| | Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.
Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Myelodysplastic Syndromes abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Myelodysplastic Syndromes. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Myelodysplastic Syndromes. You can access the summaries of each article referenced below by simply clicking on the article Title.
We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Myelodysplastic Syndromes every 3 months. Thank you for your ongoing subscription to this publication.
Elliot Jacob, Ph.D.
Vice-President - Content
Medifocus.com, Inc.
| Authors: | Victoria K, Freedman IG |
| Institution: | University of Vermont Medical Center, Burlington, VT, U.S.A. | | Journal: | Anticancer Res. 2018 Oct;38(10):5819-5823. doi: 10.21873/anticanres.12922. |
| Authors: | Stevens BM, Khan N, D'Alessandro A, Nemkov T, Winters A, Jones CL, Zhang W, Pollyea DA, Jordan CT |
| Institution: | Division of Hematology, Department of Medicine, University of Colorado School of Medicine, Aurora, CO, 80045, USA. Medicine, Aurora, CO, 80045, USA. Aurora, CO, 80045, USA. Aurora, CO, 80045, USA. Medicine, Aurora, CO, 80045, USA. Medicine, Aurora, CO, 80045, USA. | | Journal: | Nat Commun. 2018 Sep 12;9(1):3694. doi: 10.1038/s41467-018-05984-x. |
| Authors: | Gao C, Wang J, Li Y, Zhao H, Li R, Hou L, Zhang Y, Tian S, Liang H, Wang C, Chen X, Wang J |
| Institution: | Department of Oncology and Hematology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Dongcheng District.; Cross Slope Community Health Service Station, Dongcheng District Community Health Service Management Center, Beijing, China. | | Journal: | Medicine (Baltimore). 2018 Aug;97(34):e11860. doi: 10.1097/MD.0000000000011860. |
| Authors: | Papageorgiou SG, Kontos CK, Kotsianidis I, Vasilatou D, Symeonidis A, Galanopoulos A, Bouchla A, Hatzimichael E, Repousis P, Zikos P, Viniou NA, Poulakidas E, Vassilakopoulos TP, Diamantopoulos P, Diamantopoulos MA, Mparmparousi D, Bouronikou E, Papadaki H, Panayiotidis P, Pappa V |
| Institution: | Second Department of Internal Medicine and Research Unit, University General Hospital 'Attikon', Athens, Greece.; Department of Biochemistry and Molecular Biology, University of Athens, Athens, Greece.; Department of Hematology, Democritus University of Thrace Medical School, University Hospital of Alexandroupolis, Alexandroupolis, Greece.; The Hellenic (Greek) MDS Study Group, Athens, Greece.; General University Hospital of Patras, Patras, Greece. | | Journal: | Hematol Oncol. 2018 Oct;36(4):693-700. doi: 10.1002/hon.2551. Epub 2018 Sep 7. |
| Authors: | Grignano E, Jachiet V, Fenaux P, Ades L, Fain O, Mekinian A |
| Institution: | Department of Hematology, Assistance Publique-Hopitaux de Paris, Hopital Cochin, 75014, Paris, France.; Department of Internal Medicine, Inflammation-Immunopathology-Biotherapy Department (DHU i2B), Assistance Publique - Hopitaux de Paris, Hopital Saint-Antoine, 184, rue du Faubourg Saint-Antoine, 75012, Paris, France. arsene.mekinian@aphp.fr.; UPMC University Paris 06, Paris, France. arsene.mekinian@aphp.fr.; Department of Hematology, Assistance Publique-Hopitaux de Paris, Hopital Saint Louis, 1 avenue Claude Vellefaux, 75010, Paris, France.; Sorbonne Universites, UMPC University Paris 06, INSERM U938, Centre de Recherche Saint-Antoine (CRSA), Paris, France. arsene.mekinian@aphp.fr. | | Journal: | Ann Hematol. 2018 Nov;97(11):2015-2023. doi: 10.1007/s00277-018-3472-9. Epub 2018 Aug 8. |
| Authors: | Schuler E, Zadrozny N, Blum S, Schroeder T, Strupp C, Hildebrandt B, Kundgen A, Gattermann N, Aul C, Kondakci M, Kobbe G, Haas R, Germing U |
| Institution: | Department of Hematology, Oncology and Clinical Immunology, University Hospital, Heinrich Heine-University, Moorenstr. 5, 40225, Dusseldorf, Germany. Esther.Schuler@med.uni-duesseldorf.de.; Department of Oncology, University Hospital, Lausanne, Switzerland.; Institute of Human Genetics and Anthropology, Heinrich Heine-University, Duesseldorf, Germany.; Department of Hematology and Oncology, Johannes Hospital Duisburg, Duisburg, Germany. | | Journal: | Ann Hematol. 2018 Dec;97(12):2325-2332. doi: 10.1007/s00277-018-3466-7. Epub 2018 Aug 4. |
| Authors: | Baek DW, Lee YJ, Kim H, Ahn SY, Ahn JS, Shin HJ, Lee WS, Lee SM, Song IC, Lee HS, Park SW, Choi Y, Cho YY, Bae SH, Kim HJ, Sohn SK, Moon JH |
| Institution: | Department of Hematology/Oncology, Kyungpook National University Hospital, 130 Dongdeok-ro, Jung-gu, Daegu, 41944, South Korea. Dongdeok-ro, Jung-gu, Daegu, 41944, South Korea. South Korea. Hwasun, South Korea. Hwasun, South Korea. Hwasun, South Korea. Dongdeok-ro, Jung-gu, Daegu, 41944, South Korea. Dongdeok-ro, Jung-gu, Daegu, 41944, South Korea. jhmoon@knu.ac.kr. jhmoon@knu.ac.kr. | | Journal: | Ann Hematol. 2018 Dec;97(12):2309-2317. doi: 10.1007/s00277-018-3458-7. Epub 2018 Aug 2. |
| Authors: | Sharma P, Pollyea DA |
| Institution: | Division of Hematology, University of Colorado School of Medicine, 1665 Aurora Court, Mail Stop F754, Aurora, CO, 80045, USA. daniel.pollyea@ucdenver.edu. | | Journal: | Curr Hematol Malig Rep. 2018 Aug;13(4):256-264. doi: 10.1007/s11899-018-0464-8. |
| Authors: | Kattamis A, Aydinok Y, Taher A |
| Institution: | First Department of Pediatrics, National and Kapodistrian University of Athens, Athens, Greece. Beirut, Lebanon. | | Journal: | Eur J Haematol. 2018 Sep;101(3):272-282. doi: 10.1111/ejh.13111. Epub 2018 Jul 27. |
| Authors: | Gayoso J, Balsalobre P, Kwon M, Herrera P, Bermudez A, Sampol A, Jimenez S, Lopez-Corral L, Serrano D, Pinana JL, Pascual MJ, Heras I, Bento L, Varela R, Humala K, Zabalza A, Laiglesia A, Bastos-Oreiro M, Perez-Corral A, Martinez-Laperche C, Buno I, Diez-Martin JL |
| Institution: | Facultad de Medicina Universidad Complutense, HGU Gregorio Maranon, Madrid, Spain. Spain. Spain. Spain. Spain. Spain. Spain. Spain. Spain. | | Journal: | Eur J Haematol. 2018 Sep;101(3):332-339. doi: 10.1111/ejh.13103. Epub 2018 Aug 3. |
| Authors: | Arbab Jafari P, Ayatollahi H, Sadeghi R, Sheikhi M, Asghari A |
| Institution: | a Department of Hematology and Blood Banking, Faculty of Medicine , Mashhad University of Medical Sciences , Mashhad , Iran. University of Medical Sciences , Mashhad , Iran. Medical Sciences , Mashhad , Iran. University of Medical Sciences , Mashhad , Iran. Sciences , Mashhad , Iran. | | Journal: | Hematology. 2018 Dec;23(10):778-784. doi: 10.1080/10245332.2018.1471794. Epub 2018 May 14. |
| Authors: | Toprak SK |
| Institution: | Ankara University, School of Medicine, Department of Hematology, Cebeci Hospital, Dikimevi, Ankara, Turkey. Electronic address: sktoprak@medicine.ankara.edu.tr. | | Journal: | Transfus Apher Sci. 2018 Apr;57(2):178-186. doi: 10.1016/j.transci.2018.04.018. Epub 2018 Apr 18. |
| Authors: | Shallis RM, Ahmad R, Zeidan AM |
| Institution: | Division of Hematology/Medical Oncology, Department of Medicine, Yale University School of Medicine, New Haven, CT, USA. School of Medicine, New Haven, CT, USA. School of Medicine, New Haven, CT, USA. University, New Haven, CT, USA. | | Journal: | Eur J Haematol. 2018 Sep;101(3):260-271. doi: 10.1111/ejh.13092. Epub 2018 Jul 12. |
| Authors: | Brunner AM, Steensma DP |
| Institution: | Harvard Medical School, and Center for Leukemia at Massachusetts General Hospital, Boston, Massachusetts. | | Journal: | Clin Adv Hematol Oncol. 2018 Jan;16(1):56-66. |
| Authors: | Castelli R, Schiavon R, Rossi V, Deliliers GL |
| Institution: | Department of Biomedical and Clinical Sciences Luigi Sacco, Luigi Sacco Hospital Milan, University of Milan, Milan, Italy. roberto.castelli@unimi.it. Milan, University of Milan, Milan, Italy. L. Sacco University Hospital, University of Milan, Milan, Italy. | | Journal: | Med Oncol. 2018 Apr 19;35(5):76. doi: 10.1007/s12032-018-1135-2. |
| Authors: | Arcioni F, Roncadori A, Di Battista V, Tura S, Covezzoli A, Cundari S, Mecucci C |
| Institution: | Department of Medicine, Institute of Hematology and Center for Hemato-Oncology Research (C.R.E.O.), University of Perugia, Perugia, Italy. | | Journal: | Eur J Haematol. 2018 Jul;101(1):78-85. doi: 10.1111/ejh.13067. Epub 2018 May 22. |
| Authors: | Kantarjian HM, Fenaux P, Sekeres MA, Szer J, Platzbecker U, Kuendgen A, Gaidano G, Wiktor-Jedrzejczak W, Carpenter N, Mehta B, Franklin J, Giagounidis A |
| Institution: | Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address: hkantarjian@mdanderson.org. Louis, Universite Paris 7, Paris, France. University of Melbourne, Melbourne, Australia. Medizinische Klinik und Poliklinik I, Dresden, Germany. klinische Immunologie, Heinrich-Heine-University of Dusseldorf, Medizinische Klinik und Poliklinik A, Dusseldorf, Germany. Eastern Piedmont, Novara, Italy. Dusseldorf, Germany. | | Journal: | Lancet Haematol. 2018 Mar;5(3):e117-e126. doi: 10.1016/S2352-3026(18)30016-4. Epub 2018 Jan 26. |
| Authors: | Du X, Lai YY, Xiao Z, Liu T, Hu Y, Sun A, Li X, Shen ZX, Jin J, Yu L, Laille E, Dong Q, Songer S, Beach CL |
| Institution: | Department of Hematology, Guangdong General Hospital/Guangdong Academy of Medical Sciences, Guangdong General Hospital affiliated to South China University of Technology, Guangdong, China. Beijing, China. Sciences and Peking Union Medical College, Tianjin, China. China. University of Science and Technology, Wuhan, China. Suzhou, China. College of Medicine, Zhejiang, China. | | Journal: | Asia Pac J Clin Oncol. 2018 Jun;14(3):270-278. doi: 10.1111/ajco.12835. Epub 2017 Dec 28. |
| Authors: | Mittelman M, Platzbecker U, Afanasyev B, Grosicki S, Wong RSM, Anagnostopoulos A, Brenner B, Denzlinger C, Rossi G, Nagler A, Garcia-Delgado R, Portella MSO, Zhu Z, Selleslag D |
| Institution: | Tel Aviv Sourasky Medical Center, Sackler Medical Faculty, Tel Aviv University, Tel Aviv, Israel. Electronic address: moshemt@tlvmc.gov.il. Wales Hospital, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China. | | Journal: | Lancet Haematol. 2018 Jan;5(1):e34-e43. doi: 10.1016/S2352-3026(17)30228-4. Epub 2017 Dec 11. |
| Authors: | Gattermann N |
| Institution: | Department of Hematology, Oncology and Clinical Immunology, Heinrich Heine University Dusseldorf, Dusseldorf, Germany. gattermann@med.uni-duesseldorf.de. | | Journal: | Int J Hematol. 2018 Jan;107(1):55-63. doi: 10.1007/s12185-017-2367-1. Epub 2017 Nov 25. |
| Authors: | Schroeder T, Rautenberg C, Kruger W, Platzbecker U, Bug G, Steinmann J, Klein S, Hopfer O, Nachtkamp K, Kondakci M, Geyh S, Haas R, Germing U, Bornhauser M, Kobbe G |
| Institution: | Department of Hematology, Oncology and Clinical Immunology, Medical Faculty, University of Duesseldorf, Moorenstr. 5, 40225, Dusseldorf, Germany. thomas.schroeder@med.uni-duesseldorf.de.; Clinic and Policlinic for Internal Medicine C, Hematology and Oncology, University of Greifswald, Greifswald, Germany.; Medical Clinic and Policlinic I, University Hospital Carl Gustav Carus, Dresden, Germany.; Department of Medicine II, University Hospital Frankfurt, Frankfurt am Main, Germany.; Med. Clinic III, University Medicine Mannheim, Mannheim, Germany. | | Journal: | Ann Hematol. 2018 Feb;97(2):335-342. doi: 10.1007/s00277-017-3185-5. Epub 2017 Nov 18. |
| Authors: | Wong SA, Leitch HA |
| Institution: | Faculty of Medicine, Royal College of Surgeons, Dublin, Ireland. Vancouver, Canada. Electronic address: hleitch@providencehematology.com. | | Journal: | Leuk Res. 2018 Jan;64:24-29. doi: 10.1016/j.leukres.2017.11.005. Epub 2017 Nov 11. |
| Authors: | Navada SC, Fruchtman SM, Odchimar-Reissig R, Demakos EP, Petrone ME, Zbyszewski PS, Holland JF, Silverman LR |
| Institution: | Tisch Cancer Institute, Division of Hematology/Oncology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1079, New York, NY 10029, United States. Electronic address: shyamala.navada@mssm.edu. Electronic address: sfruchtman@onconova.us. at Mount Sinai, One Gustave L. Levy Place, Box 1079, New York, NY 10029, United States. Electronic address: rosalie.odchimar-reissig@mssm.edu. at Mount Sinai, One Gustave L. Levy Place, Box 1079, New York, NY 10029, United States. Electronic address: erin.demakos@mssm.edu. Electronic address: mpetrone@onconova.us. Electronic address: pzbyszewski@onconova.us. at Mount Sinai, One Gustave L. Levy Place, Box 1079, New York, NY 10029, United States. Electronic address: james.holland@mssm.edu. at Mount Sinai, One Gustave L. Levy Place, Box 1079, New York, NY 10029, United States. Electronic address: lewis.silverman@mssm.edu. | | Journal: | Leuk Res. 2018 Jan;64:10-16. doi: 10.1016/j.leukres.2017.11.006. Epub 2017 Nov 11. |
| Authors: | Schroeder T, Rautenberg C, Haas R, Germing U, Kobbe G |
| Institution: | Department of Hematology, Oncology and Clinical Immunology, Medical Faculty, University of Duesseldorf, Moorenstr. 5, 40225, Dusseldorf, Germany. thomas.schroeder@med.uni-duesseldorf.de. | | Journal: | Int J Hematol. 2018 Feb;107(2):138-150. doi: 10.1007/s12185-017-2364-4. Epub 2017 Nov 15. |
| Authors: | Ugai T, Matsuo K, Sawada N, Iwasaki M, Yamaji T, Shimazu T, Goto A, Inoue M, Kanda Y, Tsugane S |
| Institution: | Division of Molecular and Clinical Epidemiology, Aichi Cancer Center Research Institute, Nagoya, Japan. Saitama, Japan. | | Journal: | Int J Cancer. 2018 Mar 15;142(6):1130-1138. doi: 10.1002/ijc.31135. Epub 2017 Nov 21. |
| Authors: | Heuser M, Yun H, Thol F |
| Institution: | Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany. Electronic address: heuser.michael@mh-hannover.de. Addenbrooke's Hospital, UK; Wellcome Trust-Medical Research Council, Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK. Hannover Medical School, Hannover, Germany. | | Journal: | Semin Cancer Biol. 2018 Aug;51:170-179. doi: 10.1016/j.semcancer.2017.07.009. Epub 2017 Aug 2. |
| Authors: | Fozza C |
| Institution: | Department of Clinical and Experimental Medicine, University of Sassari, Sassari, Italy. | | Journal: | Hematol Oncol. 2018 Feb;36(1):15-23. doi: 10.1002/hon.2423. Epub 2017 Apr 27. |
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