Sjogren's Syndrome
December 2017 Issue
 
 
 

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Sjogren's Syndrome abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Sjogren's Syndrome. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Sjogren's Syndrome. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Sjogren's Syndrome every 3 months. Thank you for your ongoing subscription to this publication.

Sincerely,
Elliot Jacob, Ph.D.
Vice-President - Content
Medifocus.com, Inc.



1:A qualitative exploration of physical, mental and ocular fatigue in patients with primary Sjogren's Syndrome.
Authors:Stack RJ, Southworth S, Fisher BA, Barone F, Buckley CD, Rauz S, Bowman SJ
Institution:Centre for Translational Inflammation Research, University of Birmingham, Birmingham, United Kingdom.; Academic Unit of Ophthalmology, Birmingham and Midland Eye Centre, Birmingham, United Kingdom.; Department of Rheumatology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom.
Journal:PLoS One. 2017 Oct 31;12(10):e0187272. doi: 10.1371/journal.pone.0187272. eCollection 2017.

2:Risk of Ischemic Heart Disease in Patients With Sjogren's Syndrome.
Authors:Luni FK, Malik SA, Khan AR, Riaz H, Singh H, Federman D, Kanjwal Y, Dasa O, Khuder S, Kabour A
Institution:Department of Cardiovascular Diseases, Mercy Saint Vincent Medical Center, Toledo, Ohio. Electronic address: fluni@mercy.com. Kentucky. Toledo, Ohio. Ohio. Ohio. Toledo, Ohio.
Journal:Am J Med Sci. 2017 Oct;354(4):395-398. doi: 10.1016/j.amjms.2017.05.001. Epub 2017 May 4.

3:The value of rituximab treatment in primary Sjogren's syndrome.
Authors:Verstappen GM, van Nimwegen JF, Vissink A, Kroese FGM, Bootsma H
Institution:Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. Electronic address: g.m.p.j.verstappen@umcg.nl.; Department of Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Journal:Clin Immunol. 2017 Sep;182:62-71. doi: 10.1016/j.clim.2017.05.002. Epub 2017 May 3.

4:Sjogren's syndrome from the perspective of ophthalmology.
Authors:Kuklinski E, Asbell PA
Institution:Department of Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States. NY 10029, United States; Department of Ophthalmology, Icahn School of Medicine at Mount Sinai, NY, New York 10029, United States. Electronic address: penny.asbell@mssm.edu.
Journal:Clin Immunol. 2017 Sep;182:55-61. doi: 10.1016/j.clim.2017.04.017. Epub 2017 May 2.

5:Sjogren's syndrome: Clinical aspects.
Authors:Vivino FB
Institution:Division of Rheumatology, Penn Presbyterian Medical Center, United States; Penn Sjogren's Syndrome Center, Perelman School of Medicine, University of Pennsylvania, United States.
Journal:Clin Immunol. 2017 Sep;182:48-54. doi: 10.1016/j.clim.2017.04.005. Epub 2017 Apr 17.

6:Vitamin D and Sjogren syndrome.
Authors:Garcia-Carrasco M, Jimenez-Herrera EA, Galvez-Romero JL, de Lara LV, Mendoza-Pinto C, Etchegaray-Morales I, Munguia-Realpozo P, Ruiz-Arguelles A, Jose R, Vera-Recabarren M, Cervera R
Institution:Systemic Autoimmune Diseases Research Unit, General Regional Hospital No. 36, Instituto Mexicano del Seguro Social, Puebla, Mexico; Department of Rheumatology and Immunology, Medicine School, Benemerita Universidad Autonoma de Puebla, Puebla, Mexico. Instituto Mexicano del Seguro Social, Puebla, Mexico. Seguridad y Servicios Sociales de los Trabajadores del Estado, ISSSTE, Puebla, Mexico. Autonoma de Puebla, Puebla, Mexico. Instituto Mexicano del Seguro Social, Puebla, Mexico; Department of Rheumatology and Immunology, Medicine School, Benemerita Universidad Autonoma de Puebla, Puebla, Mexico. Instituto Mexicano del Seguro Social, Puebla, Mexico. del Seguro Social, Puebla, Mexico. Puebla, Puebla, Mexico. Electronic address: rcervera@clinic.ub.es.
Journal:Autoimmun Rev. 2017 Jun;16(6):587-593. doi: 10.1016/j.autrev.2017.04.004. Epub 2017 Apr 12.

7:Autoantibodies, detection methods and panels for diagnosis of Sjogren's syndrome.
Authors:Shen L, Suresh L
Institution:Department of Rheumatology and Clinical Immunology, The First Affiliated Hospital of Xiamen University, Xiamen University, Xiamen 361003, China; Autoimmune Division, Trinity Biotech, 60 Pineview Drive, Buffalo, NY 14228, USA. Electronic address: shenl@buffalo.edu. Buffalo, Buffalo, NY 14214, USA; Autoimmune Division, Trinity Biotech, 60 Pineview Drive, Buffalo, NY 14228, USA.
Journal:Clin Immunol. 2017 Sep;182:24-29. doi: 10.1016/j.clim.2017.03.017. Epub 2017 Apr 5.

8:Randomized Controlled Trial of Rituximab and Cost-Effectiveness Analysis in Treating Fatigue and Oral Dryness in Primary Sjogren's Syndrome.
Authors:Bowman SJ, Everett CC, O'Dwyer JL, Emery P, Pitzalis C, Ng WF, Pease CT, Price EJ, Sutcliffe N, Gendi NST, Hall FC, Ruddock SP, Fernandez C, Reynolds C, Hulme CT, Davies KA, Edwards CJ, Lanyon PC, Moots RJ, Roussou E, Giles IP, Sharples LD, Bombardieri M
Institution:University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
Journal:Arthritis Rheumatol. 2017 Jul;69(7):1440-1450. doi: 10.1002/art.40093. Epub 2017 Jun 5.

9:An investigation into the prevalence of sleep disturbances in primary Sjogren's syndrome: a systematic review of the literature.
Authors:Hackett KL, Gotts ZM, Ellis J, Deary V, Rapley T, Ng WF, Newton JL, Deane KHO
Institution:Musculoskeletal Research Group, Institute of Cellular Medicine & NIHR Biomedical Research Centre for Ageing and Chronic Diseases. Northumbria University. Research Centre for Ageing and Chronic Diseases. Chronic Diseases, Newcastle upon Tyne.
Journal:Rheumatology (Oxford). 2017 Apr 1;56(4):570-580. doi: 10.1093/rheumatology/kew443.

10:Prevalence of Primary Sjogren's Syndrome in a US Population-Based Cohort.
Authors:Maciel G, Crowson CS, Matteson EL, Cornec D
Institution:Mayo Clinic College of Medicine, Rochester, Minnesota, and Hospital Maciel, Montevideo, Uruguay. Hospital, Brest, France.
Journal:Arthritis Care Res (Hoboken). 2017 Oct;69(10):1612-1616. doi: 10.1002/acr.23173. Epub 2017 Aug 31.

11:Subjective and Objective Measures of Dryness Symptoms in Primary Sjogren's Syndrome: Capturing the Discrepancy.
Authors:Bezzina OM, Gallagher P, Mitchell S, Bowman SJ, Griffiths B, Hindmarsh V, Hargreaves B, Price EJ, Pease CT, Emery P, Lanyon P, Bombardieri M, Sutcliffe N, Pitzalis C, Hunter J, Gupta M, McLaren J, Cooper AM, Regan M, Giles IP, Isenberg DA, Saravanan V, Coady D, Dasgupta B, McHugh NJ, Young-Min SA, Moots RJ, Gendi N, Akil M, MacKay K, Ng WF, Robinson LJ
Institution:Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK. Chapel Allerton Hospital, NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals Trust, Leeds, UK. Chapel Allerton Hospital, NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals Trust, Leeds, UK. Dentistry, London, UK. Dentistry, London, UK. Portsmouth, UK. Biomedical Research Centre for Ageing and Chronic Diseases, Newcastle University, and Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.
Journal:Arthritis Care Res (Hoboken). 2017 Nov;69(11):1714-1723. doi: 10.1002/acr.23165. Epub 2017 Oct 9.

12:Severe Health-Related Quality of Life Impairment in Active Primary Sjogren's Syndrome and Patient-Reported Outcomes: Data From a Large Therapeutic Trial.
Authors:Cornec D, Devauchelle-Pensec V, Mariette X, Jousse-Joulin S, Berthelot JM, Perdriger A, Puechal X, Le Guern V, Sibilia J, Gottenberg JE, Chiche L, Hachulla E, Yves Hatron P, Goeb V, Hayem G, Morel J, Zarnitsky C, Dubost JJ, Saliou P, Pers JO, Seror R, Saraux A
Institution:Centre Hospitalier Universitaire de la Cavale Blanche, and EA 2216, INSERM ESPRI, ERI29, Universite de Brest, LabEx IGO, Brest, France.; Assistance Publique-Hopitaux de Paris, Hopitaux Universitaires Paris-Sud, INSERM U1184, Universite Paris-Sud, Le Kremlin Bicetre, France.; Hotel-Dieu, Centre Hospitalier Universitaire Nantes, Nantes, France.; Centre Hospitalier Universitaire, Hopital Sud, Rennes, France.; Hopital Cochin, Paris, France.
Journal:Arthritis Care Res (Hoboken). 2017 Apr;69(4):528-535. doi: 10.1002/acr.22974.

13:Treatment Guidelines for Rheumatologic Manifestations of Sjogren's Syndrome: Use of Biologic Agents, Management of Fatigue, and Inflammatory Musculoskeletal Pain.
Authors:Carsons SE, Vivino FB, Parke A, Carteron N, Sankar V, Brasington R, Brennan MT, Ehlers W, Fox R, Scofield H, Hammitt KM, Birnbaum J, Kassan S, Mandel S
Institution:Winthrop-University Hospital Campus, State University of New York, Stony Brook, Mineola. Foundation, and Oklahoma City Department of Veterans Affairs Medical Center, Oklahoma City. Hempstead, New York.
Journal:Arthritis Care Res (Hoboken). 2017 Apr;69(4):517-527. doi: 10.1002/acr.22968. Epub 2017 Mar 3.

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