December 2022 Issue

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Spondylolisthesis abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Spondylolisthesis. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Spondylolisthesis. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Spondylolisthesis every 3 months. Thank you for your ongoing subscription to this publication.

Elliot Jacob, Ph.D.
Vice-President - Content
Medifocus.com, Inc.

1:Efficacy of transforaminal lumbar interbody fusion in the treatment of double-level lumbar spondylolisthesis with sagittal imbalance.
Authors:Luan H, Wang Y, Liu K, Sheng W, Deng Q
Institution:Department of Spine Surgery, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830054, Xinjiang, China. 1714250017@qq.com.
Journal:BMC Musculoskelet Disord. 2022 Dec 1;23(1):1038. doi: 10.1186/s12891-022-06018-w.

2:Emerging innovations for lumbar spondylolisthesis management: a systematic review of active and prospective clinical trials.
Authors:Harrison DJ, Bhandarkar AR, Durrani S, Zamanian C, Singh R, Bydon M
Institution:Mayo Clinic Neuro-Informatics Laboratory, Department of Neurologic Surgery, Mayo Clinic, 200 1St Street SW, Rochester, MN, 55905, USA. bydon.mohamad@mayo.edu.
Journal:Neurosurg Rev. 2022 Dec;45(6):3629-3640. doi: 10.1007/s10143-022-01889-y. Epub 2022 Nov 11.

3:Single-level Minimally Invasive Transforaminal Lumbar Interbody Fusion Versus Anterior Lumbar Interbody Fusion for the Surgical Treatment of Isthmic Spondylolisthesis.
Authors:Patel MR, Jacob KC, Pawlowski H, Prabhu MC, Vanjani NN, Singh K
Institution:From the Department of Orthopaedic Surgery, Rush University Medical Center, Chicago, IL.
Journal:J Am Acad Orthop Surg. 2022 Nov 1;30(21):e1382-e1390. doi: 10.5435/JAAOS-D-21-01152. Epub 2022 Sep 13.

4:Surgical outcomes between posterior decompression alone and posterior decompression with fusion surgery among patients with Meyerding grade 2 degenerative spondylolisthesis: a multicenter cohort study.
Authors:Tozawa K, Matsubayashi Y, Kato S, Doi T, Taniguchi Y, Kumanomido Y, Higashikawa A, Yosihida Y, Kawamura N, Sasaki K, Azuma S, Yu J, Hara N, Iizuka M, Ono T, Fukushima M, Takeshita Y, Tanaka S, Oshima Y
Institution:Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo, 7-3-1, Hongo, Bunkyo-Ku, 113-8655, Tokyo, Japan. yoo-tky@umin.ac.jp.
Journal:BMC Musculoskelet Disord. 2022 Oct 8;23(1):902. doi: 10.1186/s12891-022-05850-4.

5:Surgical Reduction and Direct Repair Using Pedicle Screw-Rod-Hook Fixation in Adult Patients with Low-Grade Isthmic Spondylolisthesis.
Authors:Gao Y, Zhao C, Luo L, Liu L, Liang L, Jiang D, Li P, Zhou Q
Institution:Department of Orthopedic Surgery, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Journal:Pain Res Manag. 2022 Aug 10;2022:8410519. doi: 10.1155/2022/8410519. eCollection 2022.

6:Comparing Patient-Reported Outcomes in Patients Undergoing Lumbar Fusion for Isthmic Spondylolisthesis with Predominant Back Pain versus Predominant Leg Pain Symptoms.
Authors:Jacob KC, Patel MR, Vanjani NN, Pawlowski H, Prabhu MC, Singh K
Institution:Department of Orthopaedic Surgery, Rush University Medical Center, Chicago, Illinois, USA. Electronic address: kern.singh@rushortho.com.
Journal:World Neurosurg. 2022 Oct;166:e672-e680. doi: 10.1016/j.wneu.2022.07.074. Epub 2022 Aug 4.

7:Current treatment and decision-making factors leading to fusion vs decompression for one-level degenerative spondylolisthesis: survey results from members of the Lumbar Spine Research Society and Society of Minimally Invasive Spine Surgery.
Authors:Morse KW, Steinhaus M, Bovonratwet P, Kazarian G, Gang CH, Vaishnav AS, Lafage V, Lafage R, Iyer S, Qureshi S
Institution:Department of Spine Surgery, Hospital for Special Surgery, New York, NY, USA. Electronic address: morsek@hss.edu.
Journal:Spine J. 2022 Nov;22(11):1778-1787. doi: 10.1016/j.spinee.2022.07.095. Epub 2022 Jul 23.

8:Minimally Invasive Lumbar Decompression Versus Minimally Invasive Transforaminal Lumbar Interbody Fusion for Treatment of Low-Grade Lumbar Degenerative Spondylolisthesis.
Authors:Bovonratwet P, Samuel AM, Mok JK, Vaishnav AS, Morse KW, Song J, Steinhaus ME, Jordan YJ, Gang CH, Qureshi SA
Institution:Department of Orthopaedic Surgery, Hospital for Special Surgery.
Journal:Spine (Phila Pa 1976). 2022 Nov 1;47(21):1505-1514. doi: 10.1097/BRS.0000000000004432. Epub 2022 Jul 15.

9:Outcomes Following Direct Versus Indirect Decompression Techniques for Lumbar Spondylolisthesis: A Propensity-Matched Analysis.
Authors:McKeithan LJ, Romano JW, Waddell WH, Steinle AM, Pennings JS, Nian H, Archer KR, Bydon M, Knightly J, Abtahi AM, Zuckerman SL, Stephens BF
Institution:Department of Surgery, Vanderbilt University Medical Center, Nashville, TN.; Department of Orthopaedic Surgery, Vanderbilt University Medical Center, Nashville, TN.
Journal:Spine (Phila Pa 1976). 2022 Oct 15;47(20):1443-1451. doi: 10.1097/BRS.0000000000004396. Epub 2022 Jul 15.

10:Degenerative Lumbar Spondylolisthesis Patients With Movement-related Low Back Pain Have Less Postoperative Satisfaction After Decompression Alone.
Authors:Hirota R, Teramoto A, Kimura R, Kobayashi T, Yoshimoto M, Iesato N, Okuyama K, Ogon I, Hongo M, Kasukawa Y, Tsukamoto A, Kudo D, Emori M, Iba K, Shimada Y, Miyakoshi N, Yamashita T
Institution:Department of Orthopaedic Surgery, Sapporo Medical University School of Medicine, Sapporo, Japan.
Journal:Spine (Phila Pa 1976). 2022 Oct 1;47(19):1391-1398. doi: 10.1097/BRS.0000000000004377. Epub 2022 Jul 14.

11:Sacral Pedicle Subtraction Osteotomy for Treatment of High-Grade Spondylolisthesis: A Technical Note and Review of the Literature.
Authors:Safaee MM, Scheer JK, Lau D, Fury M, Deviren V, Ames CP
Institution:Department of Neurological Surgery, University of California, San Francisco (UCSF), San Francisco, California, USA.
Journal:Oper Neurosurg (Hagerstown). 2022 Aug 1;23(2):e84-e90. doi: 10.1227/ons.0000000000000251. Epub 2022 Jun 8.

12:Long-term Radiological and Clinical Outcome after Lumbar Spinal Fusion Surgery in Patients with Degenerative Spondylolisthesis: A Prospective 6-Year Follow-up Study.
Authors:Bredow J, Meyer C, Oikonomidis S, Kernich C, Kernich N, Hofstetter CP, Heck VJ, Eysel P, Prasse T
Institution:Department of Orthopedics and Trauma Surgery, Krankenhaus Porz am Rhein, University of Cologne, Cologne, Germany.; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Orthopedics and Trauma Surgery, Cologne, Germany.
Journal:Orthop Surg. 2022 Aug;14(8):1607-1614. doi: 10.1111/os.13350. Epub 2022 Jun 16.

13:Isthmic spondylolisthesis in adults… A review of the current literature.
Authors:Alomari S, Judy B, Sacino AN, Porras JL, Tang A, Sciubba D, Witham T, Theodore N, Bydon A
Institution:Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address: abydon1@jhmi.edu.
Journal:J Clin Neurosci. 2022 Jul;101:124-130. doi: 10.1016/j.jocn.2022.04.042. Epub 2022 May 18.

14:Adult Isthmic Spondylolisthesis: A Radiographic and Outcomes Analysis Comparing Circumferential Fusions Versus TLIF Procedures.
Authors:Karamian BA, Lambrechts MJ, Mao J, D'Antonio ND, Conaway W, Canseco JA, Thandoni A, Singh A, Harlamova D, Kaye ID, Kurd M, Woods BI, Hilibrand AS, Kepler CK, Vaccaro AR, Schroeder GD
Institution:Department of Orthopaedic Surgery, Rothman Orthopaedic Institute at Thomas Jefferson University Hospital.
Journal:Clin Spine Surg. 2022 Oct 1;35(8):E660-E666. doi: 10.1097/BSD.0000000000001336. Epub 2022 Apr 7.

15:Instrumented Versus Noninstrumented Spinal Fusion for Degenerative Lumbar Spondylolisthesis: A Systematic Review.
Authors:Hirase T, Ling JF, Haghshenas V, Weiner BK
Institution:Houston Methodist Orthopedic and Sports Medicine, Houston.
Journal:Clin Spine Surg. 2022 Jun 1;35(5):213-221. doi: 10.1097/BSD.0000000000001266. Epub 2021 Oct 22.

16:Ten-Year Outcomes of Minimally Invasive Versus Open Transforaminal Lumbar Interbody Fusion in Patients With Single-Level Lumbar Spondylolisthesis.
Authors:Kwon JW, Park Y, Lee BH, Yoon SR, Ha JW, Kim H, Suk KS, Moon SH, Kim HS, Lee HM
Institution:Department of Orthopedic Surgery, Yonsei University College of Medicine, Seoul, Republic of Korea.
Journal:Spine (Phila Pa 1976). 2022 Jun 1;47(11):773-780. doi: 10.1097/BRS.0000000000004334. Epub 2022 Feb 3.

17:ALIF Versus TLIF for L5-S1 Isthmic Spondylolisthesis: ALIF Demonstrates Superior Segmental and Regional Radiographic Outcomes and Clinical Improvements Across More Patient-reported Outcome Measures Domains.
Authors:Lightsey HM 4th, Pisano AJ, Striano BM, Crawford AM, Xiong GX, Hershman S, Schoenfeld AJ, Simpson AK
Institution:Harvard Combined Orthopaedic Residency Program, Harvard Medical School, Boston, MA.; Department of Orthopaedic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, mA.
Journal:Spine (Phila Pa 1976). 2022 Jun 1;47(11):808-816. doi: 10.1097/BRS.0000000000004333. Epub 2022 Feb 3.

18:Effect of interbody fusion compared with posterolateral fusion on lumbar degenerative spondylolisthesis: a systematic review and meta-analysis.
Authors:Dantas F, Dantas FLR, Botelho RV
Institution:Department of Neurosurgery, Biocor Instituto, Nova Lima, Minas Gerais, Brazil; Faculdade de Ciencias Medicas de Minas Gerais, Feluma Post-Graduation, Belo Horizonte, Minas Gerais, Brazil; Post-Graduation in Health Sciences, IAMSPE, Sao Paulo, Sao Paulo, Brazil.; Post-Graduation in Health Sciences, IAMSPE, Sao Paulo, Sao Paulo, Brazil. Electronic address: bitbot@uol.com.br.
Journal:Spine J. 2022 May;22(5):756-768. doi: 10.1016/j.spinee.2021.12.001. Epub 2021 Dec 9.

19:Efficacy of Reverse and Modified Bohlman Technique for Lumbar Spondylolisthesis: A Systematic Review of the Literature.
Authors:Jamshidi AM, Soldozy S, Levi AD
Institution:Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA.
Journal:World Neurosurg. 2022 Jun;162:36-41. doi: 10.1016/j.wneu.2021.11.124. Epub 2021 Dec 3.

20:High-grade L5-S1 spondylolisthesis with lumbosacral kyphosis: Long-term results of non-instrumented circumferential arthrodesis in children, adolescents.
Authors:Alves A, Langlais T, Odent T, Pham AD, Pouliquen JC, Glorion C
Institution:Service d'Orthopedie et Traumatologie pediatrique, Hopital Universitaire Necker Enfants Malades, 149 rue de Sevres, 75015 Paris, France. Electronic address: alexandra.alves@aphp.fr.
Journal:Orthop Traumatol Surg Res. 2022 Oct;108(6):103093. doi: 10.1016/j.otsr.2021.103093. Epub 2021 Sep 30.

21:Does fusion status following posterolateral lumbar fusion in the treatment for stable lumbar degenerative spondylolisthesis affect the long-term surgical outcomes? A propensity score-weighted analysis of consecutive patients.
Authors:Mimura T, Tsutsumimoto T, Yui M, Misawa H
Institution:Spine Center, Yodakubo Hospital, 2857 Furumachi, Nagawa, Nagano, 386-0603, Japan.
Journal:J Orthop Sci. 2022 Sep;27(5):990-994. doi: 10.1016/j.jos.2021.07.003. Epub 2021 Aug 4.

22:Clinical outcome after lumbar spinal fusion surgery in degenerative spondylolisthesis: a 3-year follow-up.
Authors:Lenz M, Oikonomidis S, Hartwig R, Gramse R, Meyer C, Scheyerer MJ, Hofstetter C, Eysel P, Bredow J
Institution:Department of Orthopaedic and Trauma Surgery, University Hospital of Cologne, Kerpener Str. 62, 50937, Cologne, Germany. maximilian.lenz@uk-koeln.de.
Journal:Arch Orthop Trauma Surg. 2022 May;142(5):721-727. doi: 10.1007/s00402-020-03697-9. Epub 2020 Dec 29.

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