Ductal Carcinoma in Situ of the Breast
June 2018 Issue
 
 
 

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Ductal Carcinoma in Situ of the Breast abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Ductal Carcinoma in Situ of the Breast. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Ductal Carcinoma in Situ of the Breast. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Ductal Carcinoma in Situ of the Breast every 3 months. Thank you for your ongoing subscription to this publication.

Elliot Jacob, Ph.D.
Vice-President - Content
Medifocus.com, Inc.



1:Controversies Regarding the Diagnosis and Management of Ductal Carcinoma In Situ.
Authors:Levinsohn E, Altman M, Chagpar AB
Journal:Am Surg. 2018 Jan 1;84(1):1-6.

2:Risk factors for the development of invasive cancer in unresected ductal carcinoma in situ.
Authors:Maxwell AJ, Clements K, Hilton B, Dodwell DJ, Evans A, Kearins O, Pinder SE, Thomas J, Wallis MG, Thompson AM
Institution:Nightingale Centre, Wythenshawe Hospital, Manchester, M23 9LT, UK; Division of Informatics, Imaging & Data Sciences, School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, M13 9PT, UK. Electronic address: anthony.maxwell@manchester.ac.uk.; Screening Quality Assurance Service (Midlands and East), Public Health England, 1st Floor, 5 St Philip's Place, Birmingham, B3 2PW, UK. Electronic address: karen.clements@phe.gov.uk.; Screening Quality Assurance Service (Midlands and East), Public Health England, 1st Floor, 5 St Philip's Place, Birmingham, B3 2PW, UK. Electronic address: bridget.hilton@phe.gov.uk.; Nuffield Department of Population Health, University of Oxford, Richard Doll Building, Old Road Campus, Oxford, OX3 7LF, UK. Electronic address: david.dodwell@nhs.net.; Ninewells Hospital and Medical School, Mailbox 4, Level 6, Dundee, DD1 9SY, UK. Electronic address: a.z.evans@dundee.ac.uk.
Journal:Eur J Surg Oncol. 2018 Apr;44(4):429-435. doi: 10.1016/j.ejso.2017.12.007. Epub 2018 Jan 11.

3:Is DCIS Overrated?
Authors:Feinberg J, Wetstone R, Greenstein D, Borgen P
Institution:Department of Surgery, Maimonides Breast Center, Maimonides Medical Center, Research Fellow, Oxford University, Oxford, England. PBorgen@maimonidesmed.org.
Journal:Cancer Treat Res. 2018;173:53-72. doi: 10.1007/978-3-319-70197-4_5.

4:Hypofractionated volumetric modulated arc therapy in ductal carcinoma in situ: toxicity and cosmetic outcome from a prospective series.
Authors:De Rose F, Fogliata A, Franceschini D, Iftode C, Torrisi R, Masci G, Sagona A, Tinterri C, Testori A, Gatzemeier W, Fernandes B, Rahal D, Cozzi L, Santoro A, Scorsetti M
Institution:1 Department of Radiotherapy and Radiosurgery, Humanitas Research Hospital and Cancer Center , Milan, Rozzano , Italy.; 2 Department of Medical Oncology, Humanitas Research Hospital and Cancer Center , Milan, Rozzano , Italy.; 3 Department of Breast Surgery, Humanitas Research Hospital and Cancer Center , Milan, Rozzano , Italy.; 4 Department of Pathology, Humanitas Research Hospital and Cancer Center , Milan, Rozzano , Italy.; 5 Department of Biomedical Sciences, Humanitas University , Milan, Rozzano , Italy.
Journal:Br J Radiol. 2018 May;91(1085):20170634. doi: 10.1259/bjr.20170634. Epub 2018 Mar 20.

5:Breast conserving surgery for extensive DCIS using multiple radioactive seeds.
Authors:Janssen NNY, van la Parra RFD, Loo CE, Groen EJ, van den Berg MJ, Oldenburg HSA, Nijkamp J, Vrancken Peeters MTFD
Institution:Department of Radiation Oncology, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands. Netherlands. Netherlands. Netherlands. Hospital, Amsterdam, The Netherlands. Netherlands. Netherlands. Netherlands. Electronic address: m.vrancken@nki.nl.
Journal:Eur J Surg Oncol. 2018 Jan;44(1):67-73. doi: 10.1016/j.ejso.2017.11.002. Epub 2017 Nov 20.

6:The impact of preoperative magnetic resonance imaging and lumpectomy cavity shavings on re-excision rate in pure ductal carcinoma in situ-A single institution's experience.
Authors:So A, De La Cruz LM, Williams AD, Bahng J, Liao G, McDonald ES, Fisher CS, Czerniecki BJ, Sataloff D, Tchou J
Institution:Department of Surgery, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania. Pennsylvania, Philadelphia, Pennsylvania. Pennsylvania, Philadelphia, Pennsylvania. Pennsylvania, Philadelphia, Pennsylvania. Pennsylvania, Philadelphia, Pennsylvania. Indiana. Pennsylvania, Philadelphia, Pennsylvania. Pennsylvania, Philadelphia, Pennsylvania.
Journal:J Surg Oncol. 2018 Mar;117(4):558-566. doi: 10.1002/jso.24890. Epub 2017 Nov 11.

7:Detection Rates of Ductal Carcinoma in Situ with Biennial Digital Mammography Screening: Radiologic Findings Support Pathologic Model of Tumor Progression.
Authors:Weigel S, Khil L, Hense HW, Decker T, Wellmann J, Heidrich J, Sommer A, Heidinger O, Heindel W
Institution:From the Institute of Clinical Radiology and Reference Center for Mammography (S.W., T.D., A.S., W.H.) and Institute of Epidemiology and Social Medicine (H.W.H., J.W.), University of Muenster, Albert-Schweitzer-Campus 1, 48149 Muenster, Germany; Cancer Registry of North Rhine-Westphalia, Muenster, Germany (L.K., H.W.H., J.H., O.H.); and Institute of Surgical Pathology, Dietrich Bonhoeffer-Klinikum, Neubrandenburg, Germany (T.D.).
Journal:Radiology. 2018 Feb;286(2):424-432. doi: 10.1148/radiol.2017170673. Epub 2017 Nov 6.

8:Modern Approaches to the Surgical Management of Malignant Breast Disease: The Role of Breast Conservation, Complete Mastectomy, Skin- and Nipple-Sparing Mastectomy.
Authors:Cil TD, McCready D
Institution:Department of Surgery, University of Toronto, Women's College Hospital, Room 8331, 76 Grenville Street, Toronto, Ontario M5S 1B2, Canada. Electronic address: tulin.cil@wchospital.ca. University Health Network, Room 3-130, 610 University Avenue, Toronto, Ontario M5G2M9, Canada.
Journal:Clin Plast Surg. 2018 Jan;45(1):1-11. doi: 10.1016/j.cps.2017.07.002. Epub 2017 Oct 5.

9:Minimal Clinical Impact of Intraoperative Examination of Sentinel Lymph Nodes in Patients With Ductal Carcinoma In Situ: An Opportunity for Improved Resource Utilization.
Authors:Shin ET, Joehlin-Price AS, Agnese DM, Zynger DL
Institution:Departments of Pathology.
Journal:Am J Clin Pathol. 2017 Nov 2;148(5):374-379. doi: 10.1093/ajcp/aqx089.

10:Impact of MRI on high grade Ductal Carcinoma Insitu (HG DCIS) management, are we using the full scope of MRI?
Authors:Hajaj M, Karim A, Pascaline S, Noor L, Patel S, Dakka M
Institution:Glenfield Hospital, University Hospitals of Leicester, Groby Road, Leicester LE3 9QP, United Kingdom. Electronic address: Mohamad.hajaj@nhs.net. Birmingham B9 5SS, United Kingdom. Electronic address: Ahmedkarim101@yahoo.com. United Kingdom. Electronic address: Sana.pascaline@kgh.nhs.uk. United Kingdom. Electronic address: Lubna.noor@nhs.net. 9QP, United Kingdom. Electronic address: Shivali.patel@nhs.net. Nottinghamshire, NG17 4JL. Electronic address: mdakka@icloud.com.
Journal:Eur J Radiol. 2017 Oct;95:271-277. doi: 10.1016/j.ejrad.2017.08.027. Epub 2017 Aug 31.

11:Optimal Duration of Extended Adjuvant Endocrine Therapy for Early Breast Cancer; Results of the IDEAL Trial (BOOG 2006-05).
Authors:Blok EJ, Kroep JR, Meershoek-Klein Kranenbarg E, Duijm-de Carpentier M, Putter H, van den Bosch J, Maartense E, van Leeuwen-Stok AE, Liefers GJ, Nortier JWR, Rutgers EJT, van de Velde CJH
Institution:Departments of Surgery, Medical Oncology, and Medical Statistics, Leiden University Medical Center, Leiden, Netherlands; Department of Internal Medicine, Albert Schweitzer Hospital, Dordrecht, the Netherlands; Department of Internal Medicine, Reinier de Graaff Hospital, Delft, the Netherlands; Dutch Breast Cancer Research Group, Amsterdam, the Netherlands; Department of Surgery, Netherlands Cancer Institute, Amsterdam, the Netherlands.
Journal:J Natl Cancer Inst. 2018 Jan 1;110(1). pii: 4093022. doi: 10.1093/jnci/djx134.

12:Trends in adjuvant therapies after breast-conserving surgery for hormone receptor-positive ductal carcinoma in situ: findings from the National Cancer Database, 2004-2013.
Authors:Sagara Y, Freedman RA, Wong SM, Aydogan F, Nguyen A, Barry WT, Golshan M
Institution:Department of Surgery, Brigham and Women's Hospital, Boston, MA, USA. Istanbul, Turkey. Institute, Boston, MA, USA. mgolshan@bwh.harvard.edu. 02215, USA. mgolshan@bwh.harvard.edu.
Journal:Breast Cancer Res Treat. 2017 Nov;166(2):583-592. doi: 10.1007/s10549-017-4436-9. Epub 2017 Aug 3.

13:Radiotherapy for ductal carcinoma in situ and risk of second non-breast cancers.
Authors:Withrow DR, Morton LM, Curtis RE, Schonfeld SJ, Berrington de Gonzalez A
Institution:Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA. diana.withrow@nih.gov.
Journal:Breast Cancer Res Treat. 2017 Nov;166(1):299-306. doi: 10.1007/s10549-017-4410-6. Epub 2017 Jul 25.

14:Incidence and treatments of DCIS in octogenarians: grade matters.
Authors:Ward EP, Weiss A, Blair SL
Institution:Moores Cancer Center, University of California, 3855 Heath Science Dr, MC 0987, La Jolla, San Diego, CA, 92093-0987, USA. La Jolla, San Diego, CA, 92093-0987, USA. slblair@ucsd.edu.
Journal:Breast Cancer Res Treat. 2017 Sep;165(2):403-409. doi: 10.1007/s10549-017-4330-5. Epub 2017 Jun 12.

15:Can Occult Invasive Disease in Ductal Carcinoma In Situ Be Predicted Using Computer-extracted Mammographic Features?
Authors:Shi B, Grimm LJ, Mazurowski MA, Baker JA, Marks JR, King LM, Maley CC, Hwang ES, Lo JY
Institution:Carl E. Ravin Advanced Imaging Laboratories, Department of Radiology, Duke University School of Medicine, 2424 Erwin Rd, Suite 302, Durham, NC 27705. Electronic address: bibo.shi@duke.edu.; Department of Radiology, Duke University School of Medicine, Durham, North Carolina.; Department of Surgery, Duke University School of Medicine, Durham, North Carolina.; Biodesign Center for Personalized Diagnostics and School of Life Sciences, Arizona State University, Tempe, Arizona; Centre for Evolution and Cancer, Institute of Cancer Research, London, United Kingdom.
Journal:Acad Radiol. 2017 Sep;24(9):1139-1147. doi: 10.1016/j.acra.2017.03.013. Epub 2017 May 11.

16:Treatment decision-making in ductal carcinoma in situ: A mixed methods systematic review of women's experiences and information needs.
Authors:Rutherford C, Mercieca-Bebber R, Butow P, Wu JL, King MT
Institution:School of Psychology, University of Sydney, NSW, 2006, Australia; Psycho-Oncology Co-operative Group (PoCoG), University of Sydney, NSW, 2006, Australia. Electronic address: claudia.rutherford@sydney.edu.au.; School of Psychology, University of Sydney, NSW, 2006, Australia; Psycho-Oncology Co-operative Group (PoCoG), University of Sydney, NSW, 2006, Australia; Central Clinical School, Sydney Medical School, University of Sydney, NSW, 2006, Australia.; School of Psychology, University of Sydney, NSW, 2006, Australia.
Journal:Patient Educ Couns. 2017 Sep;100(9):1654-1666. doi: 10.1016/j.pec.2017.04.009. Epub 2017 Apr 15.

17:What quality-of-life issues do women with ductal carcinoma in situ (DCIS) consider important when making treatment decisions?
Authors:Mercieca-Bebber R, King MT, Boxer MM, Spillane A, Winters ZE, Butow PN, McPherson J, Rutherford C
Institution:Central Clinical School, Sydney Medical School, University of Sydney, Camperdown, NSW, Australia. Rebecca.mercieca@sydney.edu.au.; Quality of Life Office, Psycho-oncology Co-operative Research Group, School of Psychology, University of Sydney, Level 6 North, Lifehouse (C39Z), Sydney, NSW, 2006, Australia. Rebecca.mercieca@sydney.edu.au.; Liverpool Cancer Therapy Centre, Liverpool Hospital, Liverpool, NSW, Australia.; South Western Sydney Clinical School, University of New South Wales, Sydney, NSW, Australia.; Northern Clinical School, Sydney Medical School, University of Sydney, Sydney, NSW, Australia.
Journal:Breast Cancer. 2017 Sep;24(5):720-729. doi: 10.1007/s12282-017-0765-0. Epub 2017 Feb 28.

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