Trigeminal Neuralgia
December 2022 Issue

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Trigeminal Neuralgia abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Trigeminal Neuralgia. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Trigeminal Neuralgia. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Trigeminal Neuralgia every 3 months. Thank you for your ongoing subscription to this publication.

Elliot Jacob, Ph.D.
Vice-President - Content, Inc.

1:Clinical outcome after microvascular decompression for trigeminal neuralgia: a systematic review and meta-analysis.
Authors:Di Carlo DT, Benedetto N, Perrini P
Institution:Department of Neurosurgery, Azienda Ospedaliero Universitaria Pisana (AOUP), Via Paradisa 2, 56100, Pisa, Italy.
Journal:Neurosurg Rev. 2022 Dec 8;46(1):8. doi: 10.1007/s10143-022-01922-0.

2:"They Could Have Cut My Head Off and I Wouldn't Have Cared"-A Qualitative Study of Patient Experiences and the Impact of Trigeminal Neuralgia.
Authors:Nova CV, Zakrzewska JM, Ni Riordain R, Baker SR
Journal:J Oral Facial Pain Headache. 2022 Summer;36(3-4):189–205. doi: 10.11607/ofph.3110. Epub 2022 Nov 28.

3:Treatment of multiple sclerosis-related trigeminal neuralgia with onabotulinumtoxinA.
Authors:Asan F, Gündüz A, Tütüncü M, Uygunoğlu U, Savrun FK, Saip S, Siva A
Institution:Department of Neurology, Cerrahpa?a School of Medicine, Istanbul University-Cerrahpa?a, Istanbul, Turkey.
Journal:Headache. 2022 Nov;62(10):1322-1328. doi: 10.1111/head.14414. Epub 2022 Nov 27.

4:Trigeminal ganglion itself can be a viable target to manage trigeminal neuralgia.
Authors:Kc E, Islam J, Park YS
Institution:Program in Neuroscience, Department of Medicine, College of Medicine, Chungbuk National University, Cheongju, Korea.
Journal:J Headache Pain. 2022 Nov 24;23(1):150. doi: 10.1186/s10194-022-01512-x.

5:Trigeminal Neuralgia.
Authors:Khawaja SN, Scrivani SJ
Institution:Orofacial Pain Medicine, Department of Internal Medicine, Shaukat Khanum Memorial Cancer Hospital & Research Centers, Lahore, Pakistan. Electronic address:; Department of Diagnostic Sciences, Craniofacial Pain Center, Tufts University School of Dental Medicine, Boston, MA, USA.
Journal:Dent Clin North Am. 2023 Jan;67(1):99-115. doi: 10.1016/j.cden.2022.07.008. Epub 2022 Oct 27.

6:Microvascular decompression in trigeminal neuralgia - a prospective study of 115 patients.
Authors:Andersen ASS, Heinskou TB, Rochat P, Springborg JB, Noory N, Smilkov EA, Bendtsen L, Maarbjerg S
Institution:Danish Headache Center, Department of Neurology, Copenhagen University Hospital, Rigshospitalet - Glostrup, Valdemar Hansens Vej 5, 2600, Glostrup, Denmark.
Journal:J Headache Pain. 2022 Nov 19;23(1):145. doi: 10.1186/s10194-022-01520-x.

7:CyberKnife radiosurgery for trigeminal neuralgia: a retrospective review of 168 cases.
Authors:Guillemette A, Heymann S, Roberge D, Ménard C, Fournier-Gosselin MP
Institution:1Centre de Recherche du Centre Hospitalier de l'Universite de Montreal (CR-CHUM).
Journal:Neurosurg Focus. 2022 Nov;53(5):E4. doi: 10.3171/2022.8.FOCUS22370.

8:Quality of life after trigeminal nerve block in refractory trigeminal neuralgia: A retrospective cohort study and literature review.
Authors:Jacques N, Karoutsos S, Marais L, Nathan-Denizot N
Institution:Department of Anaesthesiology and Intensive Care Medicine, Limoges University Hospital, Limoges, France.
Journal:J Int Med Res. 2022 Oct;50(10):3000605221132027. doi: 10.1177/03000605221132027.

9:Long-term outcomes and predictors of percutaneous radiofrequency thermocoagulation of Gasserian ganglion for maxillary trigeminal neuralgia: a retrospective analysis of 1070 patients with minimum 2-year follow-up.
Authors:Zhao W, Yang L, Deng A, Chen Z, He L
Institution:Department of Pain Management, Xuanwu Hospital, Capital Medical University, Beijing, PR China.
Journal:Ann Med. 2022 Dec;54(1):2420-2430. doi: 10.1080/07853890.2022.2117409.

10:Robotic-assisted stereotactic percutaneous balloon compression for trigeminal neuralgia treatment.
Authors:Graciolli Cordeiro J, Assumpcao de Monaco B, Theodotou CB, Luther E, Benjamin CG, Jagid JR
Institution:Clin. Neurosurgery, University of Miami/Jackson Memorial Hospital, Miami, USA. Electronic address:; Clin. Neurosurgery, University of Miami/Jackson Memorial Hospital, Miami, USA. Electronic address:
Journal:Clin Neurol Neurosurg. 2022 Oct;221:107412. doi: 10.1016/j.clineuro.2022.107412. Epub 2022 Aug 13.

11:Radiofrequency thermoablation of the peripheral branches of trigeminal nerve versus the Gasserian ganglion for treating idiopathic trigeminal neuralgia: A systematic review and meta-analysis.
Authors:Abduhamid AS, Alomari MS, Ghaddaf AA, Mullah AN, Alsharif A, Alqrni AM, Haider M
Institution:College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia; King Abdullah International Medical Research Center, Jeddah, Saudi Arabia. Electronic address:; Department of Anesthesiology, King Abdulaziz Medical City, National Guard Health Affairs, Jeddah, Saudi Arabia.
Journal:J Clin Neurosci. 2022 Oct;104:42-47. doi: 10.1016/j.jocn.2022.08.005. Epub 2022 Aug 11.

12:Percutaneous radiofrequency trigeminal rhizotomy benefits in patients with refractory trigeminal neuralgia.
Authors:Yang CC, Lee MH, Yang JT, Chen KT, Huang WC, Tsai PJ, Kao CH, Liao CW, Lin MH
Institution:Chiayi Chang Gung Memorial Hospital, Pu-Tz, Chia-Yi, Taiwan.
Journal:Medicine (Baltimore). 2022 Jun 24;101(25):e29543. doi: 10.1097/MD.0000000000029543.

13:Cervical Spinal Cord Stimulation for Trigeminal Neuralgia: a Narrative Review.
Authors:Gupta M, Chitneni A, Ghorayeb J, Schnetzer B, Klusek M
Institution:Kansas Pain Management and Neuroscience Research Center, Overland Park, KS, USA.; Peconic Bay Medical Center/Northwell Health, Riverhead, NY, USA.
Journal:Curr Pain Headache Rep. 2022 Aug;26(8):639-645. doi: 10.1007/s11916-022-01066-2. Epub 2022 Jun 18.

14:Clinical outcomes of partial sensory root rhizotomy on patients with recurrence of multiple sclerosing trigeminal neuralgia after percutaneous balloon compression.
Authors:Li Y, Zhang G, Zhang J, Cheng Z, Lan Y
Institution:Department of Neurosurgery, Xinxiang Central Hospital/The Fourth Clinical College of Xinxiang Medical University, Xinxiang 453000, HeNan, China.; Department of Neurosurgery, People's Hospital of Ningxia Hui Autonomous Region, Yinchuan 750002, Ningxia, China. Electronic address:
Journal:Mult Scler Relat Disord. 2022 Jul;63:103883. doi: 10.1016/j.msard.2022.103883. Epub 2022 May 16.

15:The management of trigeminal neuralgia with triptans, a narrative review of the literature.
Authors:Munoz A, Maxwell C, Gofman N, Liebman K, Veznedaroglu E
Institution:Drexel University College of Medicine, Philadelphia, Pennsylvania, USA.; Global Neurosciences Institute, Pennington, New Jersey, USA.
Journal:Headache. 2022 May;62(5):543-547. doi: 10.1111/head.14321.

16:Intravenous lacosamide and phenytoin for the treatment of acute exacerbations of trigeminal neuralgia: A retrospective analysis of 144 cases.
Authors:Muñoz-Vendrell A, Teixidor S, Sala-Padró J, Campoy S, Huerta-Villanueva M
Institution:Neurology Department, Headache Unit, Hospital Universitari de Bellvitge-IDIBELL, Universitat de Barcelona, L'Hospitalet de Llobregat, Barcelona, Spain.
Journal:Cephalalgia. 2022 Sep;42(10):1031-1038. doi: 10.1177/03331024221092435. Epub 2022 Apr 26.

17:Intravenous fosphenytoin as treatment for acute exacerbation of trigeminal neuralgia: A prospective systematic study of 15 patients.
Authors:Andersen ASS, Heinskou TB, Asghar MS, Rossen B, Noory N, Smilkov EA, Bendtsen L, Maarbjerg S
Institution:Danish Headache Center, Department of Neurology, Rigshospitalet - Glostrup, Denmark.
Journal:Cephalalgia. 2022 Oct;42(11-12):1138-1147. doi: 10.1177/03331024221094536. Epub 2022 Apr 25.

18:Long-term recurrence-free survival and complications of percutaneous balloon compression and radiofrequency thermocoagulation of Gasserian ganglion for trigeminal neuralgia: A retrospective study of 1313 cases.
Authors:Zheng S, Yuan R, Ni J, Liu H, Yang Y, Zhang S, Li J
Institution:Department of Pain, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
Journal:Pain Pract. 2022 Jun;22(5):532-540. doi: 10.1111/papr.13114. Epub 2022 May 6.

19:Efficacy and complications of microvascular decompression in patients over 70 years with trigeminal neuralgia.
Authors:Domages C, Brenet E, Labrousse M, Bazin A, Chays A, Kleiber JC, Dubernard X
Institution:Department of Oto-Rhino-Laryngology, Head and Neck Surgery, University Hospital of Reims, 45 rue Cognacq Jay, Reims, France.
Journal:Acta Neurol Belg. 2022 Jun;122(3):615-623. doi: 10.1007/s13760-022-01922-3. Epub 2022 Mar 30.

20:Factors that may affect recurrence of trigeminal neuralgia after percutaneous balloon compression.
Authors:Lv W, Hu W, Chi L, Zhang L
Institution:Department of Neurosurgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China; Department of Neurosurgery, First People's Hospital of Ningyang County, Tai'an, Shandong, China.; Department of Neurosurgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, China. Electronic address:
Journal:J Clin Neurosci. 2022 May;99:248-252. doi: 10.1016/j.jocn.2022.03.022. Epub 2022 Mar 16.

21:A meta-analysis of the effectiveness and safety of microvascular decompression in elderly patients with trigeminal neuralgia.
Authors:Sun J, Wang M, Zhang L, Yu Y
Institution:National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen 518116, China.; Department of Neurosurgery, China-Japan Friendship Hospital, Chaoyang District, Beijing, China. Electronic address:
Journal:J Clin Neurosci. 2022 May;99:22-34. doi: 10.1016/j.jocn.2022.01.020. Epub 2022 Feb 25.

22:Neurologic toxicity of carbamazepine in treatment of trigeminal neuralgia.
Authors:Bridwell RE, Brown S, Clerkin S, Birdsong S, Long B
Institution:Madigan Army Medical Center, Joint Base Lewis McChord, WA 98433, United States. Electronic address:; Department of Emergency Medicine, San Antonio Uniformed Services Health Education Consortium, Fort Sam Houston, TX 78234, United States.
Journal:Am J Emerg Med. 2022 May;55:231.e3-231.e5. doi: 10.1016/j.ajem.2022.01.044. Epub 2022 Jan 21.

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