Polycystic Ovary Syndrome
October 2017 Issue
 
 
 

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Polycystic Ovary Syndrome abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Polycystic Ovary Syndrome. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Polycystic Ovary Syndrome. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Polycystic Ovary Syndrome every 3 months. Thank you for your ongoing subscription to this publication.

Sincerely,
Elliot Jacob, Ph.D.
Vice-President - Content
Medifocus.com, Inc.



1:Combined oral contraceptives plus spironolactone compared with metformin in women with polycystic ovary syndrome: a one-year randomized clinical trial.
Authors:Alpanes M, Alvarez-Blasco F, Fernandez-Duran E, Luque-Ramirez M, Escobar-Morreale HF
Institution:DiabetesObesity and Human Reproduction Research Group, Department of Endocrinology & Nutrition, Hospital Universitario Ramon y Cajal & Universidad de Alcala & Instituto Ramon y Cajal de Investigacion Sanitaria IRYCIS & Centro de Investigacion Biomedica en Red Diabetes y Enfermedades Metabolicas Asociadas CIBERDEM, Madrid, Spain.; DiabetesObesity and Human Reproduction Research Group, Department of Endocrinology & Nutrition, Hospital Universitario Ramon y Cajal & Universidad de Alcala & Instituto Ramon y Cajal de Investigacion Sanitaria IRYCIS & Centro de Investigacion Biomedica en Red Diabetes y Enfermedades Metabolicas Asociadas CIBERDEM, Madrid, Spain hectorfrancisco.escobar@salud.madrid.org.
Journal:Eur J Endocrinol. 2017 Nov;177(5):399-408. doi: 10.1530/EJE-17-0516.

2:Role of metformin for ovulation induction in infertile patients with polycystic ovary syndrome (PCOS): a guideline.
Authors:
Institution:American Society for Reproductive Medicine, Birmingham, Alabama.
Journal:Fertil Steril. 2017 Sep;108(3):426-441. doi: 10.1016/j.fertnstert.2017.06.026.

3:Clomiphene citrate is associated with favorable cycle characteristics but impaired outcomes of obese women with polycystic ovarian syndrome undergoing ovarian stimulation for in vitro fertilization.
Authors:Jiang S, Kuang Y
Institution:Department of Assisted Reproduction, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, People's Republic of China.
Journal:Medicine (Baltimore). 2017 Aug;96(32):e7540. doi: 10.1097/MD.0000000000007540.

4:Combined Lifestyle and Herbal Medicine in Overweight Women with Polycystic Ovary Syndrome (PCOS): A Randomized Controlled Trial.
Authors:Arentz S, Smith CA, Abbott J, Fahey P, Cheema BS, Bensoussan A
Institution:National Institute of Complementary Medicine, Western Sydney University, Building 5, Campbelltown Campus, Locked Bag 1797, Penrith, NSW, 2751, Australia.; School of Women's and Children's Health, Level 1, Women's Health Institute, Royal Hospital for Women, University of New South Wales, Barker Street, Randwick, NSW, 2031, Australia.; School of Science and Health, Western Sydney University, Building 24, Locked Bag 1797, Penrith, NSW, 2751, Australia.
Journal:Phytother Res. 2017 Sep;31(9):1330-1340. doi: 10.1002/ptr.5858. Epub 2017 Jul 7.

5:Effect of Acupuncture and Clomiphene in Chinese Women With Polycystic Ovary Syndrome: A Randomized Clinical Trial.
Authors:Wu XK, Stener-Victorin E, Kuang HY, Ma HL, Gao JS, Xie LZ, Hou LH, Hu ZX, Shao XG, Ge J, Zhang JF, Xue HY, Xu XF, Liang RN, Ma HX, Yang HW, Li WL, Huang DM, Sun Y, Hao CF, Du SM, Yang ZW, Wang X, Yan Y, Chen XH, Fu P, Ding CF, Gao YQ, Zhou ZM, Wang CC, Wu TX, Liu JP, Ng EHY, Legro RS, Zhang H
Institution:Committee of Reproductive Medicine, World Federation of Chinese Medicine Societies, Beijing, China2Department of Obstetrics and Gynecology, First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, China.; Department of Obstetrics and Gynecology, First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, China3Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.; Department of Obstetrics and Gynecology, First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, China.; Outpatient Department, Xuzhou Maternal and Children's Hospital, Xuzhou, China.; Centre for Reproductive Medicine, Dalian Maternal and Children's Centre, Dalian, China.
Journal:JAMA. 2017 Jun 27;317(24):2502-2514. doi: 10.1001/jama.2017.7217.

6:Acupuncture for polycystic ovarian syndrome: A systematic review and meta-analysis.
Authors:Jo J, Lee YJ, Lee H
Institution:aDepartment of Korean Gynecology, Conmaul Hospital of Korean Medicine bDepartment of Korean Gynecology, Jaseng Hospital of Korean Medicine cAcupuncture and Meridian Science Research Center, College of Korean Medicine, Kyung Hee University, Seoul, Korea dAustralian Research Center in Complementary and Integrative Medicine, Faculty of Health, University of Technology Sydney, Sydney, Australia.
Journal:Medicine (Baltimore). 2017 Jun;96(23):e7066. doi: 10.1097/MD.0000000000007066.

7:Gaps in knowledge among physicians regarding diagnostic criteria and management of polycystic ovary syndrome.
Authors:Dokras A, Saini S, Gibson-Helm M, Schulkin J, Cooney L, Teede H
Institution:Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address: adokras@ObGyn.upenn.edu. Philadelphia, Pennsylvania. Preventive Medicine, Monash University, Melbourne, Victoria, Australia. D.C. Philadelphia, Pennsylvania. Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
Journal:Fertil Steril. 2017 Jun;107(6):1380-1386.e1. doi: 10.1016/j.fertnstert.2017.04.011. Epub 2017 May 5.

8:Sexual function in infertile women with polycystic ovary syndrome and unexplained infertility.
Authors:Diamond MP, Legro RS, Coutifaris C, Alvero R, Robinson RD, Casson PA, Christman GM, Huang H, Hansen KR, Baker V, Usadi R, Seungdamrong A, Bates GW, Rosen RM, Schlaff W, Haisenleder D, Krawetz SA, Barnhart K, Trussell JC, Santoro N, Eisenberg E, Zhang H
Institution:Department of Obstetrics and Gynecology, Georgia Regents University, Augusta, GA; Department of Obstetrics and Gynecology, Wayne State University, Detroit, MI. Electronic address: michael.diamond@augusta.edu. PA. Medicine, Philadelphia, PA. Center at San Antonio, TX. CT. Medicine, Oklahoma City, OK. Birmingham, AL. California, San Francisco, San Francisco, CA. Reproduction, Charlottesville, VA. Medicine, Philadelphia, PA. Child Health and Human Development, Rockville, MD. CT.
Journal:Am J Obstet Gynecol. 2017 Aug;217(2):191.e1-191.e19. doi: 10.1016/j.ajog.2017.04.034. Epub 2017 Apr 26.

9:Racial and ethnic differences in the prevalence of metabolic syndrome and its components of metabolic syndrome in women with polycystic ovary syndrome: a regional cross-sectional study.
Authors:Chan JL, Kar S, Vanky E, Morin-Papunen L, Piltonen T, Puurunen J, Tapanainen JS, Maciel GAR, Hayashida SAY, Soares JM Jr, Baracat EC, Mellembakken JR, Dokras A
Institution:Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, University of Pennsylvania, Philadelphia, PA; Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Cedars-Sinai Medical Center, Los Angeles, CA.; Kar Clinic and Hospital, Orissa, India.; Department of Obstetrics and Gynecology, St Olav's Hospital, University Hospital of Trondheim, Trondheim, Norway; Institute for Laboratory Medicine, Children's and Women's Health, Norwegian University of Science and Technology, Trondheim, Norway.; Department of Obstetrics and Gynecology, University of Oulu, Oulu, Finland; PEDEGO Research Unit, University of Oulu, Oulu, Finland.; Department of Obstetrics and Gynecology, University of Oulu, Oulu, Finland.
Journal:Am J Obstet Gynecol. 2017 Aug;217(2):189.e1-189.e8. doi: 10.1016/j.ajog.2017.04.007. Epub 2017 Apr 8.

10:Polycystic ovary syndrome with hyperandrogenism as a risk factor for non-obese non-alcoholic fatty liver disease.
Authors:Kim JJ, Kim D, Yim JY, Kang JH, Han KH, Kim SM, Hwang KR, Ku SY, Suh CS, Kim SH, Choi YM
Institution:Department of Obstetrics and Gynecology, Healthcare System Gangnam Center, Seoul National University Hospital, Seoul, Korea. Seoul National University College of Medicine, Seoul, Korea.
Journal:Aliment Pharmacol Ther. 2017 Jun;45(11):1403-1412. doi: 10.1111/apt.14058. Epub 2017 Mar 30.

11:High prevalence of moderate and severe depressive and anxiety symptoms in polycystic ovary syndrome: a systematic review and meta-analysis.
Authors:Cooney LG, Lee I, Sammel MD, Dokras A
Institution:Department of Obstetrics and Gynecology, Hospital of the University of Pennsylvania, 3701 Market Street Philadelphia, PA 19104, USA.; Department of Biostatistics and Epidemiology, Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Journal:Hum Reprod. 2017 May 1;32(5):1075-1091. doi: 10.1093/humrep/dex044.

12:Metformin vs myoinositol: which is better in obese polycystic ovary syndrome patients? A randomized controlled crossover study.
Authors:Tagliaferri V, Romualdi D, Immediata V, De Cicco S, Di Florio C, Lanzone A, Guido M
Institution:Department of Obstetrics and Gynaecology, Universita Cattolica del Sacro Cuore, Roma, Italy. Roma, Italy.
Journal:Clin Endocrinol (Oxf). 2017 May;86(5):725-730. doi: 10.1111/cen.13304. Epub 2017 Feb 10.

13:Effectiveness of acupuncture in women with polycystic ovarian syndrome undergoing in vitro fertilisation or intracytoplasmic sperm injection: a systematic review and meta-analysis.
Authors:Jo J, Lee YJ
Institution:Department of Korean Gynecology, Conmaul Hospital of Korean Medicine, Seoul, Republic of Korea. Republic of Korea.
Journal:Acupunct Med. 2017 Jun;35(3):162-170. doi: 10.1136/acupmed-2016-011163. Epub 2017 Jan 11.

14:Is cardiorespiratory fitness impaired in PCOS women? A review of the literature.
Authors:Dona S, Bacchi E, Moghetti P
Institution:Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, University and AOUI of Verona, P.le Stefani, 1, 37126, Verona, Italy. paolo.moghetti@univr.it.
Journal:J Endocrinol Invest. 2017 May;40(5):463-469. doi: 10.1007/s40618-016-0599-1. Epub 2016 Dec 27.

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