Parkinson's Disease
November 2019 Issue

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Parkinson's Disease abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Parkinson's Disease. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Parkinson's Disease. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Parkinson's Disease every 3 months. Thank you for your ongoing subscription to this publication.

Elliot Jacob, Ph.D.
Vice-President - Content, Inc.

1:Approach to Assessment of Parkinson Disease with Emphasis on Genetic Testing.
Authors:Payne K, Walls B, Wojcieszek J
Institution:Department of Neurology, Indiana University School of Medicine, 355 West 16th Street, Suite 4700, Indianapolis, IN 46202, USA. Electronic address:
Journal:Med Clin North Am. 2019 Nov;103(6):1055-1075. doi: 10.1016/j.mcna.2019.08.003. Epub 2019 Aug 31.

2:A new therapeutic strategy with istradefylline for postural deformities in Parkinson's disease.
Authors:Fujioka S, Yoshida R, Nose K, Hayashi Y, Mishima T, Fukae J, Kitano K, Kikuchi H, Tsuboi Y
Institution:Department of Neurology, Murakami Karindoh Hospital, Fukuoka, Japan.
Journal:Neurol Neurochir Pol. 2019;53(4):291-295. doi: 10.5603/PJNNS.a2019.0036. Epub 2019 Aug 23.

3:ParkProTrain: an individualized, tablet-based physiotherapy training programme aimed at improving quality of life and participation restrictions in PD patients - a study protocol for a quasi-randomized, longitudinal and sequential multi-method study.
Authors:Siegert C, Hauptmann B, Jochems N, Schrader A, Deck R
Institution:Department Rehabilitation Sciences, Institute for Social Medicine and Epidemiology, University of Lubeck, Ratzeburger Allee 160, 23562, Lubeck, Germany. Hamburg, Germany. Germany. Germany.
Journal:BMC Neurol. 2019 Jun 25;19(1):143. doi: 10.1186/s12883-019-1355-x.

4:L-3-n-butylphthalide soft capsules in the treatment of Parkinson disease dementia: A systematic review and meta-analysis of randomized controlled trials.
Authors:Zhong R, Chen Q, Zhang X, Li M, Lin W
Institution:Department of Neurology. Lin Province, China.
Journal:Medicine (Baltimore). 2019 Jun;98(24):e16082. doi: 10.1097/MD.0000000000016082.

5:Recent Developments in LRRK2-Targeted Therapy for Parkinson's Disease.
Authors:Zhao Y, Dzamko N
Institution:Brain and Mind Centre, Central Clinical School, University of Sydney, Camperdown, NSW, 2050, Australia.
Journal:Drugs. 2019 Jul;79(10):1037-1051. doi: 10.1007/s40265-019-01139-4.

6:Changing the treatment paradigm for Parkinson's disease psychosis with pimavanserin.
Authors:Lyons KE, Pahwa R, Hermanowicz N, Davis T, Pagan F, Isaacson S
Institution:a Department of Neurology , University of Kansas Medical Center , Kansas City , KS , USA. KS , USA. , USA. DC , USA. FL , USA.
Journal:Expert Rev Clin Pharmacol. 2019 Jul;12(7):681-691. doi: 10.1080/17512433.2019.1623669. Epub 2019 Jun 13.

7:Drug treatment strategies for depression in Parkinson disease.
Authors:Ryan M, Eatmon CV, Slevin JT
Institution:a Department of Pharmacy Practice and Science , University of Kentucky College of Pharmacy , Lexington , KY , USA. Healthcare System , Lexington , KY , USA. of Kentucky College of Medicine , Lexington , KY , USA.
Journal:Expert Opin Pharmacother. 2019 Aug;20(11):1351-1363. doi: 10.1080/14656566.2019.1612877. Epub 2019 May 23.

8:Treatment of Neurodegenerative Diseases with Bioactive Components of Tripterygium wilfordii.
Authors:Li J, Hao J
Institution:* School of Pharmacy, Key laboratory of Pharmaceutical Quality Control of Hebei Province, Hebei University, Baoding, Hebei, P. R. China. Pomona, CA 91766, USA. Health Sciences, Pomona, CA 91766, USA.
Journal:Am J Chin Med. 2019;47(4):769-785. doi: 10.1142/S0192415X1950040X. Epub 2019 May 15.

9:Deep brain stimulation in parkinson disease.
Authors:Bernardo WM, Rubira C, Silvinato A
Institution:Brazilian Medical Association, Rua Sao Carlos do Pinhal, 324 - Bela Vista, Sao Paulo - SP, Brasil. Paulo - SP, Brasil. Paulo - SP, Brasil.
Journal:Rev Assoc Med Bras (1992). 2019 May 2;65(4):541-546. doi: 10.1590/1806-9282.65.4.541.

10:Mesenchymal Stromal Cell Therapies for Neurodegenerative Diseases.
Authors:Staff NP, Jones DT, Singer W
Institution:Department of Neurology, Mayo Clinic, Rochester, MN. Electronic address:
Journal:Mayo Clin Proc. 2019 May;94(5):892-905. doi: 10.1016/j.mayocp.2019.01.001.

11:Efficacy of istradefylline for gait disorders with freezing of gait in Parkinson's disease: A single-arm, open-label, prospective, multicenter study.
Authors:Iijima M, Orimo S, Terashi H, Suzuki M, Hayashi A, Shimura H, Mitoma H, Kitagawa K, Okuma Y
Institution:a Department of Neurology , Tokyo Women's Medical University , Tokyo , Japan. School of Medicine , Tokyo , Japan. Japan. Japan. Japan.
Journal:Expert Opin Pharmacother. 2019 Aug;20(11):1405-1411. doi: 10.1080/14656566.2019.1614167. Epub 2019 May 28.

12:Long-term effect of levodopa-carbidopa intestinal gel on axial signs in Parkinson's disease.
Authors:Fabbri M, Pongmala C, Artusi CA, Romagnolo A, Rizzone MG, Zibetti M, Lopiano L
Institution:Department of Neuroscience "Rita Levi Montalcini", University of Torino, Turin, Italy. Lisbon, Portugal. Italy.
Journal:Acta Neurol Scand. 2019 Aug;140(2):157-161. doi: 10.1111/ane.13110. Epub 2019 May 13.

13:Parkinson's disease: Mechanisms, translational models and management strategies.
Authors:Raza C, Anjum R, Shakeel NUA
Institution:Department of Zoology, Government College University, Lahore 54000, Pakistan. Electronic address:
Journal:Life Sci. 2019 Jun 1;226:77-90. doi: 10.1016/j.lfs.2019.03.057. Epub 2019 Apr 10.

14:Motor fluctuations and psychological distress in Parkinson's disease.
Authors:Fernie BA, Spada MM, Brown RG
Institution:Department of Psychology.
Journal:Health Psychol. 2019 Jun;38(6):518-526. doi: 10.1037/hea0000736. Epub 2019 Apr 11.

15:Rasagiline and safinamide as a dopamine-sparing therapy for Parkinson's disease.
Authors:Avila A, Caballol N, Martin-Baranera M, Gomez-Ruiz I, Balague-Marmana M, Planas-Ballve A, Cardona X
Institution:Department of Neurology, Hospital Sant Joan Despi Moises Broggi and Hospital General de l'Hospitalet, Consorci Sanitari Integral, Barcelona, Spain.; Department of Clinical Epidemiology, Hospital Sant Joan Despi Moises Broggi and Hospital General de l'Hospitalet, Consorci Sanitari Integral, Barcelona, Spain.; Department of Psychiatry, Hospital Sant Joan Despi Moises Broggi and Hospital General de l'Hospitalet, Consorci Sanitari Integral, Barcelona, Spain.
Journal:Acta Neurol Scand. 2019 Jul;140(1):23-31. doi: 10.1111/ane.13096. Epub 2019 Apr 22.

16:Quality of life in Parkinson's disease: A gender-specific perspective.
Authors:Balash Y, Korczyn AD, Migirov AA, Gurevich T
Institution:Movement Disorders Unit, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel.
Journal:Acta Neurol Scand. 2019 Jul;140(1):17-22. doi: 10.1111/ane.13095. Epub 2019 Apr 23.

17:Therapeutic potentials of plant iridoids in Alzheimer's and Parkinson's diseases: A review.
Authors:Dinda B, Dinda M, Kulsi G, Chakraborty A, Dinda S
Institution:Department of Chemistry, Tripura University, Suryamaninagar, Agartala, Tripura, 799 022, India. Electronic address: of Medicine, Charlottesvile, 1300 Jefferson Park Ave, VA, 22908, USA. 151742, Republic of Korea. 799 022, India. India.
Journal:Eur J Med Chem. 2019 May 1;169:185-199. doi: 10.1016/j.ejmech.2019.03.009. Epub 2019 Mar 8.

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