Parkinson's Disease
March 2021 Issue

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Parkinson's Disease abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Parkinson's Disease. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Parkinson's Disease. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Parkinson's Disease every 3 months. Thank you for your ongoing subscription to this publication.

Elliot Jacob, Ph.D.
Vice-President - Content, Inc.

1:No impact of confinement during COVID-19 pandemic on anxiety and depression in Parkinsonian patients.
Authors:El Otmani H, El Bidaoui Z, Amzil R, Bellakhdar S, El Moutawakil B, Abdoh Rafai M
Institution:Neurology Department, Ibn Rochd Hospital, Casablanca, Morocco; Genetics and Molecular Biology Laboratory; Faculty of Medicine and Pharmacy, Hassan II University, Casablanca, Morocco. Electronic address: Neurology Department, Ibn Rochd Hospital, Casablanca, Morocco; Faculty of Medicine and Pharmacy, Hassan II University, Casablanca, Morocco.
Journal:Rev Neurol (Paris). 2021 Mar;177(3):272-274. doi: 10.1016/j.neurol.2021.01.005. Epub 2021 Feb 11.

2:COVID-19 Vaccination for Persons with Parkinson's Disease: Light at the End of the Tunnel?
Authors:Bloem BR, Trenkwalder C, Sanchez-Ferro A, Kalia LV, Alcalay R, Chiang HL, Kang UJ, Goetz C, Brundin P, Papa SM
Institution:Radboud University Nijmegen Medical Center, Donders Institute for Brain, Cognition and Behavior, Department of Neurology, Nijmegen, the Netherlands. Yerkes National Primate Research Center, Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA.
Journal:J Parkinsons Dis. 2021;11(1):3-8. doi: 10.3233/JPD-212573.

3:Parkinson Disease.
Authors:Halli-Tierney AD, Luker J, Carroll DG
Institution:University of Alabama, Tuscaloosa, AL, USA. Auburn University Harrison School of Pharmacy, Auburn, AL, USA.
Journal:Am Fam Physician. 2020 Dec 1;102(11):679-691.

4:Risk of Hospitalization and Death for COVID-19 in People with Parkinson's Disease or Parkinsonism.
Authors:Vignatelli L, Zenesini C, Belotti LMB, Baldin E, Bonavina G, Calandra-Buonaura G, Cortelli P, Descovich C, Fabbri G, Giannini G, Guarino M, Pantieri R, Samoggia G, Scaglione C, Trombetti S, D'Alessandro R, Nonino F
Institution:IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy.
Journal:Mov Disord. 2021 Jan;36(1):1-10. doi: 10.1002/mds.28408. Epub 2020 Dec 2.

5:Intrajejunal vs oral levodopa-carbidopa therapy in Parkinson disease: A retrospective cohort study.
Authors:Popa LC, Leucuta DC, Tohanean N, Popa SL, Perju-Dumbrava L
Institution:Neurology Department.
Journal:Medicine (Baltimore). 2020 Nov 13;99(46):e23249. doi: 10.1097/MD.0000000000023249.

6:Is COVID-19 a Perfect Storm for Parkinson's Disease?
Authors:Brundin P, Nath A, Beckham JD
Institution:Center for Neurodegenerative Science, Van Andel Institute, Grand Rapids, MI, USA. Electronic address: Division of Medicine, Neurology and Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Journal:Trends Neurosci. 2020 Dec;43(12):931-933. doi: 10.1016/j.tins.2020.10.009. Epub 2020 Oct 21.

7:Anxiety: An ignored aspect of Parkinson's disease lacking attention.
Authors:Khatri DK, Choudhary M, Sood A, Singh SB
Institution:Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, 500037, India. Electronic address:
Journal:Biomed Pharmacother. 2020 Nov;131:110776. doi: 10.1016/j.biopha.2020.110776. Epub 2020 Oct 3.

8:Dilemma in Parkinson's Treatment; Levodopa Monotherapy May be the Best Choice.
Authors:Abbasi MH, Esmaeili S, Habibi SA, Shahidi GA
Institution:Department of Neurology, Iran University of Medical Sciences, Tehran, Iran; Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran; Student Research Committee, Iran University of Medical Sciences, Tehran, Iran. Department of Neurology, Iran University of Medical Sciences, Tehran, Iran. Electronic address:
Journal:J Clin Neurosci. 2020 Sep;79:219-223. doi: 10.1016/j.jocn.2020.06.024. Epub 2020 Aug 6.

9:Probiotics for Constipation in Parkinson Disease: A Randomized Placebo-Controlled Study.
Authors:Tan AH, Lim SY, Chong KK, A Manap MAA, Hor JW, Lim JL, Low SC, Chong CW, Mahadeva S, Lang AE
Institution:From the Division of Neurology (A.H.T., S.-Y.L., K.K.C., M.A.A.A.M., J.W.H., J.L.L., S.C.L.), Department of Medicine, and the Mah Pooi Soo & Tan Chin Nam Centre for Parkinson's & Related Disorders (A.H.T., S.-Y.L., K.K.C., M.A.A.A.M., J.W.H., J.L.L., S.C.L.), Faculty of Medicine, University of Malaya, Kuala Lumpur; School of Pharmacy (C.W.C.), Monash University Malaysia, Selangor; Division of Gastroenterology (S.M.), Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia; and Edmond J. Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Clinic (A.E.L.), Toronto Western Hospital, Toronto, Canada From the Division of Neurology (A.H.T., S.-Y.L., K.K.C., M.A.A.A.M., J.W.H., J.L.L., S.C.L.), Department of Medicine, and the Mah Pooi Soo & Tan Chin Nam Centre for Parkinson's & Related Disorders (A.H.T., S.-Y.L., K.K.C., M.A.A.A.M., J.W.H., J.L.L., S.C.L.), Faculty of Medicine, University of Malaya, Kuala Lumpur; School of Pharmacy (C.W.C.), Monash University Malaysia, Selangor; Division of Gastroenterology (S.M.), Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia; and Edmond J. Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Clinic (A.E.L.), Toronto Western Hospital, Toronto, Canada.
Journal:Neurology. 2021 Feb 2;96(5):e772-e782. doi: 10.1212/WNL.0000000000010998. Epub 2020 Oct 12.

10:A systematic review of active group-based dance, singing, music therapy and theatrical interventions for quality of life, functional communication, speech, motor function and cognitive status in people with Parkinson's disease.
Authors:Barnish MS, Barran SM
Institution:Peninsula Technology Assessment Group (PenTAG), Institute of Health Research, University of Exeter Medical School, Exeter, UK. Children and Young People's Speech and Language Therapy, Evelina London Community Children's Services, Mary Sheridan Health Centre, Guy's and St Thomas' NHS Foundation Trust, London, UK.
Journal:BMC Neurol. 2020 Oct 10;20(1):371. doi: 10.1186/s12883-020-01938-3.

11:Common Myths and Misconceptions That Sidetrack Parkinson Disease Treatment, to the Detriment of Patients.
Authors:Ahlskog JE
Institution:Department of Neurology, Mayo Clinic, Rochester, MN. Electronic address:
Journal:Mayo Clin Proc. 2020 Oct;95(10):2225-2234. doi: 10.1016/j.mayocp.2020.02.006.

12:Co-occurrence of apathy and impulse control disorders in Parkinson disease.
Authors:Scott BM, Eisinger RS, Burns MR, Lopes J, Okun MS, Gunduz A, Bowers D
Institution:From the Department of Clinical and Health Psychology (B.M.S., D.B.), Departments of Neuroscience (R.S.E., A.G.) and Neurology (M.R.B., J.L., M.S.O.), Norman Fixel Institute of Neurological Diseases, and J. Crayton Pruitt Department of Biomedical Engineering (A.G.), University of Florida, Gainesville.
Journal:Neurology. 2020 Nov 17;95(20):e2769-e2780. doi: 10.1212/WNL.0000000000010965. Epub 2020 Oct 1.

13:Investigation on sleep and mental health of patients with Parkinson's disease during the Coronavirus disease 2019 pandemic.
Authors:Xia Y, Kou L, Zhang G, Han C, Hu J, Wan F, Yin S, Sun Y, Wu J, Li Y, Zhang Z, Huang J, Xiong N, Wang T
Institution:Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address:
Journal:Sleep Med. 2020 Nov;75:428-433. doi: 10.1016/j.sleep.2020.09.011. Epub 2020 Sep 10.

14:Cardiovascular Risk Among Patients ≥65 Years of Age with Parkinson's Disease (From the National Inpatient Sample).
Authors:Abugroun A, Taha A, Abdel-Rahman M, Patel P, Ali I, Klein LW
Institution:Department of Medicine, Medical College of Wisconsin (MCW), 8701 W Watertown Plank Rd, Wauwatosa, Wisconsin 53226. Electronic address: Division of Cardiology, University of California, San Francisco, California.
Journal:Am J Cardiol. 2020 Dec 1;136:56-61. doi: 10.1016/j.amjcard.2020.09.021. Epub 2020 Sep 15.

15:Impact of home confinement during COVID-19 pandemic on Parkinson's disease.
Authors:Kumar N, Gupta R, Kumar H, Mehta S, Rajan R, Kumar D, Kandadai RM, Desai S, Wadia P, Basu P, Mondal B, Sanchita, Rawat A, Meka SS, Mishal B, Prashanth LK, Srivastava AK, Goyal V
Institution:Department of Neurology, All India Institute of Medical Sciences, Rishikesh, India. Electronic address: Department of Neurology, Medanta Hospital, Gurugram, India.
Journal:Parkinsonism Relat Disord. 2020 Nov;80:32-34. doi: 10.1016/j.parkreldis.2020.09.003. Epub 2020 Sep 6.

16:Effect of Subthalamic Nucleus Deep Brain Stimulation (STN-DBS) on balance performance in Parkinson's disease.
Authors:Li H, Liang S, Yu Y, Wang Y, Cheng Y, Yang H, Tong X
Institution:Department of Neurosurgery, Tianjin Huanhu Hosptial, Tianjin, China.
Journal:PLoS One. 2020 Sep 11;15(9):e0238936. doi: 10.1371/journal.pone.0238936. eCollection 2020.

17:The Six-item Clock-Drawing Scoring System: a rapid screening for cognitive impairment in Parkinson's disease.
Authors:Lolekha P, Tangkanakul C, Saengchatri T, Kulkeartprasert P
Institution:Neurology Division, Department of Internal Medicine, Faculty of Medicine, Thammasat University, Pathumthani, Thailand.
Journal:Psychogeriatrics. 2021 Jan;21(1):24-31. doi: 10.1111/psyg.12605. Epub 2020 Sep 1.

18:Safety considerations when using non-ergot dopamine agonists to treat Parkinson's disease.
Authors:Stocchi F, Fossati B, Torti M
Institution:Neurology, Institute for Research and Medical Care IRCCS San Raffaele Pisana , Rome, Italy.
Journal:Expert Opin Drug Saf. 2020 Sep;19(9):1155-1172. doi: 10.1080/14740338.2020.1804550. Epub 2020 Oct 3.

19:Interventions Involving Biofeedback to Improve Swallowing in People With Parkinson Disease and Dysphagia: A Systematic Review.
Authors:Battel I, Calvo I, Walshe M
Institution:Department of Clinical Speech & Language Studies, University of Dublin, Trinity College Dublin, Dublin, Republic of Ireland. Electronic address:
Journal:Arch Phys Med Rehabil. 2021 Feb;102(2):314-322. doi: 10.1016/j.apmr.2020.06.033. Epub 2020 Aug 27.

20:Therapeutic strategies for Parkinson's disease: promising agents in early clinical development.
Authors:Fabbri M, Perez-Lloret S, Rascol O
Institution:Clinical Investigation Center CIC1436, Department of Clinical Pharmacology and Neurosciences, Parkinson Expert Centre and NeuroToul Center of Excellence in Neurodegeneration (COEN) of Toulouse; INSERM, University of Toulouse 3, CHU of Toulouse , Toulouse, France.
Journal:Expert Opin Investig Drugs. 2020 Nov;29(11):1249-1267. doi: 10.1080/13543784.2020.1814252. Epub 2020 Sep 2.

21:Depressive symptoms are associated with worse cognitive prognosis in patients with newly diagnosed idiopathic Parkinson disease.
Authors:Park JH, Lee SH, Kim Y, Park SW, Byeon GH, Jang JW
Institution:Department of Neurology, Kangwon National University Hospital, Kangwon National University College of Medicine, Chuncheon, South Korea.
Journal:Psychogeriatrics. 2020 Nov;20(6):880-890. doi: 10.1111/psyg.12601. Epub 2020 Aug 24.

22:Fixed-dose combination therapy for Parkinson's disease with a spotlight on entacapone in the past 20 years: a reduced pill burden and a simplified dosing regime.
Authors:Salamon A, Zádori D, Szpisjak L, Klivényi P, Vécsei L
Institution:Department of Neurology, Faculty of Medicine, Albert Szent-Gyorgyi Clinical Center, University of Szeged , Szeged, Hungary.
Journal:Expert Opin Pharmacother. 2020 Dec;21(18):2265-2278. doi: 10.1080/14656566.2020.1806237. Epub 2020 Aug 18.

23:An update on the use of non-ergot dopamine agonists for the treatment of Parkinson's disease.
Authors:Cerri S, Blandini F
Institution:Laboratory of Cellular and Molecular Neurobiology, IRCCS Mondino Foundation , Pavia, Italy.
Journal:Expert Opin Pharmacother. 2020 Dec;21(18):2279-2291. doi: 10.1080/14656566.2020.1805432. Epub 2020 Aug 17.

24:Non-Motor Symptoms in Parkinson's Disease are Reduced by Nabilone.
Authors:Peball M, Krismer F, Knaus HG, Djamshidian A, Werkmann M, Carbone F, Ellmerer P, Heim B, Marini K, Valent D, Goebel G, Ulmer H, Stockner H, Wenning GK, Stolz R, Krejcy K, Poewe W, Seppi K
Institution:Department of Neurology, Innsbruck Medical University, Innsbruck, Austria.
Journal:Ann Neurol. 2020 Oct;88(4):712-722. doi: 10.1002/ana.25864. Epub 2020 Aug 31.

25:Telemedicine in Parkinson's Disease: How to Ensure Patient Needs and Continuity of Care at the Time of COVID-19 Pandemic.
Authors:Miele G, Straccia G, Moccia M, Leocani L, Tedeschi G, Bonavita S, Lavorgna L
Institution:Department of Advanced Medical and Surgical Sciences, II Clinic of Neurology, University of Campania 'Luigi Vanvitelli,' Naples, Italy. Department of Advanced Medical and Surgical Sciences, University of Campania 'Luigi Vanvitelli,' Naples, Italy.
Journal:Telemed J E Health. 2020 Dec;26(12):1533-1536. doi: 10.1089/tmj.2020.0184. Epub 2020 Jul 13.

26:Sexual Dysfunction in Parkinson Disease: A Multicenter Italian Cross-sectional Study on a Still Overlooked Problem.
Authors:Raciti L, De Cola MC, Ortelli P, Corallo F, Lo Buono V, Morini E, Quattrini F, Filoni S, Calabrò RS
Institution:IRCCS Centro Neurolesi 'Bonino-Pulejo', Messina, Italy. Electronic address:
Journal:J Sex Med. 2020 Oct;17(10):1914-1925. doi: 10.1016/j.jsxm.2020.06.010. Epub 2020 Jul 11.

27:Dopamine-responsive and dopamine-resistant resting tremor in Parkinson disease.
Authors:Zach H, Dirkx MF, Roth D, Pasman JW, Bloem BR, Helmich RC
Institution:From the Department of Neurology (H.Z., M.F.D., J.W.P., B.R.B., R.C.H.), Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, the Netherlands; and Departments of Neurology (H.Z.) and Emergency Medicine (D.R.), Medical University Vienna, Austria.
Journal:Neurology. 2020 Sep 15;95(11):e1461-e1470. doi: 10.1212/WNL.0000000000010316. Epub 2020 Jul 10.

28:An evaluation of subcutaneous apomorphine for the treatment of Parkinson's disease.
Authors:Müller T
Institution:Department of Neurology, St. Joseph Hospital Berlin-Weiensee , Berlin, Germany.
Journal:Expert Opin Pharmacother. 2020 Oct;21(14):1659-1665. doi: 10.1080/14656566.2020.1787379. Epub 2020 Jul 8.

29:Guidelines on exercise testing and prescription for patients at different stages of Parkinson's disease.
Authors:Martignon C, Pedrinolla A, Ruzzante F, Giuriato G, Laginestra FG, Bouça-Machado R, Ferreira JJ, Tinazzi M, Schena F, Venturelli M
Institution:Department of Life Sciences, University of Trieste, Trieste, Italy. Department of Neuroscience, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.
Journal:Aging Clin Exp Res. 2021 Feb;33(2):221-246. doi: 10.1007/s40520-020-01612-1. Epub 2020 Jun 8.

30:Subthalamic nucleus deep brain stimulation for Parkinson's disease: current trends and future directions.
Authors:Macerollo A, Zrinzo L, Akram H, Foltynie T, Limousin P
Institution:Department of Neurology, The Walton Centre NHS Foundation Trust , Liverpool, UK. Unit of Functional Neurosurgery, National Hospital for Neurology and Neurosurgery , London, UK.
Journal:Expert Rev Med Devices. 2020 Oct;17(10):1063-1074. doi: 10.1080/17434440.2020.1747433. Epub 2020 Apr 6.

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