Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.
Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Glioblastoma abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Glioblastoma. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Glioblastoma. You can access the summaries of each article referenced below by simply clicking on the article Title.
We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Glioblastoma every 3 months. Thank you for your ongoing subscription to this publication.
Elliot Jacob, Ph.D.
Vice-President - Content
|Authors:||Stupp R, Taillibert S, Kanner A, Read W, Steinberg DM, Lhermitte B, Toms S, Idbaih A, Ahluwalia MS, Fink K, Di Meco F, Lieberman F, Zhu JJ, Stragliotto G, Tran DD, Brem S, Hottinger AF, Kirson ED, Lavy-Shahaf G, Weinberg U, Kim CY, Paek SH, Nicholas G, Burna J, Hirte H, Weller M, Palti Y, Hegi ME, Ram Z|
|Institution:||Lou and Jean MalnatiBrain Tumor Institute of the Robert H. Lurie Comprehensive Cancer Center of Northwestern University Feinberg School of Medicine, Chicago, Illinois. Switzerland. 1127, Institut du Cerveau et de la Moelle epiniere, ICM, F-75013, Paris, France. Switzerland. 1127, Institut du Cerveau et de la Moelle epiniere, ICM, F-75013, Paris, France. Switzerland. Medicine, Bundang, Korea. Switzerland.|
|Journal:||JAMA. 2017 Dec 19;318(23):2306-2316. doi: 10.1001/jama.2017.18718.|
|Authors:||Park MN, Song HS, Kim M, Lee MJ, Cho W, Lee HJ, Hwang CH, Kim S, Hwang Y, Kang B, Kim B|
|Institution:||College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea. School, Kyung Hee University, Seoul, Republic of Korea.|
|Journal:||Biomed Res Int. 2017;2017:8139848. doi: 10.1155/2017/8139848. Epub 2017 Oct 18.|
|Authors:||Wick W, Gorlia T, Bendszus M, Taphoorn M, Sahm F, Harting I, Brandes AA, Taal W, Domont J, Idbaih A, Campone M, Clement PM, Stupp R, Fabbro M, Le Rhun E, Dubois F, Weller M, von Deimling A, Golfinopoulos V, Bromberg JC, Platten M, Klein M, van den Bent MJ|
|Institution:||From the University Medical Center and German Cancer Research Center, Heidelberg, Germany (W.W., M.B., F.S., I.H., A.D., M.P.); the European Organization for Research and Treatment of Cancer, Brussels (T.G., V.G.), and Leuven Cancer Institute-KU Leuven, Leuven (P.M.C.) - both in Belgium; Haaglanden Medical Center, The Hague (M.T.), Erasmus MC Cancer Institute, Rotterdam (W.T., J.C.B., M.J.B.), and VU University Medical Center, Amsterdam (M.K.) - all in the Netherlands; the Medical Oncology Department, Azienda Unita Sanitaria Locale di Bologna-IRCCS Istituto delle Scienze Neurologiche, Bologna, Italy (A.A.B.); Institut Gustave Roussy, Villejuif (J.D.), Assistance Publique-Hopitaux de Paris, Hopitaux Universitaires La Pitie Salpetriere-Charles Foix, Service de Neurologie 2-Mazarin, INSERM Unite 1127, Centre National de la Recherche Scientifique Unite Mixte de Recherche (UMR) 7225, Sorbonne Universites, University Pierre and Marie Curie 06 UMR S1127, and Institut du Cerveau et de la Moelle Epiniere, Paris (A.I.), Institut de Cancerologie de l'Ouest-Centre Rene Gauducheau, Saint-Herblain (M.C.), Institut Regional du Cancer Montpellier, Montpellier (M.F.), and Centre Hospitalier Regional Universitaire de Lille, Lille (E.L.R., F.D.) - all in France; and the Departments of Oncology and Neurology, University Hospital and University of Zurich, Zurich, Switzerland (R.S., M.W.).|
|Journal:||N Engl J Med. 2017 Nov 16;377(20):1954-1963. doi: 10.1056/NEJMoa1707358.|
|Authors:||Balana C, Capellades J, Pineda E, Estival A, Puig J, Domenech S, Verger E, Pujol T, Martinez-Garcia M, Oleaga L, Velarde J, Mesia C, Fuentes R, Marruecos J, Del Barco S, Villa S, Carrato C, Gallego O, Gil-Gil M, Craven-Bartle J, Alameda F|
|Institution:||Medical Oncology, Institut Catala Oncologia (ICO), Badalona, Barcelona, Spain. Research Institute (IDIBGI), Hospital Universitari Dr Josep Trueta, Girona, Spain. LLobregat, Barcelona, Spain. Barcelona, Spain. LLobregat, Barcelona, Spain.|
|Journal:||Cancer Med. 2017 Dec;6(12):2858-2866. doi: 10.1002/cam4.1242. Epub 2017 Nov 3.|
|Authors:||Shi W, Scannell Bryan M, Gilbert MR, Mehta MP, Blumenthal DT, Brown PD, Valeinis E, Hopkins K, Souhami L, Andrews DW, Tzuk-Shina T, Howard SP, Youssef EF, Lessard N, Dignam JJ, Werner-Wasik M|
|Institution:||Sidney Kimmel Cancer Center and Medical College at Thomas Jefferson University, Philadelphia, Pennsylvania. Illinois. Philadelphia, Pennsylvania. Foundation, Phoenix, Arizona. Illinois; NRG Oncology Statistics and Data Management Center, Philadelphia, Pennsylvania. Philadelphia, Pennsylvania. Electronic address: email@example.com.|
|Journal:||Int J Radiat Oncol Biol Phys. 2018 Jan 1;100(1):38-44. doi: 10.1016/j.ijrobp.2017.08.038. Epub 2017 Sep 4.|
|Authors:||Wang Z, Yang G, Zhang YY, Yao Y, Dong LH|
|Institution:||aDepartment of Radiotherapy, Norman Bethune First Hospital bDepartment of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, China.|
|Journal:||Medicine (Baltimore). 2017 Nov;96(44):e8444. doi: 10.1097/MD.0000000000008444.|
|Authors:||van den Bent M, Gan HK, Lassman AB, Kumthekar P, Merrell R, Butowski N, Lwin Z, Mikkelsen T, Nabors LB, Papadopoulos KP, Penas-Prado M, Simes J, Wheeler H, Walbert T, Scott AM, Gomez E, Lee HJ, Roberts-Rapp L, Xiong H, Bain E, Ansell PJ, Holen KD, Maag D, Reardon DA|
|Institution:||Brain Tumor Center, Erasmus MC Cancer Institute, Groene Hilledijk 301, 3075 EA, Rotterdam, the Netherlands. firstname.lastname@example.org. University Medical Center, New York, NY, USA. Francisco, CA, USA. Royal Brisbane and Women's Hospital, Brisbane, Australia.|
|Journal:||Cancer Chemother Pharmacol. 2017 Dec;80(6):1209-1217. doi: 10.1007/s00280-017-3451-1. Epub 2017 Oct 26.|
|Authors:||Nam JY, de Groot JF|
|Institution:||The University of Texas MD Anderson Cancer Center, Houston, TX.|
|Journal:||J Oncol Pract. 2017 Oct;13(10):629-638. doi: 10.1200/JOP.2017.025536.|
|Authors:||Nizamutdinov D, Stock EM, Dandashi JA, Vasquez EA, Mao Y, Dayawansa S, Zhang J, Wu E, Fonkem E, Huang JH|
|Institution:||Texas A&M Health Science Center College of Medicine, Temple, Texas, USA; Department of Neurosurgery, Baylor Scott and White Health Care, Temple, Texas, USA. System, Perry Point, Maryland, USA. Department of Neurosurgery, Baylor Scott and White Health Care, Temple, Texas, USA. USA. Department of Neurosurgery, Baylor Scott and White Health Care, Temple, Texas, USA. Department of Neurosurgery, Baylor Scott and White Health Care, Temple, Texas, USA. Electronic address: Jason.Huang@bswhealth.org.|
|Journal:||World Neurosurg. 2018 Jan;109:e67-e74. doi: 10.1016/j.wneu.2017.09.104. Epub 2017 Sep 23.|
|Authors:||Weller M, Butowski N, Tran DD, Recht LD, Lim M, Hirte H, Ashby L, Mechtler L, Goldlust SA, Iwamoto F, Drappatz J, O'Rourke DM, Wong M, Hamilton MG, Finocchiaro G, Perry J, Wick W, Green J, He Y, Turner CD, Yellin MJ, Keler T, Davis TA, Stupp R, Sampson JH|
|Institution:||Department of Neurology, University Hospital and University of Zurich, Zurich, Switzerland. Electronic address: email@example.com. USA. Pennsylvania, Philadelphia, PA, USA. Neurosurgery, Foothills Hospital, Calgary, AB, Canada. Germany. Switzerland. Durham, NC, USA.|
|Journal:||Lancet Oncol. 2017 Oct;18(10):1373-1385. doi: 10.1016/S1470-2045(17)30517-X. Epub 2017 Aug 23.|
|Authors:||Badruddoja MA, Pazzi M, Sanan A, Schroeder K, Kuzma K, Norton T, Scully T, Mahadevan D, Ahmadi MM|
|Institution:||Center for Neurosciences, 2450 E River Rd, Tucson, AZ, 85718, USA. firstname.lastname@example.org. Campbell Avenue, Tucson, AZ, 85724, USA. email@example.com.|
|Journal:||Cancer Chemother Pharmacol. 2017 Oct;80(4):715-721. doi: 10.1007/s00280-017-3405-7. Epub 2017 Aug 14.|
|Authors:||Miranda A, Blanco-Prieto MJ, Sousa J, Pais A, Vitorino C|
|Institution:||Faculty of Pharmacy, University of Coimbra, Portugal; Pharmacometrics Group of the Centre for Neurosciences and Cell Biology (CNC), University of Coimbra, Portugal. Electronic address: firstname.lastname@example.org.; Department of Pharmacy and Pharmaceutical Technology, School of Pharmacy, University of Navarra, Pamplona, Spain; Instituto de Investigacion Sanitaria de Navarra, IdiSNA, Pamplona, Spain.; Coimbra Chemistry Center, Department of Chemistry, University of Coimbra, Portugal.|
|Journal:||Int J Pharm. 2017 Oct 5;531(1):389-410. doi: 10.1016/j.ijpharm.2017.07.049. Epub 2017 Aug 9.|
|Authors:||Miranda A, Blanco-Prieto M, Sousa J, Pais A, Vitorino C|
|Institution:||Faculty of Pharmacy, University of Coimbra, Portugal; Pharmacometrics Group of the Centre for Neurosciences and Cell Biology (CNC), University of Coimbra, Portugal. Electronic address: email@example.com.; Department of Pharmacy and Pharmaceutical Technology, School of Pharmacy, University of Navarra, Spain.; Coimbra Chemistry Center, Department of Chemistry, University of Coimbra, Portugal.|
|Journal:||Int J Pharm. 2017 Oct 5;531(1):372-388. doi: 10.1016/j.ijpharm.2017.07.056. Epub 2017 Jul 27.|
|Authors:||Gan HK, van den Bent M, Lassman AB, Reardon DA, Scott AM|
|Institution:||Austin Health and Olivia Newton-John Cancer Research Institute, 145 Studley Road, Heidelberg, Victoria 3084, Australia. Victoria 3084, Australia. Victoria 3084, Australia. Rotterdam, Netherlands. University Medical Center, 161 Fort Washington Avenue, New York, New York 10032, USA. Massachusetts 02215, USA. Heidelberg, Victoria 3084, Australia. Victoria 3084, Australia. Victoria 3084, Australia.|
|Journal:||Nat Rev Clin Oncol. 2017 Nov;14(11):695-707. doi: 10.1038/nrclinonc.2017.95. Epub 2017 Jul 4.|
|Authors:||Nakagawa Y, Sasaki H, Ohara K, Ezaki T, Toda M, Ohira T, Kawase T, Yoshida K|
|Institution:||Department of Neurosurgery, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan. Electronic address: firstname.lastname@example.org.; Department of Pathology, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.|
|Journal:||World Neurosurg. 2017 Oct;106:165-173. doi: 10.1016/j.wneu.2017.06.126. Epub 2017 Jun 27.|
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What Our Customers Are Saying...
"To be diagnosed with a glioblastoma is devastating news. The MediFocus Guidebook on Glioblastoma clearly explained medical terms and adopted a positive approach although not discounting the problems."
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