Polycystic Kidney Disease
December 2017 Issue
 
 
 

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Polycystic Kidney Disease abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Polycystic Kidney Disease. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Polycystic Kidney Disease. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Polycystic Kidney Disease every 3 months. Thank you for your ongoing subscription to this publication.

Sincerely,
Elliot Jacob, Ph.D.
Vice-President - Content
Medifocus.com, Inc.



1:Tolvaptan in Later-Stage Autosomal Dominant Polycystic Kidney Disease.
Authors:Torres VE, Chapman AB, Devuyst O, Gansevoort RT, Perrone RD, Koch G, Ouyang J, McQuade RD, Blais JD, Czerwiec FS, Sergeyeva O
Institution:From the Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN (V.E.T.); the Section of Nephrology, University of Chicago, Chicago (A.B.C.); the Institute of Physiology, University of Zurich, Zurich, Switzerland (O.D.); the Division of Nephrology, Universite Catholique de Louvain Medical School, Brussels (O.D.); the Division of Nephrology, University Medical Center Groningen, Groningen, the Netherlands (R.T.G.); the Division of Nephrology, Department of Medicine, Tufts Medical Center, Boston (R.D.P.); the Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill (G.K.); and Otsuka Pharmaceutical Development and Commercialization, Rockville, MD (J.O., R.D.M., J.D.B., F.S.C., O.S.).
Journal:N Engl J Med. 2017 Nov 16;377(20):1930-1942. doi: 10.1056/NEJMoa1710030. Epub 2017 Nov 4.

2:Evidence for Bone and Mineral Metabolism Alterations in Children With Autosomal Dominant Polycystic Kidney Disease.
Authors:De Rechter S, Bacchetta J, Godefroid N, Dubourg L, Cochat P, Maquet J, Raes A, De Schepper J, Vermeersch P, Van Dyck M, Levtchenko E, D'Haese P, Evenepoel P, Mekahli D
Institution:Department of Pediatric Nephrology, University Hospitals Leuven, Leuven 3000, Belgium. Hospices Civils de Lyon, 69500 Bron, France. 1200, Belgium. Hospices Civils de Lyon, 69500 Bron, France. Hospices Civils de Lyon, 69500 Bron, France. Belgium. University Hospital, Brussels 1090, Belgium. Belgium. Belgium. Leuven, Leuven 3000, Belgium. Belgium.
Journal:J Clin Endocrinol Metab. 2017 Nov 1;102(11):4210-4217. doi: 10.1210/jc.2017-01157.

3:An Evaluation of the Safety and Efficacy of Simultaneous Bilateral Nephrectomy and Renal Transplantation for Polycystic Kidney Disease: A 20-Year Experience.
Authors:Grodstein EI, Baggett N, Wayne S, Leverson G, D'Alessandro AM, Fernandez LA, Foley DP, Mezrich JD, Odorico JS, Redfield RR 3rd, Sollinger HW, Kaufman DB
Institution:1 Division of Transplantation, Department of Surgery, University of Wisconsin School of Medicine and Public Health, University of Wisconsin, Madison, Madison, WI.
Journal:Transplantation. 2017 Nov;101(11):2774-2779. doi: 10.1097/TP.0000000000001779.

4:New treatment paradigms for ADPKD: moving towards precision medicine.
Authors:Lanktree MB, Chapman AB
Institution:Nephrology Division, Department of Medicine, McMaster University, St Joseph's Healthcare Hamilton, 50 Charlton Avenue E, Hamilton, Ontario L8N 4A6, Canada. Maryland Avenue, W503, Chicago, Illinois 60637, USA.
Journal:Nat Rev Nephrol. 2017 Dec;13(12):750-768. doi: 10.1038/nrneph.2017.127. Epub 2017 Oct 9.

5:Polycystic kidney disease among 4,436 intracranial aneurysm patients from a defined population.
Authors:Nurmonen HJ, Huttunen T, Huttunen J, Kurki MI, Helin K, Koivisto T, von Und Zu Fraunberg M, Jaaskelainen JE, Lindgren AE
Institution:From Neurosurgery (H.J.N.), School of Medicine, Institute of Clinical Medicine, Faculty of Health Sciences, University of Eastern Finland, Kuopio; Neurosurgery of NeuroCenter (T.H., J.H., K.H., T.K., M.v.u.z.F., J.E.J. A.E.L.), Kuopio University Hospital, Finland; and Broad Institute (M.I.K.), Boston, MA. antti.lindgren@kuh.fi.
Journal:Neurology. 2017 Oct 31;89(18):1852-1859. doi: 10.1212/WNL.0000000000004597. Epub 2017 Oct 4.

6:Clinicians' attitude towards family planning and timing of diagnosis in autosomal dominant polycystic kidney disease.
Authors:De Rechter S, Kringen J, Janssens P, Liebau MC, Devriendt K, Levtchenko E, Bergmann C, Jouret F, Bammens B, Borry P, Schaefer F, Mekahli D
Institution:Department of Pediatric Nephrology, University Hospital of Leuven, Leuven, Belgium. of Cologne, Cologne, Germany. Belgium. Sciences, University of Liege, Liege, Belgium. of Leuven, Leuven, Belgium. Care, University of Leuven, Leuven, Belgium. Heidelberg University Medical Centre, Heidelberg, Germany. Belgium.
Journal:PLoS One. 2017 Sep 29;12(9):e0185779. doi: 10.1371/journal.pone.0185779. eCollection 2017.

7:Polycystic kidney disease is significantly associated with dementia risk.
Authors:Yu TM, Chuang YW, Sun KT, Yu MC, Kung SC, Lee BK, Huang ST, Chen CH, Lin CL, Kao CH
Institution:From the Graduate Institute of Clinical Medical Science and School of Medicine, College of Medicine (T.-M.Y., K.-T.S., S.-T.H., C.-H.C., C.-H.K.), Pediatric Dentistry, Dental Department (K.-T.S.), and College of Medicine (C.-L.L.), China Medical University, Taichung; Division of Nephrology (T.-M.Y., Y.-W.C., S.-T.H., C.-H.C.) and Department of Medical Research and Center of Quality Management (C.-H.C.), Taichung Veterans General Hospital, Taiwan; Connie Frank Transplant Center, Division of Nephrology, Department of Medicine (S.-C.K., B.K.L.), UCSF Medical Center, San Francisco, CA; Department of Pediatrics, Division of Nephrology (M.-C.Y.), Chang Gung Memorial Hospital at Linkou, Chang Gung University, Taoyuan; Department of Life Science (C.-H.C.), Tunghai University; Management Office for Health Data (C.-L.L.) and Department of Nuclear Medicine and PET Center (C.-H.K.), China Medical University Hospital; and Department of Bioinformatics and Medical Engineering (C.-H.K.), Asia University, Taichung, Taiwan. d10040@mail.cmuh.org.tw.
Journal:Neurology. 2017 Oct 3;89(14):1457-1463. doi: 10.1212/WNL.0000000000004434. Epub 2017 Aug 30.

8:Bosutinib versus Placebo for Autosomal Dominant Polycystic Kidney Disease.
Authors:Tesar V, Ciechanowski K, Pei Y, Barash I, Shannon M, Li R, Williams JH, Levisetti M, Arkin S, Serra A
Institution:Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic; Vladimir.Tesar@vfn.cz. York. Zurich, Switzerland.
Journal:J Am Soc Nephrol. 2017 Nov;28(11):3404-3413. doi: 10.1681/ASN.2016111232. Epub 2017 Aug 24.

9:Polycystic Kidney Disease without an Apparent Family History.
Authors:Iliuta IA, Kalatharan V, Wang K, Cornec-Le Gall E, Conklin J, Pourafkari M, Ting R, Chen C, Borgo AC, He N, Song X, Heyer CM, Senum SR, Hwang YH, Paterson AD, Harris PC, Khalili K, Pei Y
Institution:Division of Nephrology and. Toronto, Toronto, Ontario, Canada. Toronto, Toronto, Ontario, Canada. Ontario, Canada. Toronto, Toronto, Ontario, Canada.
Journal:J Am Soc Nephrol. 2017 Sep;28(9):2768-2776. doi: 10.1681/ASN.2016090938. Epub 2017 May 18.

10:Biliary Tract and Liver Complications in Polycystic Kidney Disease.
Authors:Judge PK, Harper CHS, Storey BC, Haynes R, Wilcock MJ, Staplin N, Goldacre R, Baigent C, Collier J, Goldacre M, Landray MJ, Winearls CG, Herrington WG
Institution:Medical Research Council-Population Health Research Unit. Oxford, Oxford, United Kingdom; and. Service Foundation Trust, Oxford, United Kingdom. Oxford, Oxford, United Kingdom; and. Oxford, Oxford, United Kingdom; and. will.herrington@ndph.ox.ac.uk.
Journal:J Am Soc Nephrol. 2017 Sep;28(9):2738-2748. doi: 10.1681/ASN.2017010084. Epub 2017 May 2.

11:PKD2-Related Autosomal Dominant Polycystic Kidney Disease: Prevalence, Clinical Presentation, Mutation Spectrum, and Prognosis.
Authors:Cornec-Le Gall E, Audrezet MP, Renaudineau E, Hourmant M, Charasse C, Michez E, Frouget T, Vigneau C, Dantal J, Siohan P, Longuet H, Gatault P, Ecotiere L, Bridoux F, Mandart L, Hanrotel-Saliou C, Stanescu C, Depraetre P, Gie S, Massad M, Kersale A, Seret G, Augusto JF, Saliou P, Maestri S, Chen JM, Harris PC, Ferec C, Le Meur Y
Institution:Service de Nephrologie, Centre Hospitalier Regional Universitaire de Brest, Brest, France; Universite europeenne de Bretagne, Universite de Bretagne Occidentale, Brest, France; Institut National de la Sante et de la Recherche Medicale, Unite 1078, Brest, France; Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN. Electronic address: emilie.cornec-legall@chu-brest.fr.; Institut National de la Sante et de la Recherche Medicale, Unite 1078, Brest, France; Laboratoire de Genetique et Genomique Fonctionnelle et Biotechnologies, Centre Hospitalier Regional Universitaire de Brest, Brest, France.; Service de Nephrologie, Centre Hospitalier Broussais, Saint Malo, France.; Service de Nephrologie-Immunologie Clinique, Centre Hospitalier Universitaire de Nantes, Nantes, France.; Service de Nephrologie, Centre Hospitalier Yves Le Foll, Saint Brieuc, France.
Journal:Am J Kidney Dis. 2017 Oct;70(4):476-485. doi: 10.1053/j.ajkd.2017.01.046. Epub 2017 Mar 27.

12:Intracranial aneurysms in patients with autosomal dominant polycystic kidney disease: prevalence, risk of rupture, and management. A systematic review.
Authors:Cagnazzo F, Gambacciani C, Morganti R, Perrini P
Institution:Department of Neurosurgery, University of Pisa, Via Paradisa 2, 56100, Pisa, Italy. f.cagnazzo86@gmail.com. Italy. University of Pisa, Pisa, Italy. Italy.
Journal:Acta Neurochir (Wien). 2017 May;159(5):811-821. doi: 10.1007/s00701-017-3142-z. Epub 2017 Mar 10.

13:Novel treatment protocol for ameliorating refractory, chronic pain in patients with autosomal dominant polycystic kidney disease.
Authors:Casteleijn NF, van Gastel MD, Blankestijn PJ, Drenth JP, de Jager RL, Leliveld AM, Stellema R, Wolff AP, Groen GJ, Gansevoort RT
Institution:Department of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands. Groningen, Groningen, Netherlands. Utrecht, Netherlands. University of Nijmegen, Nijmegen, Netherlands. Utrecht, Netherlands. Groningen, Groningen, Netherlands. University of Groningen, Groningen, Netherlands. University of Groningen, Groningen, Netherlands. University of Groningen, Groningen, Netherlands. Groningen, Groningen, Netherlands. Electronic address: R.T.Gansevoort@umcg.nl.
Journal:Kidney Int. 2017 Apr;91(4):972-981. doi: 10.1016/j.kint.2016.12.007. Epub 2017 Jan 31.

14:An association between autosomal-dominant polycystic kidney disease and the risk of acute myocardial infarction in Asian population - results of a nationwide study.
Authors:Sung PH, Chiang HJ, Yang YH, Chen CJ, Chiang JY, Yip HK
Institution:Division of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.; Department of Obstetrics and Gynecology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.; Department for Traditional Chinese Medicine, Chang Gung Memorial Hospital, Chiayi, Taiwan.; Institute of Occupational Medicine and Industrial Hygiene, National Taiwan University College of Public Health, Taipei, Taiwan.; Center of Excellence for Chang Gung Research Datalink, Chang Gung Memorial Hospital, Chiayi, Taiwan.
Journal:Oncotarget. 2017 Mar 21;8(12):19365-19375. doi: 10.18632/oncotarget.14269.

15:Urine Osmolality, Response to Tolvaptan, and Outcome in Autosomal Dominant Polycystic Kidney Disease: Results from the TEMPO 3:4 Trial.
Authors:Devuyst O, Chapman AB, Gansevoort RT, Higashihara E, Perrone RD, Torres VE, Blais JD, Zhou W, Ouyang J, Czerwiec FS
Institution:Institute of Physiology, University of Zurich, Zurich, Switzerland; olivier.devuyst@uzh.ch. Center Groningen, University of Groningen, Groningen, The Netherlands. University School of Medicine, Boston, Massachusetts. Clinic, Rochester, Minnesota; and.
Journal:J Am Soc Nephrol. 2017 May;28(5):1592-1602. doi: 10.1681/ASN.2016040448. Epub 2016 Dec 5.

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