Sjogren's Syndrome
December 2022 Issue
 
 
 

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Sjogren's Syndrome abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Sjogren's Syndrome. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Sjogren's Syndrome. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Sjogren's Syndrome every 3 months. Thank you for your ongoing subscription to this publication.

Elliot Jacob, Ph.D.
Vice-President - Content
Medifocus.com, Inc.



1:The Future of Targeted Treatment of Primary Sjögren's Syndrome: A Focus on Extra-Glandular Pathology.
Authors:Zeng W, Zhou X, Yu S, Liu R, Quek CWN, Yu H, Tay RYK, Lin X, Feng Y
Institution:Department of Ophthalmology, Peking University Third Hospital, Beijing 100191, China.
Journal:Int J Mol Sci. 2022 Nov 16;23(22):14135. doi: 10.3390/ijms232214135.

2:A meta-analysis of the effect of Sjögren's syndrome on adverse pregnancy outcomes.
Authors:Geng B, Zhang K, Huang X, Chen Y
Institution:Department of Rheumatology and Immunology, Ningbo Huamei hospital, University of Chinese Academy of Sciences, Ningbo, Zhejiang, China. Electronic address: chenyongg4@163.com.
Journal:Clinics (Sao Paulo). 2022 Nov 17;77:100140. doi: 10.1016/j.clinsp.2022.100140. eCollection 2022.

3:Clinical Study of the Relationship between Sjögren Syndrome and T-Cell Large Granular Lymphocytic Leukemia: Single-Center Experience.
Authors:Gorodetskiy V, Vasilyev V, Sidorova Y, Biderman B, Kupryshina N, Vagida M, Ryzhikova N, Sudarikov A
Institution:Department of Intensive Methods of Therapy, V.A. Nasonova Research Institute of Rheumatology, 115522 Moscow, Russia.; Laboratory of Molecular Hematology, National Medical Research Center for Hematology, 125167 Moscow, Russia.
Journal:Int J Mol Sci. 2022 Nov 1;23(21):13345. doi: 10.3390/ijms232113345.

4:Efficacy and Safety of Low-Dose Interleukin 2 for Primary Sjögren Syndrome: A Randomized Clinical Trial.
Authors:He J, Chen J, Miao M, Zhang R, Cheng G, Wang Y, Feng R, Huang B, Luan H, Jia Y, Jin Y, Zhang X, Shao M, Wang Y, Zhang X, Li J, Zhao X, Wang H, Liu T, Xiao X, Zhang X, Su Y, Mu R, Ye H, Li R, Liu X, Liu Y, Li C, Liu H, Hu F, Guo J, Liu W, Zhang WB, Jacob A, Ambrus JL Jr, Ding C, Yu D, Sun X, Li Z
Institution:Department of Rheumatology and Immunology, Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis, Peking University People's Hospital, Beijing, China.
Journal:JAMA Netw Open. 2022 Nov 1;5(11):e2241451. doi: 10.1001/jamanetworkopen.2022.41451.

5:Sensorineural Hearing Loss in Sjögren's Syndrome.
Authors:Okawa Y, Ihara K
Institution:Department of Pediatrics, Oita University Faculty of Medicine, Oita 879-5593, Japan.
Journal:Int J Mol Sci. 2022 Sep 23;23(19):11181. doi: 10.3390/ijms231911181.

6:Smell and Taste Function and Their Disturbances in Sjögren's Syndrome.
Authors:Błochowiak K
Institution:Department of Oral Surgery and Periodontology, Poznan University of Medical Sciences, 61-812 Poznan, Poland.
Journal:Int J Environ Res Public Health. 2022 Sep 30;19(19):12472. doi: 10.3390/ijerph191912472.

7:Hospitalizations for infections in primary Sjögren's syndrome patients: a nationwide incidence study.
Authors:Goulabchand R, Makinson A, Morel J, Witkowski-Durand-Viel P, Nagot N, Loubet P, Roubille C, Noel D, Morquin D, Henry K, Mura T, Guilpain P
Institution:Internal Medicine Department, CHU Nimes, University Montpellier, Nimes, France.; University of Montpellier, Montpellier, France.
Journal:Ann Med. 2022 Dec;54(1):2672-2680. doi: 10.1080/07853890.2022.2126517.

8:Dental implants in dentate primary and secondary Sjögren's syndrome patients: A multicenter prospective cohort study.
Authors:Maarse F, Fennis WMM, Twisk JWR, Korfage A, Santing HJ, den Hartog L, Muradin MSM, Maningky MS, Raghoebar GM, Vissink A, Brand HS, Jager DHJ
Institution:Department of Maxillofacial Surgery and Oral Pathology, Amsterdam UMC and Academic Centre for Dentistry Amsterdam (ACTA), Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Journal:Clin Oral Implants Res. 2022 Nov;33(11):1157-1170. doi: 10.1111/clr.13998. Epub 2022 Oct 6.

9:Importance of anti-centromere antibodies in the diagnosis of Sjögren's syndrome.
Authors:Kitagawa M, Sugimoto T, Ogawa I, Miyauchi M, Hirata S, Sugiyama E
Institution:Center of Oral Clinical Examination, Hiroshima University Hospital.; Department of Clinical Immunology and Rheumatology, Hiroshima University Hospital.
Journal:J Oral Sci. 2022 Oct 1;64(4):324-326. doi: 10.2334/josnusd.22-0231. Epub 2022 Sep 12.

10:Illness Experience and Quality of Life in Sjögren Syndrome Patients.
Authors:Rojas-Alcayaga G, Herrera A, Espinoza I, Rios-Erazo M, Aguilar J, Leiva L, Shakhtur N, Wurmann P, Geenen R
Institution:Behavioral Science Area, Institute for Research in Dental Science, Faculty of Dentistry, Universidad de Chile, Santiago 8380544, Chile.; Department of Psychology, Utrecht University, 3584 CS Utrecht, The Netherlands.
Journal:Int J Environ Res Public Health. 2022 Sep 2;19(17):10969. doi: 10.3390/ijerph191710969.

11:Pediatric rheumatologists' perspectives on diagnosis, treatment, and outcomes of Sjögren disease in children and adolescents.
Authors:Randell RL, Stern SM, Van Mater H, Schanberg LE, Lieberman SM, Basiaga ML
Institution:Division of Pediatric Rheumatology, Department of Pediatrics, Duke University School of Medicine, MD 2301 Erwin Rd., Box #3212, Durham, NC, 27705, USA. rachel.randell@duke.edu.; Division of Pediatric Rheumatology, Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA.
Journal:Pediatr Rheumatol Online J. 2022 Sep 5;20(1):79. doi: 10.1186/s12969-022-00740-4.

12:Neuropsychiatric manifestations in primary Sjogren syndrome.
Authors:Appenzeller S, Andrade SO, Bombini MF, Sepresse SR, Reis F, França MC Jr
Institution:Department of Orthopedics, Rheumatology and Traumatology, School of Medical Science, University of Campinas, Campinas, Brazil.; Department of Neurology, School of Medical Science, University of Campinas, Campinas, Brazil.
Journal:Expert Rev Clin Immunol. 2022 Oct;18(10):1071-1081. doi: 10.1080/1744666X.2022.2117159. Epub 2022 Sep 19.

13:A Systematic Review and Meta-Analysis of 19 Randomized Controlled Trials of Iguratimod Combined With Other Therapies for Sjogren's Syndrome.
Authors:Zeng L, He Q, Yang K, Hao W, Yu G, Chen H
Institution:Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China.
Journal:Front Immunol. 2022 Jul 28;13:924730. doi: 10.3389/fimmu.2022.924730. eCollection 2022.

14:The interplay between cognition, depression, anxiety, and sleep in primary Sjogren's syndrome patients.
Authors:Goulabchand R, Castille E, Navucet S, Etchecopar-Etchart D, Matos A, Maria A, Gutierrez LA, Le Quellec A, de Champfleur NM, Gabelle A, Guilpain P
Institution:Internal Medicine Department, CHU Nimes, Place du Pr Debre, 30029, Nimes Cedex, France. radjiv.goulabchand@chu-nimes.fr.; University of Montpellier, Montpellier, France.
Journal:Sci Rep. 2022 Aug 1;12(1):13176. doi: 10.1038/s41598-022-17354-1.

15:Virus Infections Play Crucial Roles in the Pathogenesis of Sjögren's Syndrome.
Authors:Otsuka K, Sato M, Tsunematsu T, Ishimaru N
Institution:Department of Oral Molecular Pathology, Tokushima University Graduate School of Biomedical Sciences, Tokushima 770-8504, Japan.
Journal:Viruses. 2022 Jul 4;14(7):1474. doi: 10.3390/v14071474.

16:Risk, Incidence, and Mortality of Breast Cancer in Primary Sjögren's Syndrome: A Systematic Review and Meta-Analysis.
Authors:Deng J, Liu M, Xiao R, Wang J, Liao X, Ye Z, Sun Z
Institution:Department of Thyroid Breast Surgery, The Second Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, China.; Department of Clinical Medicine, Hengyang Medical School, University of South China, Hengyang, China.
Journal:Front Immunol. 2022 Jul 1;13:904682. doi: 10.3389/fimmu.2022.904682. eCollection 2022.

17:TAFRO syndrome: A severe manifestation of Sjogren's syndrome? A systematic review.
Authors:Grange L, Chalayer E, Boutboul D, Paul S, Galicier L, Gramont B, Killian M
Institution:Department of Internal Medicine, Centre Hospitalier Universitaire de Saint-Etienne, Saint-Etienne, France.; Department of Internal Medicine, Centre Hospitalier Universitaire de Saint-Etienne, Saint-Etienne, France; CIRI - Centre International de Recherche en Infectiologie, Team GIMAP, Universite Jean Monnet, Unversite Claude Bernard Lyon 1, Inserm, U1111, CNRS, UMR530, F42023 Saint-Etienne, France; CIC 1408 Inserm, Centre Hospitalier Universitaire de Saint-Etienne, Saint-Etienne, France. Electronic address: martin.killian@chu-st-etienne.fr.
Journal:Autoimmun Rev. 2022 Aug;21(8):103137. doi: 10.1016/j.autrev.2022.103137. Epub 2022 Jul 6.

18:Liver Fibrosis in Primary Sjögren's Syndrome.
Authors:Androutsakos T, Voulgaris TA, Bakasis AD, Koutsompina ML, Chatzis L, Argyropoulou OD, Pezoulas V, Fotiadis DI, Papatheodoridis G, Tzioufas AG, Goules AV
Institution:Department of Pathophysiology, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
Journal:Front Immunol. 2022 Jun 15;13:889021. doi: 10.3389/fimmu.2022.889021. eCollection 2022.

19:Clinical and laboratory evaluation of sicca complaints: distinctive aspects of primary, secondary and non-Sjogren syndrome.
Authors:de Oliveira FR, Motta ACF, Módulo CM, Garcia DM, Chiorini JA, Louzada-Junior P, Rocha EM
Institution:Ribeirao Preto Medical School, Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, SP, Brazil.
Journal:Adv Rheumatol. 2022 Jul 1;62(1):23. doi: 10.1186/s42358-022-00255-2.

20:Cardiovascular Disease in Primary Sjögren's Syndrome: Raising Clinicians' Awareness.
Authors:Casian M, Jurcut C, Dima A, Mihai A, Stanciu S, Jurcut R
Institution:Cardiology Department, University of Medicine and Pharmacy 'Carol Davila', Bucharest, Romania.
Journal:Front Immunol. 2022 Jun 9;13:865373. doi: 10.3389/fimmu.2022.865373. eCollection 2022.

21:Preferences of Sjögren's syndrome patients regarding potential new saliva substitutes.
Authors:Assy Z, Bikker FJ, Mashhour E, Asadi M, Brand HS
Institution:Department of Oral Biochemistry, Academic Centre for Dentistry Amsterdam, University of Amsterdam and Vrije University Amsterdam, Amsterdam, the Netherlands. z.assy@acta.nl.
Journal:Clin Oral Investig. 2022 Oct;26(10):6245-6252. doi: 10.1007/s00784-022-04576-w. Epub 2022 Jun 11.

22:Cardiovascular Involvement in Sjögren's Syndrome.
Authors:Atzeni F, Gozza F, Cafaro G, Perricone C, Bartoloni E
Institution:Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.; Rheumatology Unit, Department of Medicine and Surgery, University of Perugia, Perugia, Italy.
Journal:Front Immunol. 2022 May 6;13:879516. doi: 10.3389/fimmu.2022.879516. eCollection 2022.

23:Scleroderma-specific autoantibodies: Should they be included in the diagnostic work-up for Sjögren's syndrome?
Authors:Marketos N, Koulouri V, Piperi EP, Georgaki ME, Nikitakis NG, Mavragani CP
Institution:Department of Physiology, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.; Department of Physiology, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece; Fourth Department of Internal Medicine, School of Medicine, University Hospital Attikon, NKUA, 12462 Haidari, Greece; Joint Academic Rheumatology Program, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece. Electronic address: kmauragan@med.uoa.gr.
Journal:Semin Arthritis Rheum. 2022 Aug;55:152026. doi: 10.1016/j.semarthrit.2022.152026. Epub 2022 May 18.

24:Current and future treatment in primary Sjögren's syndrome - A still challenging development.
Authors:Ritter J, Chen Y, Stefanski AL, Dörner T
Institution:Department of Rheumatology and Clinical Immunology, Charite-Universitatsmedizin Berlin, Berlin, Germany; Berlin Institute of Health (BIH), Berlin, Germany.; Department of Rheumatology and Clinical Immunology, Charite-Universitatsmedizin Berlin, Berlin, Germany; German Rheumatism Research Center (DRFZ), a Leibniz Gesellschaft, Berlin, Germany. Electronic address: thomas.doerner@charite.de.
Journal:Joint Bone Spine. 2022 Nov;89(6):105406. doi: 10.1016/j.jbspin.2022.105406. Epub 2022 May 7.

25:Safety and efficacy of filgotinib, lanraplenib and tirabrutinib in Sjögren's syndrome: a randomized, phase 2, double-blind, placebo-controlled study.
Authors:Price E, Bombardieri M, Kivitz A, Matzkies F, Gurtovaya O, Pechonkina A, Jiang W, Downie B, Mathur A, Mozaffarian A, Mozaffarian N, Gottenberg JE
Institution:Department of Rheumatology, Great Western Hospital, Swindon.; Hopitaux Universitaires de Strasbourg et Universite de Strasbourg, and Centre de Reference pour les Maladies Auto-Immunes Systemiques Rares, CNRS, IBMC, UPR3572, Strasbourg, France.
Journal:Rheumatology (Oxford). 2022 Nov 28;61(12):4797-4808. doi: 10.1093/rheumatology/keac167.

26:Dry eye in Sjögren's syndrome - characteristics and therapy.
Authors:Caban M, Omulecki W, Latecka-Krajewska B
Institution:Department of Ophthalmology, Medical University Barlicki Hospital No. 1, 37808Medical University of Lodz, Lodz, Poland.
Journal:Eur J Ophthalmol. 2022 Nov;32(6):3174-3184. doi: 10.1177/11206721221091375. Epub 2022 Mar 30.

27:Primary Sjögren's syndrome is associated with increased risk of malignancies besides lymphoma: A systematic review and meta-analysis.
Authors:Zhong H, Liu S, Wang Y, Xu D, Li M, Zhao Y, Zeng X
Institution:Department of Rheumatology and Clinical Immunology, Chinese Academy of Medical Sciences & Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science & Technology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital (PUMCH), Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China.
Journal:Autoimmun Rev. 2022 May;21(5):103084. doi: 10.1016/j.autrev.2022.103084. Epub 2022 Mar 24.

28:Inactivated SARS-CoV-2 vaccine in primary Sjögren's syndrome: humoral response, safety, and effects on disease activity.
Authors:Pasoto SG, Halpern ASR, Guedes LKN, Ribeiro ACM, Yuki ENF, Saad CGS, da Silva CAA, de Vinci Kanda Kupa L, Villamarín LEB, de Oliveira Martins VA, Martins CCMF, Deveza GBH, Leon EP, Bueno C, Pedrosa TN, Santos REB, Soares R, Aikawa NE, Bonfa E
Institution:Rheumatology Division, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Av. Dr. Arnaldo, 455, 3 andar, sala 3190, Sao Paulo, SP, 01246-903, Brazil. sandra.pasoto@hc.fm.usp.br.
Journal:Clin Rheumatol. 2022 Jul;41(7):2079-2089. doi: 10.1007/s10067-022-06134-x. Epub 2022 Mar 19.

29:A comprehensive overview of living with Sjögren's: results of a National Sjögren's Foundation survey.
Authors:McCoy SS, Woodham M, Bunya VY, Saldanha IJ, Akpek EK, Makara MA, Baer AN
Institution:Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA. ssmccoy@medicine.wisc.edu.; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Journal:Clin Rheumatol. 2022 Jul;41(7):2071-2078. doi: 10.1007/s10067-022-06119-w. Epub 2022 Mar 8.

30:Emerging therapeutics in the management of connective tissue disease. Part I. Lupus erythematosus and Sjögren syndrome.
Authors:Skudalski L, Shahriari N, Torre K, Santiago S, Bibb L, Kodomudi V, Grant-Kels JM, Lu J
Institution:Geisinger Commonwealth School of Medicine, Scranton, Pennsylvania.; Department of Dermatology, University of Connecticut Health Center, Farmington, Connecticut. Electronic address: jlu@uchc.edu.
Journal:J Am Acad Dermatol. 2022 Jul;87(1):1-18. doi: 10.1016/j.jaad.2021.12.067. Epub 2022 Feb 22.

31:Effects of primary Sjögren's syndrome on hearing and vestibular systems.
Authors:Ulusoy B, Limon M, Yılmaz S, Çolpan B, Aygün AA, Körez MK, Erdur Ö
Institution:Department of Otorhinolaryngology - Head and Neck Surgery, Faculty of Medicine, Selcuk University, Konya, Turkey.
Journal:J Laryngol Otol. 2022 Dec;136(12):1254-1258. doi: 10.1017/S0022215122000391. Epub 2022 Feb 2.

32:Primary Sjögren's syndrome: Longitudinal real-world, observational data on health-related quality of life.
Authors:Tarn J, Lendrem D, McMeekin P, Lendrem C, Hargreaves B, Ng WF
Institution:Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.
Journal:J Intern Med. 2022 Jun;291(6):849-855. doi: 10.1111/joim.13451. Epub 2022 Jan 24.

33:Clinical picture, outcome and predictive factors of lymphoma in primary Sjögren's syndrome: results from a harmonized dataset (1981-2021).
Authors:Chatzis LG, Stergiou IE, Goules AV, Pezoulas V, Tsourouflis G, Fotiadis D, Tzioufas AG, Voulgarelis M
Institution:Department of Pathophysiology, School of Medicine, National and Kapodistrian University of Athens.
Journal:Rheumatology (Oxford). 2022 Aug 30;61(9):3576-3585. doi: 10.1093/rheumatology/keab939.

34:The frequency of obstructive sleep apnea in patients with primary Sjogren's syndrome.
Authors:Karabul E, Borekci S, Ugurlu S, Musellim B
Institution:Department of Pulmonary Diseases, Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, Istanbul, 34098, Turkey.
Journal:Sleep Breath. 2022 Dec;26(4):1583-1591. doi: 10.1007/s11325-021-02491-0. Epub 2021 Nov 12.

35:Association of immunological features with clinical manifestations in primary Sjogren's syndrome: a single-center cross-sectional study.
Authors:Relangi HSK, Naidu GSRSNK, Sharma V, Kumar M, Dhir V, Sharma SK, Sharma A, Minz RW, Jain S
Institution:Department of Internal Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Journal:Clin Exp Med. 2022 Nov;22(4):613-620. doi: 10.1007/s10238-021-00772-2. Epub 2021 Nov 11.

36:Comparative analysis of the efficacy and safety of herbal decoction CheReCunJin alone and combined with hydroxychloroquine for treating primary Sjögren's syndrome: A randomized controlled trial.
Authors:Shao Q, Jin L, Li C, Wang J, Wang M, Wang Q, Wu B
Institution:Department of Rheumatology, Chongqing Hospital of Traditional Chinese Medicine, Chongqing 400021, China.; Department of Rheumatology, Chongqing Hospital of Traditional Chinese Medicine, Chongqing 400021, China; Chongqing Key Laboratory of Traditional Chinese Medicine to Prevent and Treat Autoimmune Diseases, Chongqing 400021, China. Electronic address: wuubinn@126.com.
Journal:Explore (NY). 2022 Jul-Aug;18(4):416-422. doi: 10.1016/j.explore.2021.08.002. Epub 2021 Aug 12.

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