| | Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.
Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Myelodysplastic Syndromes abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Myelodysplastic Syndromes. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Myelodysplastic Syndromes. You can access the summaries of each article referenced below by simply clicking on the article Title.
We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Myelodysplastic Syndromes every 3 months. Thank you for your ongoing subscription to this publication.
Elliot Jacob, Ph.D.
Vice-President - Content
Medifocus.com, Inc.
| Authors: | Affentranger L, Bohlius J, Hallal M, Bonadies N |
| Institution: | Department of Hematology and Central Hematology Laboratory, Inselspital, Bern University Hospital, University of Bern, Switzerland. University Hospital, University of Bern, Switzerland; Department for BioMedical Research, University of Bern, Switzerland. University Hospital, University of Bern, Switzerland; Department for BioMedical Research, University of Bern, Switzerland. Electronic address: Nicolas.Bonadies@insel.ch. | | Journal: | Crit Rev Oncol Hematol. 2019 Apr;136:37-47. doi: 10.1016/j.critrevonc.2019.01.021. Epub 2019 Feb 15. |
| Authors: | Itonaga H, Ishiyama K, Aoki K, Aoki J, Ishikawa T, Uchida N, Ohashi K, Ueda Y, Fukuda T, Sakura T, Ohno Y, Iwato K, Okumura H, Kondo T, Ichinohe T, Takanashi M, Atsuta Y, Miyazaki Y |
| Institution: | Department of Hematology, Nagasaki University Hospital, 1-7-1 Sakamoto, Nagasaki, Japan. itonaga-ngs@umin.ac.jp.; Department of Hematology, Kanazawa University Hospital, Kanazawa, Japan.; Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.; Department of Hematology, Kanagawa Cancer Center, Yokohama, Japan.; Department of Hematology, Kobe City Medical Center General Hospital, Kobe, Japan. | | Journal: | Ann Hematol. 2019 Jun;98(6):1367-1381. doi: 10.1007/s00277-019-03653-7. Epub 2019 Mar 11. |
| Authors: | Hoy SM |
| Institution: | Springer, Private Bag 65901, Mairangi Bay, Auckland, 0754, New Zealand. dru@adis.com. | | Journal: | Drugs. 2019 Feb;79(2):207-213. doi: 10.1007/s40265-018-1047-7. |
| Authors: | Tang Y, Miao M, Han S, Qi J, Wang H, Ruan C, Wu D, Han Y |
| Institution: | Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China; Collaborative Innovation Center of Hematology of Soochow University, Suzhou, China; Institute of Blood and Marrow Transplantation, Suzhou, China; Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, Suzhou, China. Electronic address: wudepei@medmail.com.cn.; Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China; Collaborative Innovation Center of Hematology of Soochow University, Suzhou, China; Institute of Blood and Marrow Transplantation, Suzhou, China; Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, Suzhou, China. Electronic address: hanyue@suda.edu.cn. | | Journal: | Crit Rev Oncol Hematol. 2019 Jan;133:74-83. doi: 10.1016/j.critrevonc.2018.07.013. Epub 2018 Aug 3. |
| Authors: | Lee JH, List A, Sallman DA |
| Institution: | University of South Florida Morsani College of Medicine, Tampa, Florida. Institute, Tampa, Florida. Institute, Tampa, Florida. | | Journal: | Eur J Haematol. 2019 Mar;102(3):203-209. doi: 10.1111/ejh.13207. Epub 2019 Jan 16. |
| Authors: | Schetelig J, de Wreede LC, van Gelder M, Koster L, Finke J, Niederwieser D, Beelen D, Mufti GJ, Platzbecker U, Ganser A, Heidenreich S, Maertens J, Socie G, Brecht A, Stelljes M, Kobbe G, Volin L, Nagler A, Vitek A, Luft T, Ljungman P, Yakoub-Agha I, Robin M, Kroger N |
| Institution: | Universitaetsklinikum Dresden, Dresden, Germany. Johannes.Schetelig@uniklinikum-dresden.de. Johannes.Schetelig@uniklinikum-dresden.de. | | Journal: | Leukemia. 2019 Mar;33(3):686-695. doi: 10.1038/s41375-018-0302-y. Epub 2018 Dec 20. |
| Authors: | Weinberg OK, Hasserjian RP |
| Institution: | Department of Pathology, Boston Children's Hospital, Boston, MA, USA. Electronic address: Olga.weinberg@childrens.harvard.edu. | | Journal: | Semin Hematol. 2019 Jan;56(1):15-21. doi: 10.1053/j.seminhematol.2018.05.015. Epub 2018 Jun 23. |
| Authors: | Ko BS, Chang MC, Chiou TJ, Chang TK, Chen YC, Lin SF, Chang CS, Lu YC, Yeh SP, Chen TY, Hwang WS |
| Institution: | a Department of Internal Medicine , National Taiwan University Hospital , Taipei , Taiwan. Taiwan. General Hospital , Taipei , Taiwan. Taiwan. Taiwan. University Hospital , Kaohsiung , Taiwan. Taiwan. Tainan , Taiwan. Taichung , Taiwan. | | Journal: | Hematology. 2019 Dec;24(1):247-254. doi: 10.1080/16078454.2018.1557860. |
| Authors: | Cortes JE, Heidel FH, Hellmann A, Fiedler W, Smith BD, Robak T, Montesinos P, Pollyea DA, DesJardins P, Ottmann O, Ma WW, Shaik MN, Laird AD, Zeremski M, O'Connell A, Chan G, Heuser M |
| Institution: | Department of Leukemia, University of Texas, MD Anderson Cancer Center, Houston, TX, USA. jcortes@mdanderson.org. Gdansk, Poland. Hamburg, Germany. | | Journal: | Leukemia. 2019 Feb;33(2):379-389. doi: 10.1038/s41375-018-0312-9. Epub 2018 Dec 16. |
| Authors: | Liu Y, Bewersdorf JP, Stahl M, Zeidan AM |
| Institution: | Department of Internal Medicine, Section of Hematology, Yale University School of Medicine, New Haven, CT, USA. Medicine, New Haven, CT, USA. Cancer Center, New York, NY, USA. Medicine, New Haven, CT, USA. Electronic address: amer.zeidan@yale.edu. | | Journal: | Blood Rev. 2019 Mar;34:67-83. doi: 10.1016/j.blre.2018.12.001. Epub 2018 Dec 5. |
| Authors: | Girmenia C, Candoni A, Delia M, Latagliata R, Molteni A, Oliva EN, Palumbo GA, Poloni A, Salutari P, Santini V, Voso MT, Musto P |
| Institution: | Dipartimento di Ematologia, Oncologia e Dermatologia, Policlinico Umberto I, Sapienza University of Rome, Italy. Electronic address: girmenia@bce.uniroma1.it.; Clinica Ematologica, Centro Trapianti e Terapie Cellulari, Azienda Sanitaria Universitaria Integrata di Udine, Udine, Italy.; Hematology and BMT Unit, Policlinic of Bari, Department of Emergency and Organ Transplantation, University of Bari, Bari, Italy.; Unita Complessa di Ematologia, ASST Cremona, Cremona, Italy.; Grande Ospedale Metropolitano Bianchi Melacrino Morelli, Reggio Calabria, Italy. | | Journal: | Blood Rev. 2019 Mar;34:16-25. doi: 10.1016/j.blre.2018.10.002. Epub 2018 Oct 28. |
| Authors: | Zeidan AM, Giri S, DeVeaux M, Ballas SK, Duong VH |
| Institution: | Yale University School of Medicine and Yale Cancer Center, Smilow Cancer Hospital at Yale New Haven, New Haven, CT, USA. amer.zeidan@yale.edu. at Yale New Haven, New Haven, CT, USA. Philadelphia, PA, USA. | | Journal: | Ann Hematol. 2019 Feb;98(2):339-350. doi: 10.1007/s00277-018-3539-7. Epub 2018 Nov 9. |
| Authors: | Seguier J, Gelsi-Boyer V, Ebbo M, Hamidou Z, Charbonnier A, Bernit E, Durand JM, Harle JR, Vey N, Schleinitz N |
| Institution: | Aix-Marseille Univ, APHM, Medecine Interne Hopital de la Timone, Marseille, France. France. France. France. France. France. France. France. France. Electronic address: nicolas.schleinitz@ap-hm.fr. | | Journal: | Autoimmun Rev. 2019 Jan;18(1):36-42. doi: 10.1016/j.autrev.2018.07.009. Epub 2018 Nov 5. |
| Authors: | Alkharabsheh OA, Saadeh SS, Zblewski DL, Gangat N, Begna KH, Elliott MA, Alkhateeb HB, Patnaik MS, Hogan WJ, Litzow MR, Al-Kali A |
| Institution: | Division of Hematology, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA. alkali.aref@mayo.edu. | | Journal: | Ann Hematol. 2019 Feb;98(2):331-337. doi: 10.1007/s00277-018-3509-0. Epub 2018 Oct 18. |
| Authors: | Othus M, Sekeres MA, Nand S, Garcia-Manero G, Appelbaum FR, Erba HP, Estey E |
| Institution: | Fred Hutchinson Cancer Research Center, Seattle, WA, USA. mothus@fredhutch.org. | | Journal: | Leukemia. 2019 Feb;33(2):371-378. doi: 10.1038/s41375-018-0275-x. Epub 2018 Oct 12. |
| Authors: | Zeidan AM, Shallis RM, Wang R, Davidoff A, Ma X |
| Institution: | Section of Hematology, Division of Hematology/Medical Oncology, Department of Medicine, Yale University School of Medicine, New Haven, USA; Cancer Outcomes, Public Policy, and Effectiveness Research (COPPER) Center, Yale University, New Haven, USA. Electronic address: amer.zeidan@yale.edu. Medicine, Yale University School of Medicine, New Haven, USA. University, New Haven, USA; Department of Chronic Disease Epidemiology, School of Public Health, Yale University, New Haven, USA. University, New Haven, USA; Department of Health Policy and Management, School of Public Health, Yale University, New Haven, USA. University, New Haven, USA; Department of Chronic Disease Epidemiology, School of Public Health, Yale University, New Haven, USA. | | Journal: | Blood Rev. 2019 Mar;34:1-15. doi: 10.1016/j.blre.2018.09.001. Epub 2018 Sep 21. |
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