Peripheral Neuropathy
March 2022 Issue

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Peripheral Neuropathy abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Peripheral Neuropathy. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Peripheral Neuropathy. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Peripheral Neuropathy every 3 months. Thank you for your ongoing subscription to this publication.

Elliot Jacob, Ph.D.
Vice-President - Content, Inc.

1:Peripheral Neuropathy Evaluations of Patients With Prolonged Long COVID.
Authors:Oaklander AL, Mills AJ, Kelley M, Toran LS, Smith B, Dalakas MC, Nath A
Institution:From the Nerve Unit (A.L.O., A.J.M.), Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston; Department of Pathology (Neuropathology) (A.L.O.), Massachusetts General Hospital, Boston, Massachusetts; Department of Neurology (M.K.), Dell Medical School, The University of Texas, Austin, Texas; Department of Neurology (L.S.T.), Confluence Health, Wenatchee; Section of Infections of the Nervous System (B.S., A.N.), National Institute of Neurological Disorders and Stroke (NINDS) at the National Institutes of Health (NIH), Bethesda, Maryland; and Neuromuscular Division (M.C.D.), Department of Neurology, Thomas Jefferson University, Philadelphia, Pennsylvania, and National and Kapodistrian University of Athens Medical School, Greece.
Journal:Neurol Neuroimmunol Neuroinflamm. 2022 Mar 1;9(3):e1146. doi: 10.1212/NXI.0000000000001146. Print 2022 May.

2:Effects of Transcutaneous Electrical Nerve Stimulation on Pain and Chemotherapy-Induced Peripheral Neuropathy in Cancer Patients: A Systematic Review.
Authors:Püsküllüoğlu M, Tomaszewski KA, Grela-Wojewoda A, Pacholczak-Madej R, Ebner F
Institution:Department of Clinical Oncology, Maria Sklodowska-Curie National Research Institute of Oncology, Krakow Branch, 00-001 Krakow, Poland. Helios Amper-Klinikum Dachau, Akademisches Lehrkrankenhaus der Ludwig-Maximilians-Universitat, 85221 Munchen, Germany.
Journal:Medicina (Kaunas). 2022 Feb 14;58(2):284. doi: 10.3390/medicina58020284.

3:The characteristics of pain and dysesthesia in patients with diabetic polyneuropathy.
Authors:Gylfadottir SS, Itani M, Kristensen AG, Karlsson P, Krøigård T, Bennett DL, Tankisi H, Andersen NT, Jensen TS, Sindrup SH, Finnerup NB
Institution:Danish Pain Research Center, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Journal:PLoS One. 2022 Feb 17;17(2):e0263831. doi: 10.1371/journal.pone.0263831. eCollection 2022.

4:Negative pressure wound therapy, artificial skin and autogenous skin implantation in diabetic foot ulcers.
Authors:Chia-Jui H, Yu L, Jiang YQ, Tan W, Gao GM, Li HB, Han L
Institution:Department of Orthopedics, Xiamen ChangGung Hospital, Xiamen City, Fujian Province, China. Department of Orthopedics, The Affiliated Changzhou No.2 People's Hospital of Nanjing Medical University, Changzhou City, Jiangsu Province, China.
Journal:J Wound Care. 2022 Jan 2;31(1):40-46. doi: 10.12968/jowc.2022.31.1.40.

5:Neuromuscular dysfunction and exercise training in people with diabetic peripheral neuropathy: A narrative review.
Authors:Orlando G, Balducci S, Boulton AJM, Degens H, Reeves ND
Institution:Research Centre for Musculoskeletal Science & Sports Medicine, Department of Life Sciences, Faculty of Science and Engineering, Manchester Metropolitan University, Manchester, UK. Electronic address:
Journal:Diabetes Res Clin Pract. 2022 Jan;183:109183. doi: 10.1016/j.diabres.2021.109183. Epub 2021 Dec 17.

6:Clinical and preclinical features of eribulin-related peripheral neuropathy.
Authors:Tarasiuk O, Cavaletti G, Meregalli C
Institution:School of Medicine and Surgery, Experimental Neurology Unit and Milan Center for Neuroscience, University of Milano-Bicocca, Monza, Italy.
Journal:Exp Neurol. 2022 Feb;348:113925. doi: 10.1016/j.expneurol.2021.113925. Epub 2021 Nov 18.

7:Updates in diabetic neuropathy: A call for new diagnostic and treatment approaches.
Authors:Aso Y
Institution:Department of Endocrinology and Metabolism, Dokkyo Medical University, Shimotsuga, Japan.
Journal:J Diabetes Investig. 2022 Mar;13(3):432-434. doi: 10.1111/jdi.13711. Epub 2021 Dec 7.

8:Diabetic Peripheral Neuropathy and Urological Complications in Type 1 Diabetes: Findings From the Epidemiology of Diabetes Interventions and Complications Study.
Authors:Pop-Busui R, Braffett BH, Wessells H, Herman WH, Martin CL, Jacobson AM, Sarma AV
Institution:1Division of Metabolism, Endocrinology and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, MI. 5Department of Urology, University of Michigan, Ann Arbor, MI.
Journal:Diabetes Care. 2022 Jan 1;45(1):119-126. doi: 10.2337/dc21-1276.

9:Acceptance of illness, quality of life and nutritional status of patients after lower limb amputation due to diabetes mellitus.
Authors:Juzwiszyn J, Łabuń A, Tański W, Szymańska-Chabowska A, Zielińska D, Chabowski M
Institution:Division of Nervous System Diseases, Department of Clinical Nursing, Faculty of Health Science, Wroclaw Medical University, Wroclaw, Poland. Department of Surgery, 4(th) Military Teaching Hospital, Wroclaw, Poland.; Division of Oncology and Palliative Care, Department of Clinical Nursing, Faculty of Health Science, Wroclaw Medical University, Wroclaw, Poland.. Electronic address:
Journal:Ann Vasc Surg. 2022 Feb;79:208-215. doi: 10.1016/j.avsg.2021.07.023. Epub 2021 Oct 10.

10:Treatment strategy of oxaliplatin-induced peripheral neuropathy: a retrospective, nationwide study.
Authors:Yokoyama S, Nakagawa C, Hosomi K
Institution:Division of Drug Informatics, School of Pharmacy, Kindai University, 3-4-1 Kowakae, Higashiosaka City, Osaka, 577-8502, Japan.
Journal:Support Care Cancer. 2022 Feb;30(2):1765-1773. doi: 10.1007/s00520-021-06585-z. Epub 2021 Oct 1.

11:Risk factors for depression and anxiety in painful and painless diabetic polyneuropathy: A multicentre observational cross-sectional study.
Authors:Kec D, Rajdova A, Raputova J, Adamova B, Srotova I, Nekvapilova EK, Michalcakova RN, Horakova M, Belobradkova J, Olsovsky J, Weber P, Hajas G, Kaiserova M, Mazanec R, Potockova V, Ehler E, Forgac M, Birklein F, Üçeyler N, Sommer C, Bednarik J, Vlckova E
Institution:Department of Neurology, Center for Neuromuscular Diseases (Associated National Center in the European Reference Network ERN EURO-NMD), University Hospital Brno, Brno, Czech Republic.
Journal:Eur J Pain. 2022 Feb;26(2):370-389. doi: 10.1002/ejp.1865. Epub 2021 Oct 10.

12:Contribution of peripheral neuropathy to poor bone health in the feet of people with type 2 diabetes mellitus.
Authors:Lasschuit JWJ, Greenfield JR, Tonks KTT
Institution:Department of Endocrinology and Diabetes, St Vincent's Hospital, Sydney, NSW, Australia.
Journal:Acta Diabetol. 2022 Feb;59(2):217-224. doi: 10.1007/s00592-021-01803-w. Epub 2021 Sep 26.

13:Effect of caffeine on the possible amelioration of diabetic neuropathy: A spectroscopic study.
Authors:Srivastava B, Sen S, Bhakta S, Sen K
Institution:Department of Chemistry, University of Calcutta, 92 A. P. C. Road, Kolkata 700009, India.
Journal:Spectrochim Acta A Mol Biomol Spectrosc. 2022 Jan 5;264:120322. doi: 10.1016/j.saa.2021.120322. Epub 2021 Aug 27.

14:Predictive factors of functional abilities in older patients with peripheral neuropathy.
Authors:Gialanella B, Prometti P, Comini L, Monguzzi V, Santoro R
Institution:Istituti Clinici Scientifici Maugeri IRCCS, Operative Unit for Recovery and Functional Rehabilitation of the Institute of Lumezzane, Via G. Mazzini 129, Lumezzane, Brescia, Italy.
Journal:Aging Clin Exp Res. 2022 Jan;34(1):193-199. doi: 10.1007/s40520-021-01910-2. Epub 2021 Jul 14.

15:Redefining distal symmetrical polyneuropathy features in type 1 diabetes: a systematic review.
Authors:Galosi E, Hu X, Michael N, Nyengaard JR, Truini A, Karlsson P
Institution:Department of Human Neuroscience, Sapienza University, Rome, Italy. Core Center for Molecular Morphology, Section for Stereology and Microscopy, Aarhus University, Aarhus, Denmark.
Journal:Acta Diabetol. 2022 Jan;59(1):1-19. doi: 10.1007/s00592-021-01767-x. Epub 2021 Jul 2.

16:Surgery Versus Nonsurgical Methods in Treating Neuropathic Plantar Forefoot Ulcers: A Meta-Analysis of Comparative Studies.
Authors:Yammine K, Assi C
Institution:The Diabetic Foot Clinic, Lebanese American University Medical Center-Rizk Hospital, Beirut, Lebanon.
Journal:Int J Low Extrem Wounds. 2022 Mar;21(1):7-17. doi: 10.1177/1534734620923425. Epub 2020 Jun 11.

17:Acupuncture for chemotherapy-induced peripheral neuropathy: a randomised controlled pilot study.
Authors:D'Alessandro EG, Nebuloni Nagy DR, de Brito CMM, Almeida EPM, Battistella LR, Cecatto RB
Institution:Instituto do Cancer, Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, Brasil. Rehabilitation Department, Instituto do Cancer, Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, Brazil
Journal:BMJ Support Palliat Care. 2022 Mar;12(1):64-72. doi: 10.1136/bmjspcare-2018-001542. Epub 2019 Jun 29.

For a FREE PREVIEW of the Medifocus Guidebook on Peripheral Neuropathy click here

To purchase a copy of the COMPLETE Medifocus Guidebook on Peripheral Neuropathy click here

To subscribe to additional FREE Medifocus Digest Alert on other disease/condition areas click here

Get the Medifocus Guidebook on Peripheral Neuropathy...
at a Special 20% Discount

Medifocus Guidebook on Peripheral Neuropathy

Updated: January 4, 2022
180 Pages

This one of a kind Guidebook offers:

  • Answers to your critical health questions including the latest treatments, clinical trials, and expert research.
  • High Quality, Professional level information you can trust and understand culled from the latest peer-reviewed journals.
  • Timely, up to date content with free guidebook updates for 1 year.
  • A unique resource to find leading experts, institutions, and support organizations including contact information and hyperlinks.
  • Over 130,000 Guidebooks Sold
  • 100% Risk Free Money Back Guarantee


The Medifocus Guidebook on Peripheral Neuropathy is available in the following two convenient formats:


Soft-cover book that is available for immediate shipping via either U.S. Priority Mail or International AirMail (outside the U.S.).

  • Regular List Price = $49.95
  • Less 20% Discount = - $10.00
  • Discounted Price = $39.95(excluding shipping & handling)

Order the Printed Guidebook


Available for immediate download as a PDF document.

  • Regular List Price = $34.95
  • Less 20% Discount = - $7.00
  • Discounted Price = $27.95

Order the Digital Guidebook

Order by Phone

Call Toll Free in the U.S.

From Outside the U.S.

You can also receive a 20% discount when you order your Guidebook by phone.

To receive your 20% discount, simply mention the Discount Coupon Code below to the customer service representative taking your order.

Discount Coupon Code for
Phone Orders


Coupon Expires: December 30, 2022

What Our Customers Are Saying...

"This is the BEST informational and reference book pertaining to my long-time ailment 'Peripheral Neuropathy'. I have researched this relatively obscure subject for seven years. The MediFocus Guidebook on Peripheral Neuropathy is easy reading, concise, and contains great references."
Bellevue, Nebraska

"Your very informative Guidebook helped me understand my Peripheral Neuropathy much better than my doctor had time to explain. Thank you."
Midland, Texas

"I recently purchased your MediFocus Guidebook on Peripheral Neuropathy and found the information quite helpful in making decisions about the direction I wanted to take in dealing with my condition. Even after meeting with a Neurologist and being tested, I had many questions that he was unable to answer. We all have to take control of our own health care and the MediFocus Guidebook is a great tool for doing that."
Seattle, Washington

Medifocus Digest Alert is published by Medifocus, Inc.
3809 Clarks Lane, Suite 100, Baltimore, MD 21215 USA
Copyright © 2022 Medifocus, Inc. All rights reserved.