Polycystic Kidney Disease
April 2017 Issue
 
 
 

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Polycystic Kidney Disease abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Polycystic Kidney Disease. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Polycystic Kidney Disease. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Polycystic Kidney Disease every 3 months. Thank you for your ongoing subscription to this publication.

Sincerely,
Elliot Jacob, Ph.D.
Vice-President - Content
Medifocus.com, Inc.



1:Renal volume and cardiovascular risk assessment in normotensive autosomal dominant polycystic kidney disease patients.
Authors:Sans L, Pascual J, Radosevic A, Quintian C, Ble M, Molina L, Mojal S, Ballarin JA, Torra R, Fernandez-Llama P
Institution:aDepartment of Nephrology, Hospital del Mar, Barcelona bHospital del Mar Medical Research Institute, Barcelona cREDinREN (Red de Investigacion Renal) dDepartment of Radiology, Hospital del Mar, Barcelona eDepartment of Radiology, Fundacio Puigvert, Barcelona fDepartment of Cardiology, Hospital del Mar, Barcelona gDepartment of Statistics, Hospital del Mar Medical Research Institute, Barcelona hDepartment of Nephrology, Fundacio Puigvert, Barcelona iUniversitat Autonoma de Barcelona, Instituto de Investigacion Biomedica Sant Pau (IIB Sant Pau), Barcelona, Spain.
Journal:Medicine (Baltimore). 2016 Dec;95(49):e5595.

2:Evidence for a "Pathogenic Triumvirate" in Congenital Hepatic Fibrosis in Autosomal Recessive Polycystic Kidney Disease.
Authors:Jiang L, Fang P, Weemhoff JL, Apte U, Pritchard MT
Institution:Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160, USA. Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160, USA. Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160, USA. Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160, USA. Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160, USA.
Journal:Biomed Res Int. 2016;2016:4918798. Epub 2016 Nov 7.

3:Predictors of rapid disease progression in autosomal dominant polycystic kidney disease.
Authors:Corradi V, Gastaldon F, Caprara C, Giuliani A, Martino F, Ferrari F, Ronco C
Institution:Department of Nephrology, Dialysis and Transplantation, San Bortolo Hospital, Vicenza, Italy - valentina.corradi@ulssvicenza.it. Italy - valentina.corradi@ulssvicenza.it. Vicenza, Italy. Italy. Vicenza, Italy. Vicenza, Italy. Italy. Vicenza, Italy. Italy.
Journal:Minerva Med. 2017 Feb;108(1):43-56. doi: 10.23736/S0026-4806.16.04830-8. Epub 2016 Oct 4.

4:Combination drug versus monotherapy for the treatment of autosomal dominant polycystic kidney disease.
Authors:Rysz J, Gluba-Brzozka A, Franczyk B, Banach M, Bartnicki P
Institution:a Department of Nephrology, Hypertension and Family Medicine , Medical University of Lodz , Lodz , Poland. of Lodz , Lodz , Poland. of Lodz , Lodz , Poland. of Lodz , Lodz , Poland.
Journal:Expert Opin Pharmacother. 2016 Oct;17(15):2049-56. doi: 10.1080/14656566.2016.1232394. Epub 2016 Sep 21.

5:Hyperaldosteronism and cardiovascular risk in patients with autosomal dominant polycystic kidney disease.
Authors:Lai S, Petramala L, Mastroluca D, Petraglia E, Di Gaeta A, Indino E, Panebianco V, Ciccariello M, Shahabadi HH, Galani A, Letizia C, D'Angelo AR
Institution:aDepartment of Clinical Medicine, Sapienza University of Rome, Rome bDepartment of Internal Medicine and Medical Specialities, Sapienza University of Rome, Rome cCobellis Clinic, Tirreno SRL, Vallo della lucania, Sapri, Salerno dDepartment of Radiological, Oncological and Pathological Sciences, Sapienza University of Rome, Rome eDepartment of Clinical and Experimental Sciences, University of Brescia, Brescia fDepartment of Obstetrical-Gynecological Sciences and Urologic Sciences, Sapienza University of Rome, Rome, Italy.
Journal:Medicine (Baltimore). 2016 Jul;95(29):e4175. doi: 10.1097/MD.0000000000004175.

6:Next-generation sequencing for molecular diagnosis of autosomal recessive polycystic kidney disease.
Authors:Edrees BM, Athar M, Al-Allaf FA, Taher MM, Khan W, Bouazzaoui A, Al-Harbi N, Safar R, Al-Edressi H, Alansary K, Anazi A, Altayeb N, Ahmed MA, Abduljaleel Z
Institution:Department of Medical Genetics, Faculty of Medicine, Umm Al-Qura University, P.O. Box 715, Makkah 21955, Saudi Arabia; King Fahad Medical City, P.O. Box 59046, Riyadh 11525, Saudi Arabia. Box 715, Makkah 21955, Saudi Arabia; Science and Technology Unit, Umm Al -Qura University, P.O. Box 715, Makkah 21955, Saudi Arabia. Electronic address: athar80@gmail.com. Box 715, Makkah 21955, Saudi Arabia; Science and Technology Unit, Umm Al -Qura University, P.O. Box 715, Makkah 21955, Saudi Arabia; Molecular Diagnostics Unit, Department of Laboratory and Blood Bank, King Abdullah Medical City, Makkah 21955, Saudi Arabia. Electronic address: faallaf@uqu.edu.sa. Box 715, Makkah 21955, Saudi Arabia; Science and Technology Unit, Umm Al -Qura University, P.O. Box 715, Makkah 21955, Saudi Arabia. Saud Bin Abdulaziz University for Health Sciences, PO, Box 3660, Riyadh 11426, Saudi Arabia. Box 715, Makkah 21955, Saudi Arabia; Science and Technology Unit, Umm Al -Qura University, P.O. Box 715, Makkah 21955, Saudi Arabia. P.O. Box 40047, Jeddah 21499, Saudi Arabia. Arabia. Arabia. Box 715, Makkah 21955, Saudi Arabia; Science and Technology Unit, Umm Al -Qura University, P.O. Box 715, Makkah 21955, Saudi Arabia. Electronic address: zainulbio@gmail.com.
Journal:Gene. 2016 Oct 10;591(1):214-26. doi: 10.1016/j.gene.2016.07.021. Epub 2016 Jul 9.

7:The Risk for New-Onset Diabetes Mellitus after Kidney Transplantation in Patients with Autosomal Dominant Polycystic Kidney Disease: A Systematic Review and Meta-Analysis.
Authors:Cheungpasitporn W, Thongprayoon C, Vijayvargiya P, Anthanont P, Erickson SB
Institution:Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, United States. Electronic address: wcheungpasitporn@gmail.com. United States. States. Faculty of Medicine, Thammasat University Hospital, Bangkok, Thailand. United States.
Journal:Can J Diabetes. 2016 Dec;40(6):521-528. doi: 10.1016/j.jcjd.2016.03.001. Epub 2016 May 13.

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