| | Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.
Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Spondylolisthesis abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Spondylolisthesis. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Spondylolisthesis. You can access the summaries of each article referenced below by simply clicking on the article Title.
We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Spondylolisthesis every 3 months. Thank you for your ongoing subscription to this publication.
Elliot Jacob, Ph.D.
Vice-President - Content
Medifocus.com, Inc.
| Authors: | Chuang CY, Liaw MY, Wang LY, Huang YC, Pong YP, Chen CW, Wu RW, Lau YC |
| Institution: | Department of Physical Medicine and Rehabilitation, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan ROC. | | Journal: | J Rehabil Med. 2018 Nov 7;50(10):898-907. doi: 10.2340/16501977-2489. |
| Authors: | Sutovsky J, Sutovska M, Kocmalova M, Kazimierova I, Pappova L, Benco M, Grendar M, Bredvold HH, Miklusica J, Franova S |
| Institution: | Neurosurgery Clinic, Martin University Hospital, Jessenius Faculty of Medicine, Comenius University, Martin, Slovakia.; Department of Pharmacology, Jessenius Faculty of Medicine, Comenius University, Martin, Slovakia. Electronic address: martinka.sutovska@gmail.com.; Department of Pharmacology, Jessenius Faculty of Medicine, Comenius University, Martin, Slovakia; BioMed, Martin's Biomedical Center, Jessenius Faculty of Medicine, Comenius University, Martin, Slovakia.; Transplant and Vascular Surgery Clinic, Martin University Hospital, Jessenius Faculty of Medicine, Comenius University, Martin, Slovakia. | | Journal: | World Neurosurg. 2019 Jan;121:e554-e565. doi: 10.1016/j.wneu.2018.09.163. Epub 2018 Sep 29. |
| Authors: | Shi L, Chen Y, Miao J, Shi J, Chen D |
| Institution: | Spine Center, Department of Orthopaedics, Changzheng Hospital, Second Military Medical University No. 415, Shanghai, China. Electronic address: chen_spine@126.com. | | Journal: | World Neurosurg. 2018 Dec;120:e1017-e1023. doi: 10.1016/j.wneu.2018.08.217. Epub 2018 Sep 7. |
| Authors: | Hayashi K, Toyoda H, Terai H, Hoshino M, Suzuki A, Takahashi S, Tamai K, Ohyama S, Hori Y, Yabu A, Nakamura H |
| Institution: | Department of Orthopaedic Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan. Electronic address: h-toyoda@msic.med.osaka-cu.ac.jp. | | Journal: | J Clin Neurosci. 2018 Nov;57:79-85. doi: 10.1016/j.jocn.2018.08.032. Epub 2018 Aug 25. |
| Authors: | Dohzono S, Toyoda H, Hori Y, Takahashi S, Suzuki A, Terai H, Nakamura H |
| Institution: | Department of Orthopaedic Surgery, Yodogawa Christian Hospital, Osaka, Japan.; Department of Orthopaedic Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan. | | Journal: | J Neurol Surg A Cent Eur Neurosurg. 2018 Nov;79(6):479-485. doi: 10.1055/s-0038-1666847. Epub 2018 Jul 30. |
| Authors: | Telfeian AE, Oyelese A, Fridley J, Gokaslan ZL |
| Institution: | Department of Neurosurgery, Rhode Island Hospital, The Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA. Electronic address: atelfeian@Lifespan.org. | | Journal: | World Neurosurg. 2018 Sep;117:321-325. doi: 10.1016/j.wneu.2018.06.106. Epub 2018 Jun 22. |
| Authors: | Hoel RJ, Brenner RM, Polly DW Jr |
| Institution: | Department of Orthopaedic Surgery, University of Minnesota, 2450 Riverside Avenue South, Suite R200, Minneapolis, MN 55454, USA. South, Suite R200, Minneapolis, MN 55454, USA. South, Suite R200, Minneapolis, MN 55454, USA; Department of Neurosurgery, University of Minnesota, 2450 Riverside Avenue South, Suite R200, Minneapolis, MN 55454, USA. Electronic address: pollydw@umn.edu. | | Journal: | Neurosurg Clin N Am. 2018 Jul;29(3):375-387. doi: 10.1016/j.nec.2018.03.006. |
| Authors: | Seuk JW, Bae J, Shin SH, Lee SH |
| Institution: | Department of Neurosurgery, Chungdam Wooridul Spine Hospital, Seoul, Republic of Korea. Korea. Electronic address: jsbaemd@gmail.com. Korea. Korea. | | Journal: | World Neurosurg. 2018 Sep;117:e493-e499. doi: 10.1016/j.wneu.2018.06.063. Epub 2018 Jun 18. |
| Authors: | Zhu C, Qiu X, Zhuang M, Cheng D, Liu Z |
| Institution: | Department of Spine Surgery, The Third Affiliated Hospital of Soochow University, Changzhou, China. Electronic address: drzhiweiliu@126.com. | | Journal: | World Neurosurg. 2018 Sep;117:e396-e402. doi: 10.1016/j.wneu.2018.06.042. Epub 2018 Jun 15. |
| Authors: | Echt M, De la Garza Ramos R, Nakhla J, Gelfand Y, Cezayirli P, Holland R, Kinon MD, Yassari R |
| Institution: | Spine Research Group, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, New York, USA; Department of Neurological Surgery, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, New York, USA. Electronic address: ryassari@montefiore.org. | | Journal: | World Neurosurg. 2018 Aug;116:e824-e829. doi: 10.1016/j.wneu.2018.05.103. Epub 2018 May 23. |
| Authors: | Kim K, Youn Y, Lee SH, Choi JC, Jung JE, Kim J, Qu W, Eldrige J, Kim TH |
| Institution: | Department of Spine Center, Mokhuri Neck and Back Hospital, Seoul. MN, USA. MN, USA. University, Seoul, Republic of Korea. | | Journal: | Medicine (Baltimore). 2018 May;97(19):e0667. doi: 10.1097/MD.0000000000010667. |
| Authors: | Uysal M, Ozalay M, Derincek A, Kochai A, Turker M |
| Institution: | Department of Orthopedics and Traumatology, Sakarya University Faculty of Medicine, Sakarya, Turkey. University School of Medicine, Adana, Turkey. Turkey. Medicine, Sakarya, Turkey. Electronic address: alkoc79@gmail.com. Medicine, Sakarya, Turkey. | | Journal: | Acta Orthop Traumatol Turc. 2018 Jul;52(4):272-276. doi: 10.1016/j.aott.2018.03.001. Epub 2018 Apr 26. |
| Authors: | Yagi M, Fujita N, Okada E, Tsuji O, Nagoshi N, Tsuji T, Nakamura M, Matsumoto M, Watanabe K |
| Institution: | Department of Orthopedic Surgery, Keio University School of Medicine, Japan; Department of Orthopedic Surgery, National Hospital Organization Murayama Medical Center, Japan; Keio Spine Research Group (KSRG), Japan.; Department of Orthopedic Surgery, Keio University School of Medicine, Japan; Keio Spine Research Group (KSRG), Japan. Electronic address: watakota@gmail.com.; Department of Orthopedic Surgery, Fujita Health University, Japan; Keio Spine Research Group (KSRG), Japan. | | Journal: | J Orthop Sci. 2018 Jul;23(4):653-657. doi: 10.1016/j.jos.2018.04.001. Epub 2018 Apr 24. |
| Authors: | Minamide A, Yoshida M, Simpson AK, Nakagawa Y, Iwasaki H, Tsutsui S, Takami M, Hashizume H, Yukawa Y, Yamada H |
| Institution: | Department of Orthopaedic Surgery, Wakayama Medical University, 811-1 Kimiidera, Wakayama City, Wakayama 641-8510, Japan.; Microendoscopic Spine Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. | | Journal: | Bone Joint J. 2018 Apr 1;100-B(4):499-506. doi: 10.1302/0301-620X.100B4.BJJ-2017-0917.R1. |
| Authors: | Ulrich NH, Gravestock I, Held U, Schawkat K, Pichierri G, Wertli MM, Winklhofer S, Farshad M, Porchet F, Steurer J, Burgstaller JM |
| Institution: | Department of Orthopedics and Neurosurgery, Spine Center, Schulthess Clinic, Zurich, Switzerland; Horten Centre for Patient Oriented Research and Knowledge Transfer, University of Zurich, Zurich, Switzerland. Electronic address: nils.hb.ulrich@gmail.com. Zurich, Zurich, Switzerland. Zurich, Zurich, Switzerland. University of Zurich, Zurich, Switzerland. Zurich, Zurich, Switzerland. Zurich, Zurich, Switzerland; Division of General Internal Medicine, Bern University Hospital, Bern University, Bern, Switzerland. University of Zurich, Zurich, Switzerland. Switzerland. Zurich, Switzerland. Zurich, Zurich, Switzerland. Zurich, Zurich, Switzerland. | | Journal: | World Neurosurg. 2018 Jun;114:e1275-e1283. doi: 10.1016/j.wneu.2018.03.196. Epub 2018 Apr 5. |
| Authors: | Zhang S, Ye C, Lai Q, Yu X, Liu X, Nie T, Zhan H, Dai M, Zhang B |
| Institution: | Department of Orthopedics, The First Affiliated Hospital of Nanchang University, Artificial Joints Engineering and Technology Research Center of Jiangxi Province, No. 17 Yong Wai Zheng Street, Nanchang, Jiangxi, 330006, China. 1135547344@qq.com.; Nanchang University, Nanchang, Jiangxi, 330006, China.; Department of Orthopedics, The First Affiliated Hospital of Nanchang University, Artificial Joints Engineering and Technology Research Center of Jiangxi Province, No. 17 Yong Wai Zheng Street, Nanchang, Jiangxi, 330006, China. acker11@126.com. | | Journal: | J Orthop Surg Res. 2018 Mar 16;13(1):55. doi: 10.1186/s13018-018-0723-3. |
| Authors: | Meissner-Haecker A, Urrutia J |
| Institution: | Facultad de Medicina, Pontificia Universidad Catolica de Chile, Santiago, Chile; Proyecto Epistemonikos, Santiago, Chile. Ortopedia, Facultad de Medicina, Pontificia Universidad Catolica de Chile, Santiago, Chile. Email: jurrutia@med.puc.cl. Address: Centro Evidencia UC, Pontificia Universidad Catolica de Chile, Centro de Innovacion UC Anacleto Angelini, Avda. Vicuna Mackenna 4860, Macul, Santiago, Chile. | | Journal: | Medwave. 2018 Jan 30;18(1):e7147. doi: 10.5867/medwave.2018.01.7146. |
| Authors: | Vail D, Azad TD, O'Connell C, Han SS, Veeravagu A, Ratliff JK |
| Institution: | Department of Neurosurgery. | | Journal: | Spine (Phila Pa 1976). 2018 Aug 1;43(15):1080-1088. doi: 10.1097/BRS.0000000000002509. |
| Authors: | Murphy HA, Warnick E, McEntee R, Nicholson K, Hollern DA, Stawicki C, Tarazona D, Schroeder GD, Woods BI, Kurd MF, Rihn JA, Anderson GD, Kepler CK, Hilibrand AS, Vaccaro AR, Radcliff KE |
| Institution: | The Rothman Institute at Thomas Jefferson University, Philadelphia, PA. | | Journal: | Spine (Phila Pa 1976). 2018 Jun 1;43(11):805-812. doi: 10.1097/BRS.0000000000002459. |
| Authors: | Cushnie D, Johnstone R, Urquhart JC, Gurr KR, Bailey SI, Bailey CS |
| Institution: | Division of Orthopaedics, Department of Surgery, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.; London Health Sciences Center, London, Ontario, Canada.; Lawson Health Research Institute, London, Ontario, Canada. | | Journal: | Spine (Phila Pa 1976). 2018 May 15;43(10):E574-E579. doi: 10.1097/BRS.0000000000002429. |
| Authors: | Tye EY, Tanenbaum JE, Alonso AS, Xiao R, Steinmetz MP, Mroz TE, Savage JW |
| Institution: | Center for Spine Health, Cleveland Clinic, 9500 Euclid Ave, S-40, Cleveland, OH 44195, USA; Case Western Reserve University School of Medicine, 9500 Euclid Ave, S-40, Cleveland, OH 44195, USA; Department of Orthopaedic Surgery, Cleveland Clinic, 9500 Euclid Ave, S-40, Cleveland, OH 44195, USA. Electronic address: eyt4@case.edu.; Center for Spine Health, Cleveland Clinic, 9500 Euclid Ave, S-40, Cleveland, OH 44195, USA; Case Western Reserve University School of Medicine, 9500 Euclid Ave, S-40, Cleveland, OH 44195, USA; Department of Orthopaedic Surgery, Cleveland Clinic, 9500 Euclid Ave, S-40, Cleveland, OH 44195, USA; Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, 9500 Euclid Ave, S-40, Cleveland, OH 44195, USA.; Center for Spine Health, Cleveland Clinic, 9500 Euclid Ave, S-40, Cleveland, OH 44195, USA; Case Western Reserve University School of Medicine, 9500 Euclid Ave, S-40, Cleveland, OH 44195, USA; Department of Neurosurgery, Cleveland Clinic, 9500 Euclid Ave, S-40, Cleveland, OH 44195, USA.; Center for Spine Health, Cleveland Clinic, 9500 Euclid Ave, S-40, Cleveland, OH 44195, USA; Cleveland Clinic Lerner College of Medicine, Cleveland Clinic, 9500 Euclid Ave, S-40, Cleveland, OH 44195, USA.; Center for Spine Health, Cleveland Clinic, 9500 Euclid Ave, S-40, Cleveland, OH 44195, USA; Department of Neurosurgery, Cleveland Clinic, 9500 Euclid Ave, S-40, Cleveland, OH 44195, USA; Cleveland Clinic Lerner College of Medicine, Cleveland Clinic, 9500 Euclid Ave, S-40, Cleveland, OH 44195, USA. | | Journal: | Spine J. 2018 Mar;18(3):464-471. doi: 10.1016/j.spinee.2017.08.227. Epub 2017 Aug 15. |
| Authors: | Kim E, Chotai S, Stonko D, Wick J, Sielatycki A, Devin CJ |
| Institution: | Department of Orthopaedic Surgery, Vanderbilt Spine Institute, Vanderbilt University School of Medicine, Medical Center East, South Tower, Suite 4200, Nashville, TN, 37232-8774, USA. clintondevin@gmail.com. | | Journal: | Eur Spine J. 2018 Mar;27(3):661-669. doi: 10.1007/s00586-017-5142-3. Epub 2017 Jun 5. |
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What Our Customers Are Saying... "The MediFocus Guidebook on Spondylolisthesis provided me with the information I needed to make an informed decision regarding my treatment. The Guidebook clearly explained the various grades of spondylolisthesis and what patients can expect at each stage. The various treatment options are also clearly explained so that you walk away with a much more realistic expectation about what to expect after treatment."
B.F.K.
Shereveport, Louisiana
"The MediFocus Guidebook on Spondylolisthesis enabled me to have a more meaningful and serious discussion with my Orthopedic Surgeon about the various treatment options that are available to me. Your very comprehensive and informative Guidebook not only helped me prepare the right questions to ask my surgeon but also helped me better understand the answers he provided."
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Plano, Texas
"Your MediFocus Guidebook on Spondylolisthesis helped me to prepare important questions to ask my doctors about the risks and complications associated with the proposed surgical solution to my low back problem. Thank you."
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Malvern, Pennsylvania
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