| | Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.
Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Myelodysplastic Syndromes abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Myelodysplastic Syndromes. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Myelodysplastic Syndromes. You can access the summaries of each article referenced below by simply clicking on the article Title.
We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Myelodysplastic Syndromes every 3 months. Thank you for your ongoing subscription to this publication.
Elliot Jacob, Ph.D.
Vice-President - Content
Medifocus.com, Inc.
| Authors: | Kadia TM, Reville PK, Borthakur G, Yilmaz M, Kornblau S, Alvarado Y, Dinardo CD, Daver N, Jain N, Pemmaraju N, Short N, Wang SA, Tidwell RSS, Islam R, Konopleva M, Garcia-Manero G, Ravandi F, Kantarjian HM |
| Institution: | Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address: tkadia@mdanderson.org. Houston, TX, USA. TX, USA. TX, USA. TX, USA. TX, USA. TX, USA. TX, USA. TX, USA. TX, USA. TX, USA. Houston, TX, USA. Houston, TX, USA. TX, USA. TX, USA. TX, USA. TX, USA. TX, USA. | | Journal: | Lancet Haematol. 2021 Aug;8(8):e552-e561. doi: 10.1016/S2352-3026(21)00192-7. |
| Authors: | Wei Y, Xiong X, Li X, Lu W, He X, Jin X, Sun R, Lyu H, Yuan T, Sun T, Zhao M |
| Institution: | The First Central Clinical College of Tianjin Medical University, Tianjin, China. Tianjin, China. | | Journal: | Cancer Sci. 2021 Sep;112(9):3636-3644. doi: 10.1111/cas.15048. Epub 2021 Jul 21. |
| Authors: | Platzbecker U, Kubasch AS, Homer-Bouthiette C, Prebet T |
| Institution: | Department of Hematology, Cellular Therapy and Hemostaseology, Leipzig University Hospital, Leipzig, Germany. Uwe.Platzbecker@medizin.uni-leipzig.de. Uwe.Platzbecker@medizin.uni-leipzig.de. Uwe.Platzbecker@medizin.uni-leipzig.de. Hospital, Leipzig, Germany. | | Journal: | Leukemia. 2021 Aug;35(8):2182-2198. doi: 10.1038/s41375-021-01265-7. Epub 2021 May 28. |
| Authors: | Stomper J, Rotondo JC, Greve G, Lübbert M |
| Institution: | Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany. Medicine, University of Freiburg, Freiburg, Germany. Medicine, University of Freiburg, Freiburg, Germany. Medicine, University of Freiburg, Freiburg, Germany. michael.luebbert@uniklinik-freiburg.de. michael.luebbert@uniklinik-freiburg.de. | | Journal: | Leukemia. 2021 Jul;35(7):1873-1889. doi: 10.1038/s41375-021-01218-0. Epub 2021 May 6. |
| Authors: | Qu WY, Zhao L, Tan XC, Zhao YH |
| Institution: | Department of Hematology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, 528 Zhangheng Road, Shanghai, 200120, China. | | Journal: | Ann Hematol. 2021 Jun;100(6):1451-1457. doi: 10.1007/s00277-021-04508-w. Epub 2021 Apr 10. |
| Authors: | Badar T, Atallah E |
| Institution: | Division of Hematology and Medical Oncology, Department of Medicine, Mayo Clinic, Jacksonville, FL, USA. of Wisconsin, USA. | | Journal: | Expert Opin Investig Drugs. 2021 Jun;30(6):665-673. doi: 10.1080/13543784.2021.1915986. Epub 2021 Apr 19. |
| Authors: | Wan Z, Han B |
| Institution: | Department of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Science, China. Medical Science, China. | | Journal: | Aging (Albany NY). 2021 Mar 26;13(8):11120-11134. doi: 10.18632/aging.202767. Epub 2021 Mar 26. |
| Authors: | Scott BL, Pasquini MC, Fei M, Fraser R, Wu J, Devine SM, Porter DL, Maziarz RT, Warlick E, Fernandez HF, Soiffer RJ, Alyea E, Hamadani M, Bashey A, Giralt S, Geller NL, Leifer E, Hourigan CS, Gui G, Mendizabal A, Horowitz MM, Deeg HJ, Horwitz ME |
| Institution: | Fred Hutchinson Cancer Research Center, Seattle, Washington. Electronic address: bscott@fhcrc.org. | | Journal: | Transplant Cell Ther. 2021 Jun;27(6):483.e1-483.e6. doi: 10.1016/j.jtct.2021.02.031. Epub 2021 Feb 26. |
| Authors: | Xu W, Ye L, Mei C, Zhou XP, Ren Y, Ma L, Ye X, Lu C, Jin J, Tong HY |
| Institution: | Department of Hematology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, PR China. Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, PR China. Hangzhou, Zhejiang, PR China. of Medicine, Hangzhou, Zhejiang Province, PR China. Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, PR China. Hangzhou, Zhejiang, PR China. of Medicine, Hangzhou, Zhejiang Province, PR China. Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, PR China. Hangzhou, Zhejiang, PR China. of Medicine, Hangzhou, Zhejiang Province, PR China. Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, PR China. Hangzhou, Zhejiang, PR China. of Medicine, Hangzhou, Zhejiang Province, PR China. Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, PR China. Hangzhou, Zhejiang, PR China. of Medicine, Hangzhou, Zhejiang Province, PR China. Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, PR China. Hangzhou, Zhejiang, PR China. of Medicine, Hangzhou, Zhejiang Province, PR China. Hangzhou, Zhejiang, PR China. Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, PR China. of Medicine, Hangzhou, Zhejiang Province, PR China. Hangzhou, Zhejiang, PR China. of Medicine, Hangzhou, Zhejiang Province, PR China. Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, PR China. Hangzhou, Zhejiang, PR China. | | Journal: | Leuk Lymphoma. 2021 Aug;62(8):1920-1929. doi: 10.1080/10428194.2021.1891230. Epub 2021 Mar 7. |
| Authors: | Liu Y, Yang C, Xue H, Ye F, Sun W, Wang J, Qi W, Niu H, Hua L, Wang H, Han B, Shao Z |
| Institution: | Department of Hematology, General Hospital, Tianjin Medical University, Tianjin, 300052, China. shaozonghong@tmu.edu.cn. | | Journal: | Int J Hematol. 2021 Jun;113(6):807-814. doi: 10.1007/s12185-021-03115-9. Epub 2021 Mar 1. |
| Authors: | Diamantopoulos PT, Viniou NA |
| Institution: | First Department of Internal Medicine, Laikon General Hospital, National and Kapodistrian University of Athens, Athens, Greece. Electronic address: pandiamantopoulos@gmail.com. | | Journal: | Leuk Res. 2021 Apr;103:106543. doi: 10.1016/j.leukres.2021.106543. Epub 2021 Feb 20. |
| Authors: | Stein EM, Bonifacio G, Latremouille-Viau D, Shi S, Guerin A, Wu EQ, Sadek I, Cao X |
| Institution: | Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Health Economics and Outcomes Research, US Oncology, Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA. | | Journal: | Leuk Lymphoma. 2021 Jun;62(6):1411-1421. doi: 10.1080/10428194.2020.1869959. Epub 2021 Jan 11. |
| Authors: | Saygin C, Carraway HE |
| Institution: | Section of Hematology/Oncology, University of Chicago, Chicago, IL 60637, USA. USA. Electronic address: carrawh@ccf.org. | | Journal: | Blood Rev. 2021 Jul;48:100791. doi: 10.1016/j.blre.2020.100791. Epub 2020 Dec 27. |
| Authors: | Abel GA, Kim HT, Hantel A, Steensma DP, Stone R, Habib A, Ho VT, Wadleigh M, El-Jawahri A, Alyea EP, DeAngelo DJ, Koreth J, Antin JH, Soiffer RJ, Cutler C |
| Institution: | Dana-Farber Cancer Institute, Boston, MA, USA. gregory_abel@dfci.harvard.edu. | | Journal: | Leukemia. 2021 Apr;35(4):1166-1175. doi: 10.1038/s41375-020-01092-2. Epub 2020 Nov 17. |
| Authors: | Schuler E, Wagner-Drouet EM, Ajib S, Bug G, Crysandt M, Dressler S, Hausmann A, Heidenreich D, Hirschbühl K, Hoepting M, Jost E, Kaivers J, Klein S, Koldehoff M, Kordelas L, Kriege O, Müller LP, Rautenberg C, Schaffrath J, Schmid C, Wolff D, Haas R, Bornhäuser M, Schroeder T, Kobbe G |
| Institution: | Department of Hematology, Oncology and Clinical Immunology, University Hospital Dusseldorf, Medical Faculty, Heinrich Heine University, Moorenstr. 5, 40225, Dusseldorf, Germany. Esther.schuler@med.uni-duesseldorf.de. | | Journal: | Ann Hematol. 2021 Apr;100(4):959-968. doi: 10.1007/s00277-020-04321-x. Epub 2020 Nov 16. |
| Authors: | Diamantopoulos PT, Symeonidis A, Pappa V, Kotsianidis I, Galanopoulos A, Pontikoglou C, Anagnostopoulos A, Vassilopoulos G, Zikos P, Hatzimichael E, Papaioannou M, Megalakaki A, Repousis P, Kotsopoulou M, Dimou M, Solomou E, Dryllis G, Tsokanas D, Papoutselis MK, Papageorgiou S, Kyrtshonis MC, Kourakli A, Papadaki H, Panayiotidis P, Viniou NA |
| Institution: | Hematology Unit, First Department of Internal Medicine, Laikon General Hospital, National and Kapodistrian University of Athens, Athens, Greece. Hospital, National and Kapodistrian University of Athens, Athens, Greece. Greece. Athens, Greece. Chortiatis, Greece. Larissa, Greece. Thessaloniki, Greece. Kapodistrian University of Athens, Athens, Greece. National and Kapodistrian University of Athens, Athens, Greece. Athens, Greece. Greece. Hospital, National and Kapodistrian University of Athens, Athens, Greece. Kapodistrian University of Athens, Athens, Greece. Kapodistrian University of Athens, Athens, Greece. National and Kapodistrian University of Athens, Athens, Greece. | | Journal: | Br J Haematol. 2021 Mar;192(6):978-987. doi: 10.1111/bjh.17062. Epub 2020 Aug 30. |
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