Trigeminal Neuralgia
May 2020 Issue

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Trigeminal Neuralgia abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Trigeminal Neuralgia. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Trigeminal Neuralgia. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Trigeminal Neuralgia every 3 months. Thank you for your ongoing subscription to this publication.

Elliot Jacob, Ph.D.
Vice-President - Content, Inc.

1:Electroacupuncture therapy for change of pain in classical trigeminal neuralgia.
Authors:Sun J, Li R, Li X, Chen L, Liang Y, Zhang Q, Sun R, Hu H, Shao X, Fang J
Institution:The Third Clinical Medical College, Zhejiang Chinese Medical University, Key Laboratory of Acupuncture and Neurology of Zhejiang Province.
Journal:Medicine (Baltimore). 2020 Apr;99(16):e19710. doi: 10.1097/MD.0000000000019710.

2:Idiopathic Trigeminal Neuralgia (ITN): Facts and Fiction.
Authors:Zurak N, Mahovic D
Institution:School of Medicine, University of Zagreb, Zagreb, Croatia.
Journal:Psychiatr Danub. 2019 Dec;31(Suppl 5):724-731.

3:Risk Factors for Outcomes After Microvascular Decompression for Trigeminal Neuralgia.
Authors:Shi J, Qian Y, Han W, Dong B, Mao Y, Cao J, Guan W, Zhou Q
Institution:Department of Neurosurgery, Third Affiliated Hospital of Soochow University, Changzhou, China. Electronic address:
Journal:World Neurosurg. 2020 Apr;136:e559-e566. doi: 10.1016/j.wneu.2020.01.082. Epub 2020 Jan 17.

4:Microvascular Decompression for Trigeminal Neuralgia in Patients with Multiple Sclerosis: Predictors of Treatment Success.
Authors:Paulo DL, Lopez AM, Jermakowicz WJ, Yu H, Shah H, Konrad PE, Englot DJ
Institution:Department of Neurological Surgery, Vanderbilt University School of Medicine, Nashville, Tennessee, USA. Electronic address:
Journal:World Neurosurg. 2020 Apr;136:e165-e170. doi: 10.1016/j.wneu.2019.12.081. Epub 2019 Dec 23.

5:Radiofrequency Thermocoagulation Through Foramen Rotundum Versus Foramen Ovale for the Treatment of V2 Trigeminal Neuralgia.
Authors:Xue TQ, Zhang QX, Bian H, Zhou PC, Liu C, Niu SF, Wang ZB, Shi WJ, Yan CY
Institution:Department of Pain and Intervention Management, Huaian Hospital of Huaian City, Huaian, Jiangsu, China. Department of Neurology, Lianshui People's Hospital, Huaian, Jiangsu, China.
Journal:Pain Physician. 2019 Nov;22(6):E609-E614.

6:Effect of Training on Percutaneous Glycerol Rhizotomy for Trigeminal Neuralgia: A Long-Term, Retrospective Comparison of Staff Neurosurgeon and Trainee Complications and Efficacy.
Authors:Joswig H, Staudt MD, MacDougall KW, Parrent AG
Institution:Division of Neurosurgery, Department of Clinical Neurological Sciences, London Health Sciences Centre, Western University, London, Ontario, Canada; Department of Neurosurgery, Ernst von Bergmann Hospit Division of Neurosurgery, Department of Clinical Neurological Sciences, London Health Sciences Centre, Western University, London, Ontario, Canada.
Journal:World Neurosurg. 2020 Feb;134:e1001-e1007. doi: 10.1016/j.wneu.2019.11.058. Epub 2019 Nov 19.

7:Ruptured Distal Superior Cerebellar Artery Aneurysm After Gamma Knife Radiosurgery for Trigeminal Neuralgia: A Case Report and Review of the Literature.
Authors:Dominguez L, Saway B, Benko MJ, Guilliams E, Marvin EA, Entwistle JJ
Institution:Mayo Clinic School of Graduate Medical Education, Jacksonville, Florida, USA. Electronic address: Department of Surgery, Division of Neurosurgery, Virginia Tech Carilion School of Medicine and Fralin Biomedical Research Institute, Roanoke, Virginia, USA.
Journal:World Neurosurg. 2020 Mar;135:2-6. doi: 10.1016/j.wneu.2019.10.136. Epub 2019 Nov 14.

8:Posterior Ischemic Optic Neuropathy Following Radiofrequency Thermocoagulation for the Treatment of Trigeminal Neuralgia.
Authors:Cai Y, Cai XL
Institution:Department of Ophthalmology. Department of Oral and Maxillofacial Surgery, Hebei Eye Hospital, Xingtai, Hebei, China.
Journal:J Craniofac Surg. 2019 Nov-Dec;30(8):2576-2577. doi: 10.1097/SCS.0000000000006072.

9:Sphenopalatine Ganglion Block with Botulinum Neurotoxin for Treating Trigeminal Neuralgia Using CAD/CAM-Derived Injection Guide.
Authors:Yoshida K
Journal:J Oral Facial Pain Headache. 2020 Spring;34(2):135–140. doi: 10.11607/ofph.2510. Epub 2019 Sep 27.

10:Minimally invasive trigeminal ablation in patients with refractory trigeminal neuralgia who are ineligible for intracranial intervention.
Authors:Tajali Y, Ward M, Abraham M, Hillen M, Mahmoud O, Herschman Y, Mammis A, Paskhover B
Institution:Department of Neurology, Rutgers New Jersey Medical School, Newark, NJ, United States. Department of Otolaryngology - Head and Neck Surgery, Rutgers New Jersey Medical School, Newark, NJ, United States; Department of Facial Plastic Surgery, Rutgers New Jersey Medical School, Newark, NJ,
Journal:J Clin Neurosci. 2019 Dec;70:42-46. doi: 10.1016/j.jocn.2019.09.002. Epub 2019 Sep 16.

11:Repeat gamma knife stereotactic radiosurgery in the treatment of trigeminal neuralgia: A single-center experience and focused review of the literature.
Authors:Omar NB, Amburgy JW, Self DM, Christen AM, Larios EA, Ditty BJ, Jacob R, Fiveash J, Spencer S, Markert JM, Guthrie BL, Fisher WS, Chambers MR
Institution:Department of Neurosurgery, The University of Alabama at Birmingham, Birmingham, AL, United States. Electronic address:
Journal:J Clin Neurosci. 2019 Dec;70:102-107. doi: 10.1016/j.jocn.2019.08.061. Epub 2019 Aug 22.

12:Efficacy of gabapentin in the treatment of trigeminal neuralgia: A systematic review of randomized controlled trials.
Authors:Ta PCP, Dinh HQ, Nguyen K, Lin S, Ong YL, Ariyawardana A
Institution:College of Medicine and Dentistry, James Cook University, Cairns, QLD, Australia.
Journal:J Investig Clin Dent. 2019 Nov;10(4):e12448. doi: 10.1111/jicd.12448. Epub 2019 Aug 11.

13:Outcomes and Safety of Overlapping Surgery in Patients Undergoing Microvascular Decompression for Hemifacial Spasm and Trigeminal Neuralgia.
Authors:Min L, Liu M, Zhang W, Tao B, Sun Q, Li S, Wang X
Institution:Neurosurgery Department, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. Electronic address:
Journal:World Neurosurg. 2019 Oct;130:e1084-e1090. doi: 10.1016/j.wneu.2019.07.092. Epub 2019 Jul 16.

14:Vascular Complications in Microvascular Decompression: A Survey of 4000 Operations.
Authors:Lee S, Park SK, Joo BE, Lee JA, Park K
Institution:Department of Neurosurgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. Electronic address:
Journal:World Neurosurg. 2019 Oct;130:e577-e582. doi: 10.1016/j.wneu.2019.06.155. Epub 2019 Jun 26.

15:Prognosis Comparison of Different Branches of Trigeminal Neuralgia.
Authors:Zhang WB, Min LZ, Tao BB, Sun QY, Li ST, Wang XQ
Institution:Department of Neurosurgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China; Center for Diagnosis and Treatment of Cranial Nerve Diseases, Shanghai Jiao Tong Universit
Journal:World Neurosurg. 2020 Jan;133:e1-e5. doi: 10.1016/j.wneu.2019.06.115. Epub 2019 Jun 25.

16:Gamma Knife Radiosurgery for Multiple Sclerosis-Associated Trigeminal Neuralgia.
Authors:Helis CA, McTyre E, Munley MT, Bourland JD, Lucas JT, Cramer CK, Tatter SB, Laxton AW, Chan MD
Institution:Department of Radiation Oncology, Wake Forest Baptist Medical Center, Winston-Salem, North Carolina.
Journal:Neurosurgery. 2019 Nov 1;85(5):E933-E939. doi: 10.1093/neuros/nyz182.

17:The Effectiveness of Percutaneous Balloon Compression, Thermocoagulation, and Glycerol Rhizolysis for Trigeminal Neuralgia in Multiple Sclerosis.
Authors:Noorani I, Lodge A, Vajramani G, Sparrow O
Institution:Department of Neurosurgery, Wessex Neurological Centre, University Hospital Southampton, Southampton, United Kingdom.
Journal:Neurosurgery. 2019 Oct 1;85(4):E684-E692. doi: 10.1093/neuros/nyz103.

18:Predictive value of magnetic resonance for identifying neurovascular compressions in trigeminal neuralgia.
Authors:Ruiz-Juretschke F, Guzmán-de-Villoria JG, García-Leal R, Sañudo JR
Institution:Servicio de Neurocirugia, Hospital General Universitario Gregorio Maranon, Madrid, Espana. Electronic address: Departamento de Anatomia y Embriologia Humana, Facultad de Medicina, Universidad Complutense de Madrid, Madrid, Espana.
Journal:Neurologia. 2019 Oct;34(8):510-519. doi: 10.1016/j.nrl.2017.03.007. Epub 2017 May 23.

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