.2017.1330153. Epub 2017 May 23.

10:How is patient care for multiple myeloma advancing?
Authors:Genadieva Stavric S, Bonello F, Bringhen S, Boccadoro M, Larocca A
Institution:a Medical Faculty , University Hematology Clinic , Skopje , Macedonia.; b Myeloma Unit, Division of Hematology , University of Torino, Azienda Ospedaliero-Universitaria Citta della Salute e della Scienza di Torino , Torino , Italy.
Journal:Expert Rev Hematol. 2017 Jun;10(6):551-561. doi: 10.1080/17474086.2017.1326814. Epub 2017 May 19.

11:The safety of daratumumab for the treatment of multiple myeloma.
Authors:Cejalvo MJ, Ribas P, de la Rubia J
Institution:a Hematology Service , University Hospital Doctor Peset , Valencia , Spain. "San Vicente Martir" , Valencia , Spain.
Journal:Expert Opin Drug Saf. 2017 Jun;16(6):753-760. doi: 10.1080/14740338.2017.1328053. Epub 2017 May 22.

12:Novel investigational drugs active as single agents in multiple myeloma.
Authors:D'Agostino M, Salvini M, Palumbo A, Larocca A, Gay F
Institution:a Myeloma Unit, Division of Hematology , University of Torino, Azienda Ospedaliero-Universitaria Citta della Salute e della Scienza di Torino , Torino , Italy.; b Currently Takeda employee.
Journal:Expert Opin Investig Drugs. 2017 Jun;26(6):699-711. doi: 10.1080/13543784.2017.1324571. Epub 2017 May 8.

13:Daratumumab for the treatment of multiple myeloma.
Authors:Touzeau C, Moreau P
Institution:a Department of Hematology , University Hospital , Nantes , France.
Journal:Expert Opin Biol Ther. 2017 Jul;17(7):887-893. doi: 10.1080/14712598.2017.1322578. Epub 2017 May 2.

14:Immunologic approaches for the treatment of multiple myeloma.
Authors:Rasche L, Weinhold N, Morgan GJ, van Rhee F, Davies FE
Institution:Myeloma Institute, University of Arkansas for Medical Sciences, Little Rock, AR, USA. Electronic address: LRasche@uams.edu. USA. USA. USA. USA.
Journal:Cancer Treat Rev. 2017 Apr;55:190-199. doi: 10.1016/j.ctrv.2017.03.010. Epub 2017 Apr 6.

15:Efficacy and safety of bortezomib, thalidomide, and lenalidomide in multiple myeloma: An overview of systematic reviews with meta-analyses.
Authors:Aguiar PM, de Mendonca Lima T, Colleoni GWB, Storpirtis S
Institution:Department of Pharmacy, University of Sao Paulo, Sao Paulo, Brazil. Electronic address: aguiar.pm@usp.br. University of Sao Paulo, Sao Paulo, Brazil.
Journal:Crit Rev Oncol Hematol. 2017 May;113:195-212. doi: 10.1016/j.critrevonc.2017.03.014. Epub 2017 Mar 16.

16:Which therapies will move to the front line for multiple myeloma?
Authors:Cejalvo MJ, de la Rubia J
Institution:a Hematology Service , University Hospital Doctor Peset , Valencia , Spain. Martir" , Valencia , Spain.
Journal:Expert Rev Hematol. 2017 May;10(5):383-392. doi: 10.1080/17474086.2017.1317589. Epub 2017 Apr 24.

17:Current Review on High-Risk Multiple Myeloma.
Authors:Chan HSH, Chen CI, Reece DE
Institution:Princess Margaret Cancer Centre, 610 University Ave, Toronto, ON, M5G 2M9, Canada. Canada. Canada. Donna.Reece@uhn.ca.
Journal:Curr Hematol Malig Rep. 2017 Apr;12(2):96-108. doi: 10.1007/s11899-017-0368-z.

18:Therapy for Relapsed Multiple Myeloma: Guidelines From the Mayo Stratification for Myeloma and Risk-Adapted Therapy.
Authors:Dingli D, Ailawadhi S, Bergsagel PL, Buadi FK, Dispenzieri A, Fonseca R, Gertz MA, Gonsalves WI, Hayman SR, Kapoor P, Kourelis T, Kumar SK, Kyle RA, Lacy MQ, Leung N, Lin Y, Lust JA, Mikhael JR, Reeder CB, Roy V, Russell SJ, Sher T, Stewart AK, Warsame R, Zeldenrust SR, Rajkumar SV, Chanan Khan AA
Institution:Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, MN. Electronic address: dingli.david@mayo.edu. MN. MN. MN. MN. MN. MN. MN. MN. MN. MN. MN. MN. MN. MN. MN. MN. MN.
Journal:Mayo Clin Proc. 2017 Apr;92(4):578-598. doi: 10.1016/j.mayocp.2017.01.003. Epub 2017 Mar 11.

19:Allogeneic Hematopoietic Cell Transplantation for Myeloma: When and in Whom Does It Work.
Authors:Bashir Q, Qazilbash MH
Institution:Division of Cancer Medicine, Department of Stem Cell Transplantation and Cellular Therapy, UT MD Anderson Cancer Center, Houston, TX, 77030, USA. qbashir@mdanderson.org.
Journal:Curr Hematol Malig Rep. 2017 Apr;12(2):126-135. doi: 10.1007/s11899-017-0374-1.

20:How I manage the toxicities of myeloma drugs.
Authors:Delforge M, Ludwig H
Institution:Department of Hematology, University Hospital Leuven, Leuven, Belgium; and. Oncology, Haematology and Palliative Care, Wilhelminenspital, Vienna, Austria.
Journal:Blood. 2017 Apr 27;129(17):2359-2367. doi: 10.1182/blood-2017-01-725705. Epub 2017 Mar 8.

21:Immunotherapy for the treatment of multiple myeloma.
Authors:Jung SH, Lee HJ, Vo MC, Kim HJ, Lee JJ
Institution:Department of Hematology-Oncology, Chonnam National University Hwasun Hospital, Hwasun, Jeollanamdo, Republic of Korea; Research Center for Cancer Immunotherapy, Chonnam National University Hwasun Hospital, Hwasun, Jeollanamdo, Republic of Korea. Electronic address: drjejung@chonnam.ac.kr.; Department of Hematology-Oncology, Chonnam National University Hwasun Hospital, Hwasun, Jeollanamdo, Republic of Korea.
Journal:Crit Rev Oncol Hematol. 2017 Mar;111:87-93. doi: 10.1016/j.critrevonc.2017.01.011. Epub 2017 Jan 27.

22:An Evidence-Based Approach to Myeloma Bone Disease.
Authors:Bingham N, Reale A, Spencer A
Institution:Department of Haematology, Alfred Health, Melbourne, Victoria, Australia. Australia. andrew.spencer@monash.edu. Australia. andrew.spencer@monash.edu.
Journal:Curr Hematol Malig Rep. 2017 Apr;12(2):109-118. doi: 10.1007/s11899-017-0370-5.

23:Systematic Literature Review and Network Meta-Analysis of Treatment Outcomes in Relapsed and/or Refractory Multiple Myeloma.
Authors:van Beurden-Tan CHY, Franken MG, Blommestein HM, Uyl-de Groot CA, Sonneveld P
Institution:Chrissy H.Y. van Beurden-Tan and Pieter Sonneveld, Erasmus MC Cancer Institute; Margreet G. Franken, Hedwig M. Blommestein, and Carin A. Uyl-de Groot, Erasmus University Rotterdam, Rotterdam; and Hedwig M. Blommestein and Carin A. Uyl-de Groot, Comprehensive Cancer Organisation, Utrecht, the Netherlands.
Journal:J Clin Oncol. 2017 Apr 20;35(12):1312-1319. doi: 10.1200/JCO.2016.71.1663. Epub 2017 Feb 27.

24:Monoclonal antibody therapy in multiple myeloma.
Authors:Touzeau C, Moreau P, Dumontet C
Institution:Service d'hematologie clinique, Nantes, France.
Journal:Leukemia. 2017 May;31(5):1039-1047. doi: 10.1038/leu.2017.60. Epub 2017 Feb 17.

25:Modern multiple myeloma therapy: deep, sustained treatment response and good clinical outcomes.
Authors:Landgren O, Iskander K
Institution:Myeloma Service, Division of Hematology Oncology, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
Journal:J Intern Med. 2017 Apr;281(4):365-382. doi: 10.1111/joim.12590. Epub 2017 Feb 16.

26:Triplet combinations in relapsed/refractory myeloma: update on recent phase 3 trials.
Authors:Boudreault JS, Touzeau C, Moreau P
Institution:a Hematology Department , University Hospital Hotel-Dieu , Nantes , France.
Journal:Expert Rev Hematol. 2017 Mar;10(3):207-215. doi: 10.1080/17474086.2017.1285694. Epub 2017 Feb 9.

27:Emerging treatment approaches for myeloma-related bone disease.
Authors:Gavriatopoulou M, Dimopoulos MA, Kastritis E, Terpos E
Institution:a Department of Clinical Therapeutics , National and Kapodistrian University of Athens School of Medicine , Athens , Greece.
Journal:Expert Rev Hematol. 2017 Mar;10(3):217-228. doi: 10.1080/17474086.2017.1283213. Epub 2017 Jan 29.

28:Panobinostat for the management of multiple myeloma.
Authors:Sivaraj D, Green MM, Gasparetto C
Institution:Division of Hematologic Malignancies and Cellular Therapy, Duke University Medical Center, Durham, NC, USA. Medical Center, Durham, NC, USA. Medical Center, Durham, NC, USA.
Journal:Future Oncol. 2017 Mar;13(6):477-488. doi: 10.2217/fon-2016-0329. Epub 2016 Oct 25.

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