Polycystic Kidney Disease
June 2018 Issue

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Polycystic Kidney Disease abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Polycystic Kidney Disease. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Polycystic Kidney Disease. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Polycystic Kidney Disease every 3 months. Thank you for your ongoing subscription to this publication.

Elliot Jacob, Ph.D.
Vice-President - Content
Medifocus.com, Inc.

1:Tolvaptan in Later-Stage Autosomal Dominant Polycystic Kidney Disease.
Authors:Torres VE, Chapman AB, Devuyst O, Gansevoort RT, Perrone RD, Koch G, Ouyang J, McQuade RD, Blais JD, Czerwiec FS, Sergeyeva O
Institution:From the Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN (V.E.T.); the Section of Nephrology, University of Chicago, Chicago (A.B.C.); the Institute of Physiology, University of Zurich, Zurich, Switzerland (O.D.); the Division of Nephrology, Universite Catholique de Louvain Medical School, Brussels (O.D.); the Division of Nephrology, University Medical Center Groningen, Groningen, the Netherlands (R.T.G.); the Division of Nephrology, Department of Medicine, Tufts Medical Center, Boston (R.D.P.); the Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill (G.K.); and Otsuka Pharmaceutical Development and Commercialization, Rockville, MD (J.O., R.D.M., J.D.B., F.S.C., O.S.).
Journal:N Engl J Med. 2017 Nov 16;377(20):1930-1942. doi: 10.1056/NEJMoa1710030. Epub 2017 Nov 4.

2:New treatment paradigms for ADPKD: moving towards precision medicine.
Authors:Lanktree MB, Chapman AB
Institution:Nephrology Division, Department of Medicine, McMaster University, St Joseph's Healthcare Hamilton, 50 Charlton Avenue E, Hamilton, Ontario L8N 4A6, Canada. Maryland Avenue, W503, Chicago, Illinois 60637, USA.
Journal:Nat Rev Nephrol. 2017 Dec;13(12):750-768. doi: 10.1038/nrneph.2017.127. Epub 2017 Oct 9.

3:Bosutinib versus Placebo for Autosomal Dominant Polycystic Kidney Disease.
Authors:Tesar V, Ciechanowski K, Pei Y, Barash I, Shannon M, Li R, Williams JH, Levisetti M, Arkin S, Serra A
Institution:Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic; Vladimir.Tesar@vfn.cz. York. Zurich, Switzerland.
Journal:J Am Soc Nephrol. 2017 Nov;28(11):3404-3413. doi: 10.1681/ASN.2016111232. Epub 2017 Aug 24.

4:Image texture features predict renal function decline in patients with autosomal dominant polycystic kidney disease.
Authors:Kline TL, Korfiatis P, Edwards ME, Bae KT, Yu A, Chapman AB, Mrug M, Grantham JJ, Landsittel D, Bennett WM, King BF, Harris PC, Torres VE, Erickson BJ
Institution:Department of Radiology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA. USA. Rochester, Minnesota, USA. Center, Kansas City, Kansas, USA. Medical Center, Birmingham, Alabama, USA. Center, Kansas City, Kansas, USA. USA. USA. Rochester, Minnesota, USA. Rochester, Minnesota, USA. USA. Electronic address: bje@mayo.edu.
Journal:Kidney Int. 2017 Nov;92(5):1206-1216. doi: 10.1016/j.kint.2017.03.026. Epub 2017 May 20.

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