Trigeminal Neuralgia
March 2021 Issue

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Trigeminal Neuralgia abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Trigeminal Neuralgia. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Trigeminal Neuralgia. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Trigeminal Neuralgia every 3 months. Thank you for your ongoing subscription to this publication.

Elliot Jacob, Ph.D.
Vice-President - Content, Inc.

1:Tooth-supported personalized template-assisted foramen ovale puncture system for trigeminal neuralgia treatment.
Authors:Han ZX, Chen MJ, Zhang WJ, Chai Y, Zhang WH
Institution:Department of Oral Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, 639 Zhi Zao Ju Road, Shanghai 200011, PR China.
Journal:J Clin Neurosci. 2020 Dec;82(Pt A):71-75. doi: 10.1016/j.jocn.2020.10.039. Epub 2020 Nov 8.

2:Burden of illness of trigeminal neuralgia among patients managed in a specialist center in England.
Authors:O'Callaghan L, Floden L, Vinikoor-Imler L, Symonds T, Giblin K, Hartford C, Zakrzewska JM
Institution:Biogen, 225 Binney St, Cambridge, MA, 02142, USA. Royal National ENT & Eastman Dental Hospitals, 4th Floor Central, 250 Euston Road, London, NW1 2PQ, UK.
Journal:J Headache Pain. 2020 Nov 10;21(1):130. doi: 10.1186/s10194-020-01198-z.

3:Cryoneurotomy in the management of intractable trigeminal neuralgia.
Authors:Goss A, Ito K
Institution:Oral & Maxillofacial Surgery Unit, The University of Adelaide, South Australia; Chronic Pain Unit, Royal Adelaide Hospital, South Australia. Electronic address: Oral & Maxillofacial Surgery Unit, The University of Adelaide, South Australia; Department of Oral and Maxillofacial Surgery, Faculty of Medicine, Saitama Medical University, Saitama, Japan.
Journal:Br J Oral Maxillofac Surg. 2020 Nov;58(9):1187-1192. doi: 10.1016/j.bjoms.2020.08.073. Epub 2020 Aug 29.

4:Interventional Management of Refractory Trigeminal Neuropathic Pain: A Prospective Audit of a Novel Management Pathway in 70 Patients.
Authors:Niraj G, Simpson L, Raithatha B
Institution:University Hospitals of Leicester NHS Trust, United Kingdom. University Hospitals of Leicester NHS Trust, Leicester, UK.
Journal:Pain Physician. 2020 Sep;23(5):E525-E534.

5:Advances in diagnosis, classification, pathophysiology, and management of trigeminal neuralgia.
Authors:Bendtsen L, Zakrzewska JM, Heinskou TB, Hodaie M, Leal PRL, Nurmikko T, Obermann M, Cruccu G, Maarbjerg S
Institution:Department of Neurology, Danish Headache Center, Rigshospitalet, Glostrup, Denmark. Electronic address:
Journal:Lancet Neurol. 2020 Sep;19(9):784-796. doi: 10.1016/S1474-4422(20)30233-7.

6:Cognitive and sensorimotor function in participants being treated for trigeminal neuralgia pain.
Authors:Coats RO, Crossley KL, Conlin N, Wu J, Zakrzewska JM, Pavitt SH, Phillips N, Mon-Williams M
Institution:School of Psychology, University of Leeds, Leeds, LS2 9JT, UK.
Journal:J Headache Pain. 2020 Jul 17;21(1):91. doi: 10.1186/s10194-020-01156-9.

7:Pitfals in recognition and management of trigeminal neuralgia.
Authors:Antonaci F, Arceri S, Rakusa M, Mitsikostas DD, Milanov I, Todorov V, Ramusino MC, Costa A
Institution:IRCCS Mondino Foundation, Pavia, Italy.
Journal:J Headache Pain. 2020 Jun 30;21(1):82. doi: 10.1186/s10194-020-01149-8.

8:Surgical Treatment of Secondary Trigeminal Neuralgia Induced by Cerebellopontine Angle Tumors: A Single-Center Experience.
Authors:Zhang YQ, Yu F, Zhao ZY, Men XZ, Shi W
Institution:Department of Neurosurgery, PLA 960th Hospital, Jinan, China.
Journal:World Neurosurg. 2020 Sep;141:e508-e513. doi: 10.1016/j.wneu.2020.05.226. Epub 2020 May 31.

9:Outcomes of Treatment for Elderly Patients With Trigeminal Neuralgia: Percutaneous Balloon Compression Versus Microvascular Decompression.
Authors:Ni H, Wang Y, Chen X, Gu W
Institution:Department of Anesthesiology and Pain, Siyang Hospital of Traditional Chinese Medicine, Siyang. Department of Emergency, Suqian People's Hospital of Nanjing Drum-Tower Hospital Group, Suqian, China.
Journal:J Craniofac Surg. 2020 Oct;31(7):e685-e688. doi: 10.1097/SCS.0000000000006544.

10:Delayed Contralateral Trigeminal Neuralgia After Microvascular Decompression and Postoperative Changes in Venous Outflow.
Authors:Eibach S, Steinfort B, Di Ieva A
Institution:Macquarie Neurosurgery, Department of Clinical Medicine, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, Australia; Department of Paediatric Neurosurgery, Sydney Children's Hospital Randwick, Sydney, Australia. Electronic address: Macquarie Neurosurgery, Department of Clinical Medicine, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, Australia; Computational NeuroSurgery Laboratory, Department of Clinical Medicine, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, Australia.
Journal:World Neurosurg. 2020 Aug;140:107-108. doi: 10.1016/j.wneu.2020.05.041. Epub 2020 May 12.

11:Predictors of the Analgesic Efficacy of CT-Guided Percutaneous Pulsed Radiofrequency Treatment of Gasserian Ganglion in Patients With Idiopathic Trigeminal Neuralgia.
Authors:Ren H, Zhao C, Jia Z, Bian J, Luo F
Institution:Department of Pain Management, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Journal:Pain Pract. 2020 Nov;20(8):850-858. doi: 10.1111/papr.12910. Epub 2020 Jun 30.

12:Percutaneous Trigeminal Stimulation for Intractable Facial Pain: A Case Series.
Authors:Texakalidis P, Tora MS, McMahon JT, Greven A, Anthony CL, Nagarajan P, Campbell M, Boulis NM
Institution:Department of Neurosurgery, School of Medicine, Emory University, Atlanta, Georgia.
Journal:Neurosurgery. 2020 Sep 1;87(3):547-554. doi: 10.1093/neuros/nyaa065.

13:Trigeminal neuralgia in multiple sclerosis: Prevalence and association with demyelination.
Authors:Laakso SM, Hekali O, Kurdo G, Martola J, Sairanen T, Atula S
Institution:Department of Neurosciences, University of Helsinki, Helsinki, Finland.
Journal:Acta Neurol Scand. 2020 Aug;142(2):139-144. doi: 10.1111/ane.13243. Epub 2020 Apr 3.

14:Quantitative Sensory Changes Following Gasserian Ganglion Radiofrequency Thermocoagulation in Patients with Medical Refractory Trigeminal Neuralgia: A Prospective Consecutive Case Series.
Authors:Huckhagel T, Bohlmann L, Westphal M, Regelsberger J, Eichler IC, Hamel W
Institution:Department of Neurosurgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Journal:J Neurol Surg A Cent Eur Neurosurg. 2020 Sep;81(5):423-429. doi: 10.1055/s-0039-1698386. Epub 2020 Jan 21.

15:Case report: successful treatment of a patient with trigeminal neuropathy using ziconotide.
Authors:Lux EA
Institution:Clinic of Pain and Palliative Medicine, St.-Marien-Hospital, Lunen, Germany.
Journal:Anesth Analg. 2010 Apr 1;110(4):1195-7. Epub 2010 Feb 8.

16:Keyhole microsurgery for trigeminal neuralgia, hemifacial spasm and glossopharyngeal neuralgia.
Authors:Ma Z, Li M, Cao Y, Chen X
Institution:Department of Otolaryngology-Head and Neck Surgery, East Hospital Affiliated to Tongji University, Shanghai, China.
Journal:Eur Arch Otorhinolaryngol. 2010 Mar;267(3):449-54. Epub 2009 Jun 18.

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