Scleroderma
April 2017 Issue
 
 
 

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Scleroderma abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Scleroderma. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Scleroderma. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Scleroderma every 3 months. Thank you for your ongoing subscription to this publication.

Sincerely,
Elliot Jacob, Ph.D.
Vice-President - Content
Medifocus.com, Inc.



1:Occupational and environmental scleroderma. Systematic review and meta-analysis.
Authors:Rubio-Rivas M, Moreno R, Corbella X
Institution:Autoimmune Diseases Unit. Department of Internal Medicine, Bellvitge University Hospital-IDIBELL. L'Hospitalet de Llobregat, Feixa Llarga s/n, Hospitalet de Llobregat, Barcelona, Spain. mrubio@bellvitgehospital.cat. Hospital-IDIBELL. L'Hospitalet de Llobregat, Feixa Llarga s/n, Hospitalet de Llobregat, Barcelona, Spain. Hospital-IDIBELL. L'Hospitalet de Llobregat, Feixa Llarga s/n, Hospitalet de Llobregat, Barcelona, Spain. Barcelona, Spain.
Journal:Clin Rheumatol. 2017 Mar;36(3):569-582. doi: 10.1007/s10067-016-3533-1. Epub 2017 Jan 14.

2:Serum 25-OH vitamin D levels in systemic sclerosis: analysis of 140 patients and review of the literature.
Authors:Giuggioli D, Colaci M, Cassone G, Fallahi P, Lumetti F, Spinella A, Campomori F, Manfredi A, Manzini CU, Antonelli A, Ferri C
Institution:Rheumatology Unit, Department of Internal Medicine, University of Modena and Reggio Emilia, Via del Pozzo, 71, 41100, Modena, Italy. diliagiuggioli@hotmail.com. Reggio Emilia, Via del Pozzo, 71, 41100, Modena, Italy. Reggio Emilia, Via del Pozzo, 71, 41100, Modena, Italy. Reggio Emilia, Via del Pozzo, 71, 41100, Modena, Italy. Italy. Reggio Emilia, Via del Pozzo, 71, 41100, Modena, Italy. Reggio Emilia, Via del Pozzo, 71, 41100, Modena, Italy. Reggio Emilia, Via del Pozzo, 71, 41100, Modena, Italy. Reggio Emilia, Via del Pozzo, 71, 41100, Modena, Italy. Reggio Emilia, Via del Pozzo, 71, 41100, Modena, Italy. Reggio Emilia, Via del Pozzo, 71, 41100, Modena, Italy. Italy. Reggio Emilia, Via del Pozzo, 71, 41100, Modena, Italy.
Journal:Clin Rheumatol. 2017 Mar;36(3):583-590. doi: 10.1007/s10067-016-3535-z. Epub 2017 Jan 9.

3:Genomic and genetic studies of systemic sclerosis: A systematic review.
Authors:Chairta P, Nicolaou P, Christodoulou K
Institution:Neurogenetics Department, The Cyprus Institute of Neurology and Genetics, Nicosia 2370, Cyprus; Cyprus School of Molecular Medicine, The Cyprus Institute of Neurology and Genetics, Nicosia 2370, Cyprus. 2370, Cyprus; Cyprus School of Molecular Medicine, The Cyprus Institute of Neurology and Genetics, Nicosia 2370, Cyprus. 2370, Cyprus; Cyprus School of Molecular Medicine, The Cyprus Institute of Neurology and Genetics, Nicosia 2370, Cyprus. Electronic address: roula@cing.ac.cy.
Journal:Hum Immunol. 2017 Feb;78(2):153-165. doi: 10.1016/j.humimm.2016.10.017. Epub 2016 Oct 29.

4:UK Scleroderma Study Group (UKSSG) guidelines on the diagnosis and management of scleroderma renal crisis.
Authors:Lynch BM, Stern EP, Ong V, Harber M, Burns A, Denton CP
Institution:Centre for Rheumatology, Royal Free London and UCL Division of Medicine, London, UK. UK. UK. UK. c.denton@ucl.ac.uk.
Journal:Clin Exp Rheumatol. 2016 Sep-Oct;34 Suppl 100(5):106-109. Epub 2016 Sep 29.

5:Fractional carbon dioxide laser versus low-dose UVA-1 phototherapy for treatment of localized scleroderma: a clinical and immunohistochemical randomized controlled study.
Authors:Shalaby SM, Bosseila M, Fawzy MM, Abdel Halim DM, Sayed SS, Allam RS
Institution:Department of Dermatology, Faculty of Medicine, Cairo University, Cairo, Egypt.
Journal:Lasers Med Sci. 2016 Nov;31(8):1707-1715. Epub 2016 Aug 10.

6:Pulmonary involvement in systemic sclerosis.
Authors:Morales-Cardenas A, Perez-Madrid C, Arias L, Ojeda P, Mahecha MP, Rojas-Villarraga A, Carrillo-Bayona JA, Anaya JM
Institution:Center for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Carrera 24 No. 63-C-69, Bogota, Colombia. Electronic address: juan.anaya@urosario.edu.co.; Mederi, Hospital Universitario Mayor, Calle 24 No. 29-45, Bogota, Colombia.; Hospital Santa Clara ESE, CRA 14 B No. 1-45 Sur, Bogota, Colombia.
Journal:Autoimmun Rev. 2016 Nov;15(11):1094-1108. doi: 10.1016/j.autrev.2016.07.025. Epub 2016 Aug 4.

7:One year in review 2016: systemic sclerosis.
Authors:Barsotti S, Stagnaro C, d'Ascanio A, Della Rossa A
Institution:Rheumatology Unit, University of Pisa; and Department of Medical Biotechnologies, University of Siena, Italy. simone.barsotti.pisa@gmail.com.
Journal:Clin Exp Rheumatol. 2016 Sep-Oct;34 Suppl 100(5):3-13. Epub 2016 Jul 18.

8:Localized scleroderma en coup de sabre in the Neurology Clinic.
Authors:Pinho J, Rocha J, Sousa F, Macedo C, Soares-Fernandes J, Cerqueira J, Mare R, Lourenco E, Pereira J
Institution:Neurology Department, Hospital de Braga, Portugal. 4715-196 Braga, Portugal. Electronic address: joaomrocha@gmail.com. Life and Health Sciences Research Institute (ICVS), University of Minho, Portugal.
Journal:Mult Scler Relat Disord. 2016 Jul;8:96-8. doi: 10.1016/j.msard.2016.05.013. Epub 2016 May 20.

9:A case report: The efficacy of pirfenidone in a Chinese patient with progressive systemic sclerosis-associated interstitial lung disease: A CARE-compliant article.
Authors:Huang H, Feng RE, Li S, Xu K, Bi YL, Xu ZJ
Institution:aDepartment of Respiratory Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College bPathological Department, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College cRadiological Department, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Dongcheng, Beijing, China.
Journal:Medicine (Baltimore). 2016 Jul;95(27):e4113. doi: 10.1097/MD.0000000000004113.

10:Disease activity indices in systemic sclerosis: a systematic literature review.
Authors:Melsens K, De Keyser F, Decuman S, Piette Y, Vandecasteele E, Smith V
Institution:Department of Internal Medicine, Faculty of Medicine and Health Sciences, Ghent University, Belgium. karin.melsens@ugent.be. University; and Department of Rheumatology, Faculty of Medicine and Health Sciences, Ghent University, Belgium. University, Belgium. University, Belgium. University; and Department of Rheumatology, Faculty of Medicine and Health Sciences, Ghent University, Belgium.
Journal:Clin Exp Rheumatol. 2016 Sep-Oct;34 Suppl 100(5):186-192. Epub 2016 Jul 6.

11:Systemic sclerosis: rehabilitation as a tool to cope with disability.
Authors:Maddali-Bongi S, Del Rosso A
Institution:Division of Rheumatology, Department of Clinical and Experimental Medicine, University of Florence, Italy. University of Florence, Italy.
Journal:Clin Exp Rheumatol. 2016 Sep-Oct;34 Suppl 100(5):162-169. Epub 2016 Jul 4.

12:One decade distinct features, morbidity and mortality of scleroderma: a cross-sectional study.
Authors:Nazarinia MA, Esmaeilzadeh E, Emami Y, Salehi A
Institution:Shiraz Geriatric Research Centre, Shiraz University of Medical Sciences, Shiraz, Iran.
Journal:Clin Exp Rheumatol. 2016 Sep-Oct;34 Suppl 100(5):74-78. Epub 2016 Jun 15.

13:Safety and efficacy of subcutaneous tocilizumab in adults with systemic sclerosis (faSScinate): a phase 2, randomised, controlled trial.
Authors:Khanna D, Denton CP, Jahreis A, van Laar JM, Frech TM, Anderson ME, Baron M, Chung L, Fierlbeck G, Lakshminarayanan S, Allanore Y, Pope JE, Riemekasten G, Steen V, Muller-Ladner U, Lafyatis R, Stifano G, Spotswood H, Chen-Harris H, Dziadek S, Morimoto A, Sornasse T, Siegel J, Furst DE
Institution:University of Michigan Scleroderma Program, Ann Arbor, MI, USA. Electronic address: khannad@med.umich.edu. Alto, CA, USA. ON, Canada.
Journal:Lancet. 2016 Jun 25;387(10038):2630-40. doi: 10.1016/S0140-6736(16)00232-4. Epub 2016 May 5.

14:Current and future direction in the management of scleroderma.
Authors:Brady SM, Shapiro L, Mousa SA
Institution:The Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, 1 Discovery Drive (Room 238), Rensselaer, NY, 12144, USA. Albany, NY, USA. Sciences, 1 Discovery Drive (Room 238), Rensselaer, NY, 12144, USA. shaker.mousa@acphs.edu.
Journal:Arch Dermatol Res. 2016 Sep;308(7):461-71. doi: 10.1007/s00403-016-1647-6. Epub 2016 Apr 30.

15:Risk factors for malignancy in systemic sclerosis patients.
Authors:Kasifoglu T, Yasar Bilge S, Yildiz F, Ozen G, Pehlivan Y, Yilmaz N, Tarhan F, Yilmaz S, Kucuk A, Emmungil H, Koca SS, Cinar M, Direskeneli H, Erken E, Can G, Ozmen M, Gonullu E, Kisacik B, Aksu K, Karadag O, Kasifoglu N, Arslantas D, Sahin F, Keser G, Yavuz S, Birlik M, Onat AM
Institution:Department of Internal Medicine, Division of Rheumatology, Eskisehir Osmangazi University School of Medicine, Sumer Mahallesi, Atali Sokak 4/2, 26400, Eskisehir, Turkey. University School of Medicine, Sumer Mahallesi, Atali Sokak 4/2, 26400, Eskisehir, Turkey. suleyasar@yahoo.com. School of Medicine, Adana, Turkey. School of Medicine, Istanbul, Turkey. School of Medicine, Gaziantep, Turkey. University School of Medicine, Istanbul, Turkey. University School of Medicine, Izmir, Turkey. Medical School of Medicine, Konya, Turkey. University School of Medicine, Konya, Turkey. of Medicine, Izmir, Turkey. School of Medicine, Elazig, Turkey. School of Medicine, Istanbul, Turkey. School of Medicine, Istanbul, Turkey. School of Medicine, Adana, Turkey. University School of Medicine, Izmir, Turkey. University School of Medicine, Izmir, Turkey. University School of Medicine, Sumer Mahallesi, Atali Sokak 4/2, 26400, Eskisehir, Turkey. School of Medicine, Gaziantep, Turkey. of Medicine, Izmir, Turkey. School of Medicine, Ankara, Turkey. Eskisehir, Turkey. Eskisehir, Turkey. Eskisehir, Turkey. of Medicine, Izmir, Turkey. University School of Medicine, Istanbul, Turkey. School of Medicine, Izmir, Turkey. School of Medicine, Gaziantep, Turkey.
Journal:Clin Rheumatol. 2016 Jun;35(6):1529-33. doi: 10.1007/s10067-016-3288-8. Epub 2016 Apr 27.

16:Survival and causes of death in systemic sclerosis patients: a single center registry report from Iran.
Authors:Poormoghim H, Andalib E, Jalali A, Ghaderi A, Ghorbannia A, Mojtabavi N
Institution:Scleroderma Study Group, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran. poormoghim.h@iums.ac.ir. Sciences, Tehran, Iran. Tehran, Iran. Tehran, Iran.
Journal:Rheumatol Int. 2016 Jul;36(7):925-34. doi: 10.1007/s00296-016-3475-6. Epub 2016 Apr 9.

17:Mycophenolate mofetil is an effective and safe option for the management of systemic sclerosis-associated interstitial lung disease: results from the Australian Scleroderma Cohort Study.
Authors:Owen C, Ngian GS, Elford K, Moore O, Stevens W, Nikpour M, Rabusa C, Proudman S, Roddy J, Zochling J, Hill C, Sturgess A, Tymms K, Youssef P, Sahhar J
Institution:Department of Rheumatology, Monash Health, Clayton VIC, Australia. Parkville VIC, Australia. University of Adelaide, SA, Australia. Medicine, University of Adelaide, SA, Australia. of Medicine, Monash University, Clayton, VIC, Australia. josahhar@bigpond.com.
Journal:Clin Exp Rheumatol. 2016 Sep-Oct;34 Suppl 100(5):170-176. Epub 2016 Mar 24.

18:Drug Survival and Predictors of Drug Survival for Methotrexate Treatment in a Retrospective Cohort of Adult Patients with Localized Scleroderma.
Authors:Mertens JS, van den Reek JM, Kievit W, van de Kerkhof PC, Thurlings RM, Radstake TR, Seyger MM, de Jong EM
Institution:Department of Dermatology, Radboud University Medical Center, 6525 GL Nijmegen, The Netherlands. Jorre.Mertens@radboudumc.nl.
Journal:Acta Derm Venereol. 2016 Nov 2;96(7):943-947. doi: 10.2340/00015555-2411.

19:A successful case of second autologous haematopoietic stem cell transplantation for post-transplant systemic sclerosis relapse.
Authors:Hou Y, Li HJ, Li MT, Xu D, Zhou DB, Zeng XF
Institution:Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. of Medical Sciences & Peking Union Medical College, Beijing, China. Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Journal:Clin Exp Rheumatol. 2016 Sep-Oct;34 Suppl 100(5):207. Epub 2016 Feb 9.

20:Efficacy of cilostazol for the treatment of Raynaud's phenomenon in systemic sclerosis patients.
Authors:Negrini S, Spano F, Penza E, Rollando D, Indiveri F, Filaci G, Puppo F
Institution:Department of Internal Medicine, Clinical Immunology Unit, University of Genoa, 16132, Genoa, Italy. negrini@unige.it. Italy. negrini@unige.it. 16132, Genoa, Italy. 16132, Genoa, Italy. 16132, Genoa, Italy. 16132, Genoa, Italy. Italy. 16132, Genoa, Italy.
Journal:Clin Exp Med. 2016 Aug;16(3):407-12. doi: 10.1007/s10238-015-0370-5. Epub 2015 Jun 19.

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