Trigeminal Neuralgia
March 2022 Issue

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Trigeminal Neuralgia abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Trigeminal Neuralgia. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Trigeminal Neuralgia. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Trigeminal Neuralgia every 3 months. Thank you for your ongoing subscription to this publication.

Elliot Jacob, Ph.D.
Vice-President - Content, Inc.

1:Treatment of redo-microvascular decompression or internal neurolysis plus microvascular decompression for recurrent trigeminal neuralgia: a review of long-term effectiveness and safety.
Authors:Wang B, Zhang L, Yu Y
Institution:Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, People's Republic of China.
Journal:J Int Med Res. 2022 Mar;50(3):3000605221080721. doi: 10.1177/03000605221080721.

2:Predictive and prognostic factors for outcome of microvascular decompression in trigeminal neuralgia.
Authors:Huang CW, Yang MY, Cheng WY, Pan SY, Wang CL, Lai WY, Lin TW, Liu SY, Huang YF, Lai CM, Shen CC
Institution:Department of Neurosurgery, Neurological Institute, Taichung Veterans General Hospital, Taichung, Taiwan, ROC.
Journal:J Chin Med Assoc. 2022 Feb 1;85(2):198-203. doi: 10.1097/JCMA.0000000000000667.

3:Analysis of short-term efficacy of radiofrequency thermocoagulation in the treatment of classic trigeminal neuralgia.
Authors:Wang Q, Du WJ
Institution:Department of Pain, Shanxi Bethune Hospital, Taiyuan, Shanxi, China. Department of Orthopedics, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China, China.
Journal:Agri. 2022 Jan;34(1):1-6. doi: 10.14744/agri.2021.42800.

4:Prevalence of trigeminal neuralgia in multiple sclerosis: A systematic review and meta-analysis.
Authors:Houshi S, Tavallaei MJ, Barzegar M, Afshari-Safavi A, Vaheb S, Mirmosayyeb O, Shaygannejad V
Institution:Department of Neurology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Journal:Mult Scler Relat Disord. 2022 Jan;57:103472. doi: 10.1016/j.msard.2021.103472. Epub 2021 Dec 29.

5:Intravenous fosphenytoin therapy for rescue of acute trigeminal neuralgia crisis in patients awaiting neurosurgical procedures: A cross-sectional study.
Authors:Noro S, Seo Y, Honjo K, Okuma M, Asayama B, Amano Y, Kyono M, Sako K, Nakamura H
Institution:Department of Neurosurgery, Nakamura Memorial Hospital, Sapporo, Japan. Electronic address:
Journal:J Clin Neurosci. 2021 Dec;94:59-64. doi: 10.1016/j.jocn.2021.09.040. Epub 2021 Oct 11.

6:Pharmacologic Management of Neuropathic Pain.
Authors:Nudell Y, Dym H, Sun F, Benichou M, Malakan J, Halpern LR
Institution:Oral and Maxillofacial Surgery, The Brooklyn Hospital Center, 155 Ashland Place, Brooklyn, NY 11201, USA. Electronic address: The University of Utah, School of Dentistry, 530 South Wakara Way, Salt Lake City, UT 84108, USA.
Journal:Oral Maxillofac Surg Clin North Am. 2022 Feb;34(1):61-81. doi: 10.1016/j.coms.2021.09.002.

7:Long-term Follow-up of Pulsed Radiofrequency Treatment for Trigeminal Neuralgia: Kaplan-Meier Analysis in a Consecutive Series of 149 Patients.
Authors:Zipu J, Hao R, Chunmei Z, Lan M, Ying S, Fang L
Institution:Department of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University; Beijing, China. Department of Pain Management, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Journal:Pain Physician. 2021 Dec;24(8):E1263-E1271.

8:The Analysis of Percutaneous Balloon Compression on Efficacy and Negative Emotion in the Treatment of Recurrent Trigeminal Neuralgia After Surgical Procedures.
Authors:Fan X, Xu F, Ren H, Lu Z, Bu H, Ma L, Kong C, Wang T
Institution:Center of Pain Medicine, Department of Anesthesiology, pain, and Perioperative Medicine, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Journal:Pain Physician. 2021 Dec;24(8):E1255-E1262.

9:Comparison of Efficacy and Safety of CT-Guided Radiofrequency Thermocoagulation Through Foramen Rotundum Versus Foramen Ovale for V2 Primary Trigeminal Neuralgia.
Authors:Ding Y, Yao P, Li H, Hong T
Institution:Department of Pain Management, Shengjing Hospital of China Medical University, Shenyang, China.
Journal:Pain Physician. 2021 Dec;24(8):587-596.

10:External Neurolysis in Microvascular Decompression for Magnetic Resonance Imaging-Negative Idiopathic Trigeminal Neuralgia.
Authors:Son BC, Lee CI, Choi JG
Institution:Department of Neurosurgery, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea; Catholic Neuroscience Institute, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea. Electronic address: Department of Neurosurgery, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Journal:World Neurosurg. 2022 Jan;157:e448-e460. doi: 10.1016/j.wneu.2021.10.120. Epub 2021 Oct 21.

11:Microvascular decompression in trigeminal neuralgia: predictors of pain relief, complication avoidance, and lessons learned.
Authors:Herta J, Schmied T, Loidl TB, Wang WT, Marik W, Winter F, Tomschik M, Ferraz-Leite H, Rössler K, Dorfer C
Institution:Department of Neurosurgery, Medical University of Vienna, Wahringer Gurtel 18-20, 1090, Vienna, Austria.
Journal:Acta Neurochir (Wien). 2021 Dec;163(12):3321-3336. doi: 10.1007/s00701-021-05028-2. Epub 2021 Oct 21.

12:Clinical effectiveness of peripheral nerve blocks with lidocaine and corticosteroid in patients with trigeminal neuralgia.
Authors:Balta S, Köknel Talu G
Institution:Department of Algology, Konya Training and Research Hospital University of Health Sciences, Konya, Turkey. Division of Algology, Department of Anestesiology and Reanimation, ?stanbul University ?stanbul Faculty of Medicine, Konya, Turkey.
Journal:Agri. 2021 Oct;33(4):237-242. doi: 10.14744/agri.2021.26032.

13:Characteristics and natural disease history of persistent idiopathic facial pain, trigeminal neuralgia, and neuropathic facial pain.
Authors:Ziegeler C, Brauns G, May A
Institution:Department of Systems Neuroscience, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. Hamburg, Germany.
Journal:Headache. 2021 Oct;61(9):1441-1451. doi: 10.1111/head.14212. Epub 2021 Oct 7.

14:Role of Gamma Knife radiosurgery in trigeminal neuralgia - Its long term outcome and prediction using Artificial neural Network model.
Authors:Goyal S, Kedia S, Kumar R, Bisht RK, Agarwal D, Singh M, Sawarkar D, Kale SS
Institution:Department of Neurosurgery, All India Institute of Medical Sciences, New Delhi, India.
Journal:J Clin Neurosci. 2021 Oct;92:61-66. doi: 10.1016/j.jocn.2021.07.017. Epub 2021 Aug 5.

15:The effectiveness and safety of neurosurgical treatment via retrosigmoid approach in elderly patients with trigeminal neuralgia.
Authors:Sun J, Zhu J, Zhang L, Yu Y
Institution:Department of Neurosurgery, China-Japan Friendship Hospital, Beijing, Chaoyang District 100029, China. District 100029, China. District 100029, China. District 100029, China. Electronic address:
Journal:J Clin Neurosci. 2021 Oct;92:27-32. doi: 10.1016/j.jocn.2021.07.045. Epub 2021 Aug 2.

16:Efficacy and Safety of Awake Computed Tomography-Guided Percutaneous Balloon Compression of Trigeminal Ganglion for Trigeminal Neuralgia.
Authors:Huang B, Yao M, Chen Q, Du X, Li Z, Xie K, Fei Y, Do H, Qian X
Institution:Department of Anesthesiology and Pain Medicine, The Affiliated Hospital of Jiaxing University, Jiaxing, China. University, Jiaxing, China.
Journal:Pain Med. 2021 Nov 26;22(11):2700-2707. doi: 10.1093/pm/pnab228.

17:Microvascular decompression for trigeminal neuralgia due to vertebrobasilar artery compression: a systematic review and meta-analysis.
Authors:Di Carlo DT, Benedetto N, Marani W, Montemurro N, Perrini P
Institution:Department of Neurosurgery, Azienda Ospedaliero Universitaria Pisana (AOUP), Via Paradisa 2, 56100, Pisa, Italy.
Journal:Neurosurg Rev. 2022 Feb;45(1):285-294. doi: 10.1007/s10143-021-01606-1. Epub 2021 Jul 26.

18:Microvascular decompression as a second step treatment for trigeminal neuralgia in patients with failed two-isocentre gamma knife radiosurgery.
Authors:Wang JJ, Zhao Z, Chai SS, Wang YH, Xiang W
Institution:Department of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue No.1277, Wuhan, 430022, People's Republic of China.
Journal:Neurosurg Rev. 2022 Feb;45(1):783-791. doi: 10.1007/s10143-021-01587-1. Epub 2021 Jul 22.

19:Trigeminal neuralgia: a practical guide.
Authors:Lambru G, Zakrzewska J, Matharu M
Institution:The Headache Service, Pain Management and Neuromodulation Centre, Guy's and St Thomas' Hospitals NHS Trust, London, UK. Headache and Facial Pain Group, UCL Queen Square Institute of Neurology, London, UK
Journal:Pract Neurol. 2021 Oct;21(5):392-402. doi: 10.1136/practneurol-2020-002782. Epub 2021 Jun 9.

20:Prognostic nomogram for percutaneous balloon compression in the treatment of trigeminal neuralgia.
Authors:Liu M, Tang S, Li T, Xu Z, Li S, Zhou Y, Li L, Wang W, Shi J, Shi W
Institution:Department of Neurosurgery, Qingdao Municipal Hospital, No.1 Jiaozhou Rd, Qingdao City, 266000, China. Department of Orthopedic, Taizhou First People's Hospital, Wenzhou Medical University, Taizhou, 318020, Zhejiang Province, China.
Journal:Neurosurg Rev. 2022 Feb;45(1):561-569. doi: 10.1007/s10143-021-01514-4. Epub 2021 May 24.

21:Does the Surgical Intervention for Trigeminal Neuralgia Refractory to Pharmacotherapy Improve Quality-of-Life? - A Systematic Review.
Authors:Diana C, Kumar RD, Bodh R, Kumari S
Institution:Assistant Professor, Department of Oral and Maxillofacial Surgery, CSI college of dental sciences and research, Madurai,Tamil Nadu, India. Senior Resident, Department of Oral and Maxillofacial Surgery, Maulana Azad Institute of Dental Sciences, New Delhi, India.
Journal:J Oral Maxillofac Surg. 2021 Nov;79(11):2227-2239. doi: 10.1016/j.joms.2021.03.003. Epub 2021 Mar 10.

22:Efficacy of Gamma Knife radiosurgery in the management of multiple sclerosis-related trigeminal neuralgia: a systematic review and meta-analysis.
Authors:Spina A, Nocera G, Boari N, Iannaccone S, Mortini P
Institution:Department of Neurosurgery and Gamma Knife Radiosurgery, I.R.C.C.S. San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy.
Journal:Neurosurg Rev. 2021 Dec;44(6):3069-3077. doi: 10.1007/s10143-021-01507-3. Epub 2021 Feb 20.

23:Factors affecting long-lasting pain relief after Gamma Knife radiosurgery for trigeminal neuralgia: a single institutional analysis and literature review.
Authors:Barzaghi LR, Albano L, Scudieri C, Gigliotti CR, Del Vecchio A, Mortini P
Institution:Department of Neurosurgery and Gamma Knife Radiosurgery, IRCCS San Raffaele Scientific Institute and Vita-Salute University, Via Olgettina 60, 20132, Milan, Italy.
Journal:Neurosurg Rev. 2021 Oct;44(5):2797-2808. doi: 10.1007/s10143-021-01474-9. Epub 2021 Jan 12.

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