Scleroderma
February 2018 Issue
 
 
 

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Scleroderma abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Scleroderma. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Scleroderma. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Scleroderma every 3 months. Thank you for your ongoing subscription to this publication.

Sincerely,
Elliot Jacob, Ph.D.
Vice-President - Content
Medifocus.com, Inc.



1:Myeloablative Autologous Stem-Cell Transplantation for Severe Scleroderma.
Authors:Sullivan KM, Goldmuntz EA, Keyes-Elstein L, McSweeney PA, Pinckney A, Welch B, Mayes MD, Nash RA, Crofford LJ, Eggleston B, Castina S, Griffith LM, Goldstein JS, Wallace D, Craciunescu O, Khanna D, Folz RJ, Goldin J, St Clair EW, Seibold JR, Phillips K, Mineishi S, Simms RW, Ballen K, Wener MH, Georges GE, Heimfeld S, Hosing C, Forman S, Kafaja S, Silver RM, Griffing L, Storek J, LeClercq S, Brasington R, Csuka ME, Bredeson C, Keever-Taylor C, Domsic RT, Kahaleh MB, Medsger T, Furst DE
Institution:From the Duke University Medical Center (K.M.S., O.C., E.W.S.C.) and RTI International (D.W.), Durham, and Rho Federal Systems Division, Chapel Hill (L.K.-E., A.P., B.E., S.C.) - all in North Carolina; National Institute of Allergy and Infectious Diseases, Bethesda, MD (E.A.G., B.W., L.M.G., J.S.G.); Colorado Blood Cancer Institute, Denver (P.A.M., R.A.N.); University of Texas McGovern Medical School (M.D.M.) and M.D. Anderson Cancer Center (C.H.) - both in Houston; Vanderbilt University, Nashville (L.J.C., K.P.); University of Michigan, Ann Arbor (D.K., J.R.S.); Case Western Reserve University and University Hospitals, Cleveland (R.J.F.); University of Alabama, Birmingham (S.M.); Boston University, Boston (R.W.S.); University of Virginia, Charlottesville (K.B.); University of Washington (M.H.W., D.E.F.) and the Fred Hutchinson Cancer Research Center (G.E.G., S.H.) - both in Seattle; University of California, Los Angeles, Los Angeles (J.G., S.K., D.E.F.); City of Hope National Medical Center, Duarte, CA (S.F.); Medical University of South Carolina, Charleston (R.M.S.); Mayo Clinic, Scottsdale, AZ (L.G.); University of Calgary, Calgary, AB, Canada (J.S., S.L.); Washington University, St. Louis (R.B.); Medical College of Wisconsin, Milwaukee (M.E.C., C.K.-T.); Ottawa Hospital Research Institute, Ottawa (C.B.); University of Pittsburgh, Pittsburgh (T.M., R.T.D.); and University of Toledo Medical Center, Toledo, OH (M.B.K.).
Journal:N Engl J Med. 2018 Jan 4;378(1):35-47.

2:Efficacy and Safety of Selexipag in Adults With Raynaud's Phenomenon Secondary to Systemic Sclerosis: A Randomized, Placebo-Controlled, Phase II Study.
Authors:Denton CP, Hachulla E, Riemekasten G, Schwarting A, Frenoux JM, Frey A, Le Brun FO, Herrick AL
Institution:Royal Free Hospital, London, UK. Internal Medicine, Hopital Huriez, University of Lille, Lille, France. Kreuznach, Germany. Manchester Musculoskeletal Biomedical Research Centre, Central Manchester NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK.
Journal:Arthritis Rheumatol. 2017 Dec;69(12):2370-2379. doi: 10.1002/art.40242.

3:Work productivity in systemic sclerosis, its economic burden and association with health-related quality of life.
Authors:Morrisroe K, Sudararajan V, Stevens W, Sahhar J, Zochling J, Roddy J, Proudman S, Nikpour M
Institution:Department of Medicine, University of Melbourne at St Vincent's Hospital Melbourne. Melbourne. Tasmania. Adelaide, SA, Australia. Melbourne.
Journal:Rheumatology (Oxford). 2018 Jan 1;57(1):73-83. doi: 10.1093/rheumatology/kex362.

4:Patient acceptable symptom state in scleroderma: results from the tocilizumab compared with placebo trial in active diffuse cutaneous systemic sclerosis.
Authors:Arnold MB, Khanna D, Denton CP, van Laar JM, Frech TM, Anderson ME, Baron M, Chung L, Fierlbeck G, Lakshminarayanan S, Allanore Y, Riemekasten G, Steen V, Muller-Ladner U, Spotswood H, Burke L, Siegel J, Jahreis A, Furst DE, Pope JE
Institution:Schulich School of Medicine and Dentistry, Western University, London, ON, Canada. School, London, UK. Netherlands. City, UT, USA. UK. Health Care System, Palo Alto, CA, USA. Berlin, Germany. University Giessen, Kerckhoff Clinic, Bad Nauheim, Germany. Canada.
Journal:Rheumatology (Oxford). 2018 Jan 1;57(1):152-157. doi: 10.1093/rheumatology/kex396.

5:Factors associated with disease progression in early-diagnosed pulmonary arterial hypertension associated with systemic sclerosis: longitudinal data from the DETECT cohort.
Authors:Mihai C, Antic M, Dobrota R, Bonderman D, Chadha-Boreham H, Coghlan JG, Denton CP, Doelberg M, Grunig E, Khanna D, McLaughlin VV, Muller-Ladner U, Pope JE, Rosenberg DM, Seibold JR, Vonk MC, Distler O
Institution:Department of Internal Medicine and Rheumatology, Dr. Ion Cantacuzino Clinical Hospital, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania. Hospital, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania. Vienna, Vienna, Austria. Heidelberg, Baden-Wurttemberg, Germany. Michigan, Ann Arbor, Michigan, USA. Arbor, Michigan, USA. Giessen, Germany. London, Canada. Netherlands.
Journal:Ann Rheum Dis. 2018 Jan;77(1):128-132. doi: 10.1136/annrheumdis-2017-211480. Epub 2017 Oct 23.

6:One year in review 2017: systemic sclerosis.
Authors:Barsotti S, Bruni C, Orlandi M, Della Rossa A, Marasco E, Codullo V, Guiducci S
Institution:Department of Clinical and Experimental Medicine, Rheumatology Unit, University of Pisa; Department of Medical Biotechnologies, University of Siena, Italy. of Florence, Italy. of Florence, Italy. of Pisa, Italy. a.dellarossa@ao-pisa.toscana.it. Pavia, Italy. Pavia, Italy. of Florence, Italy.
Journal:Clin Exp Rheumatol. 2017 Sep-Oct;35 Suppl 106(4):3-20. Epub 2017 Sep 29.

7:Assessment of skin involvement in systemic sclerosis.
Authors:Kumanovics G, Pentek M, Bae S, Opris D, Khanna D, Furst DE, Czirjak L
Institution:Department of Rheumatology and Immunology, Medical School, University of Pecs, Pecs. Hungary. CA, USA. Pharmacy, Bucharest, Romania. Michigan, Ann Arbor, MI, USA. CA, USA. Pecs.
Journal:Rheumatology (Oxford). 2017 Sep 1;56(suppl_5):v53-v66. doi: 10.1093/rheumatology/kex202.

8:Points to consider in renal involvement in systemic sclerosis.
Authors:Galluccio F, Muller-Ladner U, Furst DE, Khanna D, Matucci-Cerinic M
Institution:Department of Clinical and Experimental Medicine, Division of Rheumatology, University of Florence, AOU Careggi, Florence, Italy. Giessen, Giessen. Kerckhoff-Klinik, Bad Nauheim, Germany. California, Los Angeles, Los Angeles, CA. Michigan, Ann Arbor, MI, USA. University of Florence, AOU Careggi, Florence, Italy.
Journal:Rheumatology (Oxford). 2017 Sep 1;56(suppl_5):v49-v52. doi: 10.1093/rheumatology/kex201.

9:Points to consider for skin ulcers in systemic sclerosis.
Authors:Galluccio F, Allanore Y, Czirjak L, Furst DE, Khanna D, Matucci-Cerinic M
Institution:Department of Clinical and Experimental Medicine, Division of Rheumatology, University of Florence, AOU Careggi, Florence, Italy. Publique-Hopitaux de Paris, Paris-Descartes University, Paris, France. California. Los Angeles, Los Angeles, CA. Michigan, Ann Arbor, MI, USA. University of Florence, AOU Careggi, Florence, Italy.
Journal:Rheumatology (Oxford). 2017 Sep 1;56(suppl_5):v67-v71. doi: 10.1093/rheumatology/kex200.

10:Points to consider-Raynaud's phenomenon in systemic sclerosis.
Authors:Cutolo M, Smith V, Furst DE, Khanna D, Herrick AL
Institution:Research Laboratories and Division of Clinical Rheumatology, Department of Internal Medicine, IRCCS, University of Genova, Genova, Italy. Medicine at UCLA, Los Angeles, CA. Program, Ann Arbor, MI. NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester NHS Foundation Trust, Manchester Academic Health Science Centre, UK.
Journal:Rheumatology (Oxford). 2017 Sep 1;56(suppl_5):v45-v48. doi: 10.1093/rheumatology/kex199.

11:Points to consider when doing a trial primarily involving the heart.
Authors:Allanore Y, Distler O, Walker UA, Khanna D, Furst DE, Meune C
Institution:Department of Rheumatology A, Cochin Hospital and Cochin Institute, AP-HP, Paris-Descartes University, Paris, France. Scleroderma Program, Ann Arbor, MI. California in Los Angeles, Los Angeles, CA, USA.
Journal:Rheumatology (Oxford). 2017 Sep 1;56(suppl_5):v12-v16. doi: 10.1093/rheumatology/kex198.

12:Muscle involvement in systemic sclerosis: points to consider in clinical trials.
Authors:Walker UA, Clements PJ, Allanore Y, Distler O, Oddis CV, Khanna D, Furst DE
Institution:Department of Rheumatology, Basel University, Basel, Switzerland. California Los Angeles, Los Angeles, CA, USA. Hospital, Paris, France. of Medicine, Pittsburgh, PA. Scleroderma Program, Ann Arbor, MI, USA. California Los Angeles, Los Angeles, CA, USA.
Journal:Rheumatology (Oxford). 2017 Sep 1;56(suppl_5):v38-v44. doi: 10.1093/rheumatology/kex196.

13:Clinical and epidemiological differences between men and women with systemic sclerosis: a study in a Spanish systemic sclerosis cohort and literature review.
Authors:Freire M, Rivera A, Sopena B, Tolosa Vilella C, Guillen-Del Castillo A, Colunga Arguelles D, Callejas Rubio JL, Rubio Rivas M, Trapiella Martinez L, Todoli Parra JA, Rodriguez Carballeira M, Iniesta Arandia N, Garcia Hernandez FJ, Egurbide Arberas MV, Saez Comet L, Vargas Hitos JA, Rios Blanco JJ, Marin Ballve A, Pla Salas X, Madronero Vuelta AB, Ruiz Munoz M, Fonollosa Pla V, Simeon Aznar CP
Institution:Thrombosis and Vasculitis Unit, Department of Internal Medicine, Complexo Hospitalario Universitario de Vigo, Spain. maria.carmen.freire.dapena@sergas.es. Hospitalario Universitario de Vigo, Spain. Spain. Sabadell, Barcelona, Spain. D'Hebron, Barcelona, Spain. Oviedo, Spain. Spain. L'Hospitalet de Llobregat, Barcelona, Spain. Valencia, Spain. Spain. Hospital Clinic, Barcelona, Spain. Hospital Universitario Virgen del Rocio, Sevilla, Spain. Spain. Granada, Spain. Zaragoza, Spain. Madrid, Spain. D'Hebron, Barcelona, Spain. D'Hebron, Barcelona, Spain.
Journal:Clin Exp Rheumatol. 2017 Sep-Oct;35 Suppl 106(4):89-97. Epub 2017 Sep 18.

14:Long-term treatment of scleroderma-related digital ulcers with iloprost: a cohort study.
Authors:Colaci M, Lumetti F, Giuggioli D, Guiducci S, Bellando-Randone S, Fiori G, Matucci-Cerinic M, Ferri C
Institution:Rheumatology Unit, Scleroderma Unit, University of Modena and Reggio Emilia, Modena, Italy. michelecolaci@virgilio.it.; Department of Experimental and Clinical Medicine, University of Florence, and Department of Geriatric Medicine, Division of Rheumatology and Scleroderma Unit AOUC, Florence, Italy.
Journal:Clin Exp Rheumatol. 2017 Sep-Oct;35 Suppl 106(4):179-183. Epub 2017 Sep 18.

15:Very Early Systemic Sclerosis and Pre-systemic Sclerosis: Definition, Recognition, Clinical Relevance and Future Directions.
Authors:Bellando-Randone S, Matucci-Cerinic M
Institution:Department of Experimental and Clinical Medicine, University of Florence, V. Pieraccini 18, 50139, Florence, Italy. s.bellandorandone@gmail.com. Italy. s.bellandorandone@gmail.com. Pieraccini 18, 50139, Florence, Italy. Italy.
Journal:Curr Rheumatol Rep. 2017 Sep 18;19(10):65. doi: 10.1007/s11926-017-0684-2.

16:Efficacy of intensive hand physical therapy in patients with systemic sclerosis.
Authors:Horvath J, Balint Z, Szep E, Deiszinger A, Minier T, Farkas N, Torok E, Horvathne Papp E, Komjati D, Mando Z, Czirjak L, Varju C
Institution:Saint Andrew Hospital for Rheumatic Diseases, Heviz, Hungary. Hungary. Hungary. Hungary. Hungary. Hungary. cecilia.varju@aok.pte.hu.
Journal:Clin Exp Rheumatol. 2017 Sep-Oct;35 Suppl 106(4):159-166. Epub 2017 Aug 30.

17:Autologous stem cell transplantation in systemic sclerosis: a systematic review.
Authors:Host L, Nikpour M, Calderone A, Cannell P, Roddy J
Institution:The Department of Rheumatology, Fiona Stanley Hospital, Murdoch, Western Australia, Australia. Vincent's Hospital Melbourne, Fitzroy, Victoria, Australia. Victoria, Australia. Australia, Australia. Australia, Australia. janet.roddy@health.wa.gov.au.
Journal:Clin Exp Rheumatol. 2017 Sep-Oct;35 Suppl 106(4):198-207. Epub 2017 Aug 30.

18:Six-Minute Walk Test as a Predictor of Diagnosis, Disease Severity, and Clinical Outcomes in Scleroderma-Associated Pulmonary Hypertension: The DIBOSA Study.
Authors:Gadre A, Ghattas C, Han X, Wang X, Minai O, Highland KB
Institution:Internal Medicine, Cleveland Clinic Foundation, Cleveland, OH, USA. MA, USA. Cleveland, OH, 44195, USA. Cleveland, OH, 44195, USA. Cleveland, OH, 44195, USA. highlak@ccf.org.
Journal:Lung. 2017 Oct;195(5):529-536. doi: 10.1007/s00408-017-0034-1. Epub 2017 Jun 23.

19:Three-year trajectories of disability and fatigue in systemic sclerosis: a cohort study.
Authors:Willems LM, Kwakkenbos L, Vonk MC, van den Hoogen FHJ, Vliet Vlieland TPM, van den Ende CHM
Institution:Department of Rheumatology, Sint Maartenskliniek, Nijmegen, The Netherlands. Medical Research, Jewish General Hospital, Montreal, Quebec, Canada; and Behavioural Science Institute, Clinical Psychology, Radboud University, Nijmegen, The Netherlands. Netherlands. Rheumatology, Radboud University Medical Center, Nijmegen, The Netherlands. Netherlands.
Journal:Clin Exp Rheumatol. 2017 Sep-Oct;35 Suppl 106(4):48-55. Epub 2017 Mar 8.

For a FREE PREVIEW of the Medifocus Guidebook on Scleroderma click here

To purchase a copy of the COMPLETE Medifocus Guidebook on Scleroderma click here

To subscribe to additional FREE Medifocus Digest Alert on other disease/condition areas click here

  
Get the Medifocus Guidebook on Scleroderma...
at a Special 20% Discount


Medifocus Guidebook on Scleroderma

Updated: January 11, 2018
164 Pages

This one of a kind Guidebook offers:

  • Answers to your critical health questions including the latest treatments, clinical trials, and expert research.
     
  • High Quality, Professional level information you can trust and understand culled from the latest peer-reviewed journals.
     
  • Timely, up to date content with free guidebook updates for 1 year.
     
  • A unique resource to find leading experts, institutions, and support organizations including contact information and hyperlinks.
     
  • Over 130,000 Guidebooks Sold
     
  • 100% Risk Free Money Back Guarantee



ORDER THE GUIDEBOOK

The Medifocus Guidebook on Scleroderma is available in the following two convenient formats:

PRINTED GUIDEBOOK

Soft-cover book that is available for immediate shipping via either U.S. Priority Mail or International AirMail (outside the U.S.).

  • Regular List Price = $36.95
  • Less 20% Discount = - $7.40
  • Discounted Price = $29.55(excluding shipping & handling)

Order the Printed Guidebook

DIGITAL GUIDEBOOK

Available for immediate download as a PDF document.

  • Regular List Price = $27.95
  • Less 20% Discount = - $5.60
  • Discounted Price = $22.35

Order the Digital Guidebook



Order by Phone

Call Toll Free in the U.S.
1-800-965-3002

From Outside the U.S.
1-301-649-9300

You can also receive a 20% discount when you order your Guidebook by phone.

To receive your 20% discount, simply mention the Discount Coupon Code below to the customer service representative taking your order.

Discount Coupon Code for
Phone Orders

SC32858424

Coupon Expires: March 21, 2018



What Our Customers Are Saying...

"I found the MediFocus Guidebook on Scleroderma to be very comprehensive and easy to read. While it covers the "basics" of the disease that all patients need to know, it also provides more advanced information about the latest research and scientific advances. In a nutshell, the Scleroderma Guidebook is a tremendous resource for anyone who wants to become more educated about this autoimmune disorder and gain a clearer understanding of the medical issues."
L.M.R.
Danville, Virginia


"The MediFocus Guidebook on Scleroderma provides a vast amount of important, practical information about this condition that is supported by an extensive list of references from reputable medical sources. The Guidebook not only has helped to answer many of my questions but has also given me the confidence to discuss my treatment options with my Rheumatologist in far greater detail than I could have done before reading the book. Thank you for providing this valuable Guidebook."
G.D.
South Bend, Indiana


"The MediFocus Guidebook on Scleroderma helped me to understand my condition. In South Africa there is no support network for Scleroderma so your updates on new treatments will benefit me in educating myself to manage my disease. Thank you."
G.M.B.
Eastern Cape, South Africa



  
Medifocus Digest Alert is published monthly by Medifocus, Inc.
6810 Park Heights Avenue, Suite C5, Baltimore, MD 21215 USA
Copyright © 2013 Medifocus, Inc. All rights reserved.